GSK3B is a serine/threonine kinase that regulates many biological processes such as muscle differentiation [], tau-microtubule interactions [], Wnt signalling []and epithelial-mesenchymal transition during embryonic development []. It has been implicated in various diseases such as diabetes, inflammation, cancer, Alzheimer's and bipolar disorder [].
A-kinase anchoring protein GSKIP is a cytosolic scaffolding protein that binds GSK3B (glycogen synthase kinase 3-beta) and PKA (protein kinase A). Both interactions with GSK3B and PKA are required for the regulation of beta-catenin, and thus Wnt signaling [].
