|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 767 for Myh10

0.039s
Type Details Score
Publication
First Author: Guo WH
Year: 2012
Journal: Mol Biol Cell
Title: A three-component mechanism for fibroblast migration with a contractile cell body that couples a myosin II-independent propulsive anterior to a myosin II-dependent resistive tail.
Volume: 23
Issue: 9
Pages: 1657-63
Publication
First Author: Ma X
Year: 2010
Journal: Mol Biol Cell
Title: Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.
Volume: 21
Issue: 22
Pages: 3952-62
Publication
First Author: Yang F
Year: 2012
Journal: Dev Biol
Title: Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions.
Volume: 369
Issue: 2
Pages: 356-61
Publication  
First Author: Sung DC
Year: 2021
Journal: Dev Biol
Title: Mutations in non-muscle myosin 2A disrupt the actomyosin cytoskeleton in Sertoli cells and cause male infertility.
Volume: 470
Pages: 49-61
Publication
First Author: Badirou I
Year: 2014
Journal: Blood
Title: Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization.
Volume: 124
Issue: 16
Pages: 2564-8
Publication
First Author: Milberg O
Year: 2017
Journal: J Cell Biol
Title: Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals.
Volume: 216
Issue: 7
Pages: 1925-1936
Publication
First Author: Ma X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
Volume: 109
Issue: 12
Pages: 4509-14
Publication
First Author: Patzak A
Year: 2005
Journal: Kidney Int
Title: Constriction velocities of renal afferent and efferent arterioles of mice are not related to SMB expression.
Volume: 68
Issue: 6
Pages: 2726-34
Publication
First Author: Getty AL
Year: 2011
Journal: Exp Cell Res
Title: A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3(-/-) cells.
Volume: 317
Issue: 1
Pages: 51-69
Publication
First Author: Tullio AN
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Nonmuscle myosin II-B is required for normal development of the mouse heart.
Volume: 94
Issue: 23
Pages: 12407-12
Publication
First Author: Turney SG
Year: 2005
Journal: Nat Neurosci
Title: Laminin stimulates and guides axonal outgrowth via growth cone myosin II activity.
Volume: 8
Issue: 6
Pages: 717-9
Publication
First Author: Takeda K
Year: 2003
Journal: Circ Res
Title: Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis.
Volume: 93
Issue: 4
Pages: 330-7
Publication
First Author: Uren D
Year: 2000
Journal: J Clin Invest
Title: Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice.
Volume: 105
Issue: 5
Pages: 663-71
Publication
First Author: Wang H
Year: 2012
Journal: J Neurosci Res
Title: Myosin II is a negative regulator of oligodendrocyte morphological differentiation.
Volume: 90
Issue: 8
Pages: 1547-56
Publication
First Author: Garita B
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart looping.
Volume: 300
Issue: 3
Pages: H879-91
Publication
First Author: Simerly C
Year: 1998
Journal: Mol Biol Cell
Title: Differential expression and functions of cortical myosin IIA and IIB isotypes during meiotic maturation, fertilization, and mitosis in mouse oocytes and embryos.
Volume: 9
Issue: 9
Pages: 2509-25
Publication
First Author: Kim KY
Year: 2005
Journal: J Biol Chem
Title: Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
Volume: 280
Issue: 24
Pages: 22769-75
Publication
First Author: Eddinger TJ
Year: 1993
Journal: Cell Motil Cytoskeleton
Title: Expression of four myosin heavy chain isoforms with development in mouse uterus.
Volume: 25
Issue: 4
Pages: 358-68
Publication
First Author: Mieziewska K
Year: 1994
Journal: J Comp Neurol
Title: Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina.
Volume: 345
Issue: 1
Pages: 115-24
Publication
First Author: Beach JR
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition.
Volume: 108
Issue: 44
Pages: 17991-6
Publication
First Author: Yu P
Year: 2012
Journal: J Neurochem
Title: Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans.
Volume: 120
Issue: 6
Pages: 1117-28
Publication
First Author: Doyle AD
Year: 2012
Journal: J Cell Sci
Title: Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics.
Volume: 125
Issue: Pt 9
Pages: 2244-56
Publication
First Author: Liu X
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II.
Volume: 110
Issue: 29
Pages: 11976-81
Publication
First Author: White J
Year: 2014
Journal: Anat Rec (Hoboken)
Title: Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes.
