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Search results 201 to 300 out of 300 for Baiap2

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871620
Specimen Label: UC Davis_1871620
Detected: true
Specimen Num: 40
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871621
Specimen Label: UC Davis_1871621
Detected: true
Specimen Num: 41
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871644
Specimen Label: UC Davis_1871644
Detected: true
Specimen Num: 60
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871645
Specimen Label: UC Davis_1871645
Detected: true
Specimen Num: 61
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871583
Specimen Label: UC Davis_1871583
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871622
Specimen Label: UC Davis_1871622
Detected: true
Specimen Num: 42
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•
GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5022
Specimen Label: GUDMAP:5022
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5023
Specimen Label: GUDMAP:5023
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5022
Specimen Label: GUDMAP:5022
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871595
Specimen Label: UC Davis_1871595
Detected: true
Specimen Num: 19
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871630
Specimen Label: UC Davis_1871630
Detected: true
Specimen Num: 49
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871631
Specimen Label: UC Davis_1871631
Detected: true
Specimen Num: 50
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GXD Expression
GXD Expression
Probe: MGI:4886321
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945305
Age: embryonic day 15.5
Image: g00799 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00799 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4886321
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945305
Age: postnatal day 7
Image: g00799 P7
Specimen Label: g00799 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5022
Specimen Label: GUDMAP:5022
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5023
Specimen Label: GUDMAP:5023
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:5000553
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5541113
Age: embryonic day 15.5
Image: GUDMAP:5022
Specimen Label: GUDMAP:5022
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871603
Specimen Label: UC Davis_1871603
Detected: true
Specimen Num: 25
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871647
Specimen Label: UC Davis_1871647
Detected: true
Specimen Num: 63
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871648
Specimen Label: UC Davis_1871648
Detected: true
Specimen Num: 64
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692361
Age: postnatal adult
Image: UC Davis_1871649
Specimen Label: UC Davis_1871649
Detected: true
Specimen Num: 65
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:6455448
Assay Type: RNA in situ
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2778225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6455467
Age: embryonic day 17.0
Note: Expression in tubular structures and glomeruli.
Specimen Label: S4B antisense (right)
Detected: true
Specimen Num: 2
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Publication
- | J:74917
   
First Author: Thomas EA
Year: 2001
Journal: GenBank Submission
Title: Mus musculus insulin receptor tyrosine kinase substrate protein p53 mRNA, complete cds
Pages: AF390178
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Publication
12093905 | J:77732
First Author: Rokosh DG
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.
Volume: 99
Issue: 14
Pages: 9474-9
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Publication
32116566 | J:290857
 
First Author: Kim Y
Year: 2020
Journal: Front Cell Neurosci
Title: IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes.
Volume: 14
Pages: 23
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Publication
18480067 | J:302452
First Author: Matsuda S
Year: 2008
Journal: Ann Oncol
Title: Insulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family.
Volume: 19
Issue: 7
Pages: 1356-1357
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Publication
17115031 | J:196106
First Author: Disanza A
Year: 2006
Journal: Nat Cell Biol
Title: Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.
Volume: 8
Issue: 12
Pages: 1337-47
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Publication
19083995 | J:147794
 
First Author: Sanda M
Year: 2009
Journal: Brain Res
Title: The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.
Volume: 1251
Pages: 7-15
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Publication
19933840 | J:156390
First Author: Robens JM
Year: 2010
Journal: Mol Cell Biol
Title: Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Volume: 30
Issue: 3
Pages: 829-44
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Publication
24076653 | J:202460
First Author: Disanza A
Year: 2013
Journal: EMBO J
Title: CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.
Volume: 32
Issue: 20
Pages: 2735-50
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Publication
18448434 | J:138752
First Author: Lim KB
Year: 2008
Journal: J Biol Chem
Title: The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.
Volume: 283
Issue: 29
Pages: 20454-72
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Publication
29111324 | J:251297
First Author: Lee Y
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.
Volume: 494
Issue: 3-4
Pages: 581-586
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Publication
28469556 | J:281389
 
