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Search results 601 to 612 out of 612 for Pfkl

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0.016s

Type

Details

Score

Publication

22923583 | -

First Author:	Yi W
Year:	2012
Journal:	Science
Title:	Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Volume:	337
Issue:	6097
Pages:	975-80

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Publication

22121020 | -

First Author:	Fujiki R
Year:	2011
Journal:	Nature
Title:	GlcNAcylation of histone H2B facilitates its monoubiquitination.
Volume:	480
Issue:	7378
Pages:	557-60

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Protein Domain

IPR037919 | OGT

Type:

Family

Description:

The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].

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Publication

15063784 | J:91808

First Author:	Kazuki Y
Year:	2004
Journal:	Biochem Biophys Res Commun
Title:	Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.
Volume:	317
Issue:	2
Pages:	491-9

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Publication

- | J:12512

First Author:	Threadgill DS
Year:	1989
Journal:	Cytogenet Cell Genet
Title:	Comparative mapping of HSA 21/MMU 16 homologs in the bovine.
Volume:	51

Pages:	1090-1091 (Abstr.)

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Publication

23353889 | J:194478

First Author:	Deplus R
Year:	2013
Journal:	EMBO J
Title:	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Volume:	32
Issue:	5
Pages:	645-55

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Publication

20200153 | -

First Author:	Mazars R
Year:	2010
Journal:	J Biol Chem
Title:	The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
Volume:	285
Issue:	18
Pages:	13364-71

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Protein

Q3TQV0

Organism:	Mus musculus/domesticus
Length:	182
Fragment?:	false

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Protein

Q80XU6

Organism:	Mus musculus/domesticus
Length:	171
Fragment?:	false

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Protein

Q8C676

Organism:	Mus musculus/domesticus
Length:	181
Fragment?:	false

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Protein

Q8CGY8

Organism:	Mus musculus/domesticus
Length:	1046
Fragment?:	false

•

Publication

20018852 | -

First Author:	Cai Y
Year:	2010
Journal:	J Biol Chem
Title:	Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Volume:	285
Issue:	7
Pages:	4268-72

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