Volume: 297
Issue: 9
Pages: 1571-84
Publication
First Author: Halder D
Year: 2019
Journal: Mol Biol Cell
Title: Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.
Volume: 30
Issue: 12
Pages: 1463-1476
Publication
First Author: Xu X
Year: 2011
Journal: Curr Biol
Title: A secreted protein promotes cleavage furrow maturation during cytokinesis.
Volume: 21
Issue: 2
Pages: 114-9
Publication  
First Author: Ronzier E
Year: 2022
Journal: Cells
Title: The Actin Cytoskeleton Responds to Inflammatory Cues and Alters Macrophage Activation.
Volume: 11
Issue: 11
Publication    
First Author: Hammers DW
Year: 2021
Journal: Elife
Title: Filopodia powered by class x myosin promote fusion of mammalian myoblasts.
Volume: 10
Publication
First Author: Hitachi K
Year: 2023
Journal: FASEB J
Title: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
Volume: 37
Issue: 1
Pages: e22692
Publication
First Author: Yagi H
Year: 2017
Journal: PLoS One
Title: Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
Volume: 12
Issue: 2
Pages: e0172257
Publication
First Author: Williams M
Year: 2014
Journal: Dev Cell
Title: Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate.
Volume: 29
Issue: 1
Pages: 34-46
Publication
First Author: Ma X
Year: 2006
Journal: Mol Biol Cell
Title: Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development.
Volume: 17
Issue: 5
Pages: 2138-49
Publication
First Author: Huang H
Year: 2003
Journal: Mol Cell Biol
Title: Nonmuscle myosin promotes cytoplasmic localization of PBX.
Volume: 23
Issue: 10
Pages: 3636-45
Publication
First Author: Argellati F
Year: 2009
Journal: FASEB J
Title: Protein kinase C-dependent alpha-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B.
Volume: 23
Issue: 4
Pages: 1246-51
Publication
First Author: Ju XD
Year: 2014
Journal: Cereb Cortex
Title: Both Myosin-10 isoforms are required for radial neuronal migration in the developing cerebral cortex.
Volume: 24
Issue: 5
Pages: 1259-68
Publication
First Author: Zhu XJ
Year: 2007
Journal: Nat Cell Biol
Title: Myosin X regulates netrin receptors and functions in axonal path-finding.
Volume: 9
Issue: 2
Pages: 184-92
Publication
First Author: Vogt EJ
Year: 2019
Journal: Nat Commun
Title: Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.
Volume: 10
Issue: 1
Pages: 2271
Publication
First Author: Golomb E
Year: 2004
Journal: J Biol Chem
Title: Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family.
Volume: 279
Issue: 4
Pages: 2800-8
Publication
First Author: Kim KK
Year: 2011
Journal: Nucleic Acids Res
Title: Fox-3 and PSF interact to activate neural cell-specific alternative splicing.
Volume: 39
Issue: 8
Pages: 3064-78
Publication
First Author: Woroniuk A
Year: 2018
Journal: Nat Commun
Title: STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Volume: 9
Issue: 1
Pages: 2124
Publication
First Author: Maître JL
Year: 2016
Journal: Nature
Title: Asymmetric division of contractile domains couples cell positioning and fate specification.
Volume: 536
Issue: 7616
Pages: 344-348
Publication
First Author: Ma X
Year: 2020
Journal: Mol Biol Cell
Title: Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis.
Volume: 31
Issue: 18
Pages: 1974-1987
Publication
First Author: Picariello HS
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.
Volume: 116
Issue: 31
Pages: 15550-15559
Publication
First Author: Wang XW
Year: 2020
Journal: Cell Rep
Title: Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration.
Volume: 31
Issue: 3
Pages: 107537
Publication
First Author: Harunaga JS
Year: 2014
Journal: Dev Biol
Title: Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility.
Volume: 394
Issue: 2
Pages: 197-205
Publication
First Author: Wang F
Year: 2018
Journal: J Cell Biol
Title: Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.
Volume: 217
Issue: 12
Pages: 4314-4330
Publication
First Author: Sulistomo HW
Year: 2019
Journal: J Biol Chem
Title: Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction.
Volume: 294
Issue: 8
Pages: 2924-2934
Publication
First Author: Tsuda T
Year: 1998
Journal: Dev Genet
Title: Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stages.