First Author: Lee Y
Year: 2017
Journal: Front Mol Neurosci
Title: Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations.
Volume: 10
Pages: 110
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Publication
18198193 | J:131367
First Author: Abou-Kheir W
Year: 2008
Journal: J Cell Sci
Title: Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.
Volume: 121
Issue: Pt 3
Pages: 379-90
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Publication
19820184 | J:153957
First Author: Chauhan BK
Year: 2009
Journal: Development
Title: Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.
Volume: 136
Issue: 21
Pages: 3657-67
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Publication
21406566 | J:182970
First Author: Saarikangas J
Year: 2011
Journal: J Cell Sci
Title: Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Volume: 124
Issue: Pt 8
Pages: 1245-55
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Publication
19455133 | J:152628
 
First Author: Fernández E
Year: 2009
Journal: Mol Syst Biol
Title: Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.
Volume: 5
Pages: 269
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Publication
28067313 | J:275147
 
First Author: Chou AM
Year: 2017
Journal: Sci Rep
Title: Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.
Volume: 7
Pages: 40485
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Publication
21795692 | J:184110
First Author: Verpelli C
Year: 2011
Journal: J Biol Chem
Title: Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.
Volume: 286
Issue: 40
Pages: 34839-50
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Publication
19208628 | J:148808
First Author: Sawallisch C
Year: 2009
Journal: J Biol Chem
Title: The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Volume: 284
Issue: 14
Pages: 9225-36
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Publication
16870172 | J:112887
First Author: Mori AD
Year: 2006
Journal: Dev Biol
Title: Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Volume: 297
Issue: 2
Pages: 566-86
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Publication
28671696 | J:249721
First Author: Li J
Year: 2017
Journal: Nat Neurosci
Title: Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
Volume: 20
Issue: 8
Pages: 1150-1161
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Tg(Baiap2-EGFP)IS151Gsat | MGI:4846877
Name: transgene insertion IS151, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5004016 | STOCK Tg(Baiap2-EGFP)IS151Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
36520027 | J:333426
First Author: Tholen LE
Year: 2023
Journal: FASEB J
Title: HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
Volume: 37
Issue: 1
Pages: e22696
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Publication
11696321 | J:196124
First Author: Krugmann S
Year: 2001
Journal: Curr Biol
Title: Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Volume: 11
Issue: 21
Pages: 1645-55
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Publication
19913105 | -
First Author: Ahmed S
Year: 2010
Journal: Semin Cell Dev Biol
Title: I-BAR domains, IRSp53 and filopodium formation.
Volume: 21
Issue: 4
Pages: 350-6
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Publication
23740402 | -
First Author: Ferrari I
Year: 2012
Journal: Commun Integr Biol
Title: LIN7-IRSp53: A novel pathway for filopodia and neurite formation?
Volume: 5
Issue: 6
Pages: 631-3
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Publication
19286134 | -
First Author: Weiss SM
Year: 2009
Journal: Cell Host Microbe
Title: IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.
Volume: 5
Issue: 3
Pages: 244-58
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Protein Domain
IPR030128 | IRSp53
Type: Family
Description: IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Protein Domain
IPR035594 | Irsp53_SH3
Type: Domain
Description: This entry represents the SH3 domain of IRSp53. The SH3 domain of IRSp53 has been shown to bind the proline-rich C terminus of EspFu (E. coli secreted protein F-like from prophage U) [].IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Publication
21093245 | -
First Author: Zhao H
Year: 2011
Journal: Curr Opin Cell Biol
Title: I-BAR domain proteins: linking actin and plasma membrane dynamics.
Volume: 23
Issue: 1
Pages: 14-21
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Publication
21743456 | J:175296
First Author: Pykäläinen A
Year: 2011
Journal: Nat Struct Mol Biol
Title: Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
Volume: 18
Issue: 8
Pages: 902-7
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Protein
Q8BKX1
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
B1AZ46
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Q3UKP6
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3TV50
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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