Ectopic expression of vesicular, over-expressed in cancer, pro-survival protein 1, VOPP1 (formerly known as EGFR-co-amplified and over- expressed protein (ECop)) increases NF-kappaB transcriptional activity []. This is achieved by promoting nuclear translocation and DNA binding of NF-kappaB. Ecop-induced NF-kappaB activation confers cellular resistance to apoptotic challenge []. It is believed that ECop is a key regulator of NF-kappaB signalling, and that high-level, amplification-mediated ECop expression, such as occurs in tumours with amplified EGFR, may contribute to resistance to apoptosis [].