Volume: 23
Issue: 3
Pages: 203-14
Publication
First Author: Lu W
Year: 2008
Journal: Dev Dyn
Title: Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.
Volume: 237
Issue: 12
Pages: 3577-90
Publication
First Author: Houssin NS
Year: 2020
Journal: Dev Biol
Title: Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination.
Volume: 462
Issue: 1
Pages: 36-49
Publication
First Author: Vega-Riveroll LJ
Year: 2005
Journal: Neuroreport
Title: Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals.
Volume: 16
Issue: 11
Pages: 1143-6
Publication
First Author: Swailes NT
Year: 2006
Journal: J Cell Sci
Title: Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse.
Volume: 119
Issue: Pt 17
Pages: 3561-70
Publication
First Author: Murakami N
Year: 1993
Journal: Dev Biol
Title: Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.
Volume: 157
Issue: 1
Pages: 19-27
Publication
First Author: Marigo V
Year: 2004
Journal: Genomics
Title: Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.
Volume: 83
Issue: 6
Pages: 1125-33
Publication
First Author: Maddala R
Year: 2007
Journal: Differentiation
Title: Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse.
Volume: 75
Issue: 8
Pages: 713-25
Publication
First Author: Hirota Y
Year: 2010
Journal: Development
Title: Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.
Volume: 137
Issue: 18
Pages: 3037-46
Publication
First Author: Yen WW
Year: 2009
Journal: Development
Title: PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.
Volume: 136
Issue: 12
Pages: 2039-48
Publication
First Author: Hildebrand JD
Year: 2005
Journal: J Cell Sci
Title: Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.
Volume: 118
Issue: Pt 22
Pages: 5191-203
Publication  
First Author: Sun J
Year: 2020
Journal: Front Physiol
Title: Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction.
Volume: 11
Pages: 593966
Publication
First Author: Escuin S
Year: 2015
Journal: J Cell Sci
Title: Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.
Volume: 128
Issue: 14
Pages: 2468-81
Publication
First Author: Chauhan BK
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.
Volume: 108
Issue: 45
Pages: 18289-94
Publication
First Author: Sáez de Guinoa J
Year: 2011
Journal: Blood
Title: CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.
Volume: 118
Issue: 6
Pages: 1560-9
Publication  
First Author: Figueiredo AM
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Endothelial cell invasion is controlled by dactylopodia.
Volume: 118
Issue: 18
Publication
First Author: Marcos S
Year: 2009
Journal: PLoS One
Title: Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone.
Volume: 4
Issue: 4
Pages: e5405
Publication
First Author: Zhang Y
Year: 2018
Journal: Mol Biol Cell
Title: Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice.
Volume: 29
Issue: 19
Pages: 2326-2335
Publication
First Author: Conti MA
Year: 2004
Journal: J Biol Chem
Title: Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice.
Volume: 279
Issue: 40
Pages: 41263-6
Publication
First Author: Yamamoto N
Year: 2009
Journal: Development
Title: Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
Volume: 136
Issue: 12
Pages: 1977-86
Publication
First Author: Hemkemeyer SA
Year: 2022
Journal: Dev Dyn
Title: The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis.
Volume: 251
Issue: 11
Pages: 1897-1907
Publication
First Author: Plageman TF Jr
Year: 2011
Journal: Dev Biol
Title: Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.
Volume: 357
Issue: 1
Pages: 227-34
Publication
First Author: Luccardini C
Year: 2013
Journal: J Neurosci
Title: N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration.
Volume: 33
Issue: 46
Pages: 18149-60
Publication  
First Author: Yagi H
Year: 2014
Journal: Sci Rep
Title: Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation.
Volume: 4
Pages: 6353
Publication
First Author: Ma X
Year: 2004
Journal: Mol Biol Cell
Title: A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons.
Volume: 15
Issue: 6
Pages: 2568-79
Publication
First Author: Goering JP
Year: 2021
Journal: Hum Mol Genet
Title: In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.
Volume: 31
Issue: 1
Pages: 18-31
Publication
First Author: Tullio AN
Year: 2001
Journal: J Comp Neurol
Title: Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain.
Volume: 433
Issue: 1
Pages: 62-74
Publication
First Author: Harb N
Year: 2008
Journal: PLoS One
Title: The Rho-Rock-Myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells.
Volume: 3
Issue: 8
Pages: e3001
Publication
First Author: Plosa EJ
Year: 2012
Journal: Dev Dyn
Title: Nonmuscle myosin II regulation of lung epithelial morphology.
Volume: 241
Issue: 11
Pages: 1770-81
Publication
First Author: Sumigray K
Year: 2014
Journal: PLoS One
Title: Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
Volume: 9
Issue: 7
Pages: e101824
Publication
First Author: Lang RA
Year: 2014
Journal: Development
Title: p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.
Volume: 141
Issue: 16
Pages: 3177-87
Publication
First Author: Muccioli M
Year: 2016
Journal: Dev Biol
Title: Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition.
Volume: 412
Issue: 1
Pages: 32-43
Publication
First Author: Argent L
Year: 2020
Journal: J Biol Chem
Title: Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Volume: 295
Issue: 36
Pages: 12716-12726
Publication
First Author: McGreevy EM
Year: 2015
Journal: Biol Open
Title: Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.
Volume: 4
Issue: 2
Pages: 186-96
Publication
First Author: Kim S
Year: 2015
Journal: PLoS Biol
Title: Convergence and extrusion are required for normal fusion of the mammalian secondary palate.
Volume: 13
Issue: 4
Pages: e1002122
Publication
First Author: Campos Y
Year: 2010
Journal: PLoS One
Title: Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.
Volume: 5
Issue: 3
Pages: e9866
Publication
First Author: Strilić B
Year: 2009
Journal: Dev Cell
Title: The molecular basis of vascular lumen formation in the developing mouse aorta.
Volume: 17
Issue: 4
Pages: 505-15
Publication
First Author: Ma X
Year: 2007
Journal: Mol Biol Cell
Title: Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice.
Volume: 18
Issue: 6
Pages: 2305-12
Publication
First Author: Amparan D
Year: 2005
Journal: J Neurochem
Title: Direct interaction of myosin regulatory light chain with the NMDA receptor.
Volume: 92
Issue: 2
Pages: 349-61
Publication
First Author: El-Hashash AH
Year: 2011
Journal: Dev Dyn
Title: Cell polarity and spindle orientation in the distal epithelium of embryonic lung.
Volume: 240
Issue: 2
Pages: 441-5
Publication
First Author: Yu J
Year: 2011
Journal: Hum Mol Genet
Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Volume: 20
Issue: 6
Pages: 1061-73
Publication
First Author: Chen HH
Year: 2015
Journal: J Cell Sci
Title: NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration.
Volume: 128
Issue: 22
Pages: 4196-209
Publication  
First Author: Wilson NR
Year: 2016
Journal: Sci Rep
Title: SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
Volume: 6
Pages: 17735
Publication
First Author: Alfano D
Year: 2019
Journal: Hum Mol Genet
Title: Tbx1 regulates extracellular matrix-cell interactions in the second heart field.
Volume: 28
Issue: 14
Pages: 2295-2308
Publication
First Author: Chauhan BK
Year: 2009
Journal: Development
Title: Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.
Volume: 136
Issue: 21
Pages: 3657-67
Publication  
First Author: Teng T
Year: 2022
Journal: Development
Title: A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis.
Volume: 149
Issue: 10
Publication
First Author: Tenin G
Year: 2014
Journal: PLoS One
Title: Erbb2 is required for cardiac atrial electrical activity during development.
Volume: 9
Issue: 9
Pages: e107041
Publication
First Author: Uchiyama Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
Volume: 107
Issue: 20
Pages: 9240-5
Publication
First Author: Klezovitch O
Year: 2004
Journal: Genes Dev
Title: Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.
Volume: 18
Issue: 5
Pages: 559-71
Publication
First Author: Logan CM
Year: 2017
Journal: Dev Biol
Title: N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis.
Volume: 428
Issue: 1
Pages: 118-134
Publication  
First Author: Brown JM
Year: 2018
Journal: Development
Title: Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.
Volume: 145
Issue: 19
Publication  
First Author: Lesko AC
Year: 2021
Journal: Dev Biol
Title: Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.
Volume: 478
Pages: 59-75
Publication
First Author: Lee J
Year: 2012
Journal: Curr Biol
Title: PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.
Volume: 22
Issue: 11
Pages: 956-66