|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 374 for Jak3

<< First    < Previous  |  Next >    Last >>
0.036s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
26744474 | J:233908
First Author: Magalhães D
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Role of epithelial ion transports in inflammatory bowel disease.
Volume: 310
Issue: 7
Pages: G460-76
•
•
•
•
•
Publication
32699230 | J:294041
First Author: Sakano D
Year: 2020
Journal: Sci Rep
Title: Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance.
Volume: 10
Issue: 1
Pages: 12187
•
•
•
•
•
Publication
17015722 | J:139439
First Author: Regunathan J
Year: 2006
Journal: J Immunol
Title: Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.
Volume: 177
Issue: 8
Pages: 5365-76
•
•
•
•
•
Publication
16354682 | J:104166
First Author: Dai X
Year: 2006
Journal: Mol Cell Biol
Title: Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
Volume: 26
Issue: 1
Pages: 88-99
•
•
•
•
•
Publication
10526570 | J:58302
First Author: Yeh TC
Year: 1999
Journal: Cell Mol Life Sci
Title: The Janus kinase family of protein tyrosine kinases and their role in signaling.
Volume: 55
Issue: 12
Pages: 1523-34
•
•
•
•
•
Publication
22972935 | J:187745
First Author: Doles J
Year: 2012
Journal: Genes Dev
Title: Age-associated inflammation inhibits epidermal stem cell function.
Volume: 26
Issue: 19
Pages: 2144-53
•
•
•
•
•
Publication
27077371 | J:249310
First Author: Goldstein JD
Year: 2016
Journal: PLoS One
Title: Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
Volume: 11
Issue: 4
Pages: e0153682
•
•
•
•
•
Publication
9889194 | J:52380
First Author: Nicholson SE
Year: 1999
Journal: EMBO J
Title: Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
Volume: 18
Issue: 2
Pages: 375-85
•
•
•
•
•
Publication
10490101 | J:57476
First Author: Marine JC
Year: 1999
Journal: Cell
Title: SOCS3 is essential in the regulation of fetal liver erythropoiesis.
Volume: 98
Issue: 5
Pages: 617-27
•
•
•
•
•
Publication
18852293 | J:141103
First Author: Junttila IS
Year: 2008
Journal: J Exp Med
Title: Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.
Volume: 205
Issue: 11
Pages: 2595-608
•
•
•
•
•
Publication
16418296 | J:105655
First Author: Yao Z
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Stat5a/b are essential for normal lymphoid development and differentiation.
Volume: 103
Issue: 4
Pages: 1000-5
•
•
•
•
•
Publication
9858510 | J:51703
First Author: Durum SK
Year: 1998
Journal: J Exp Med
Title: Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.
Volume: 188
Issue: 12
Pages: 2233-41
•
•
•
•
•
Publication
24166977 | J:207012
First Author: Cho JH
Year: 2013
Journal: J Immunol
Title: Unique features of naive CD8+ T cell activation by IL-2.
Volume: 191
Issue: 11
Pages: 5559-73
•
•
•
•
•
Publication
28191885 | J:251092
First Author: Chuang CH
Year: 2017
Journal: Nat Med
Title: Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.
Volume: 23
Issue: 3
Pages: 291-300
•
•
•
•
•
Publication
10485657 | J:98326
First Author: Moriggl R
Year: 1999
Journal: Immunity
Title: Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells.
Volume: 11
Issue: 2
Pages: 225-30
•
•
•
•
•
Publication
8593242 | J:33063
First Author: Finbloom DS
Year: 1995
Journal: Cell Signal
Title: Regulation of the Jak/STAT signalling pathway.
Volume: 7
Issue: 8
Pages: 739-45
•
•
•
•
•
Publication
8918879 | J:36745
First Author: Liu ZG
Year: 1996
Journal: Nature
Title: Three distinct signalling responses by murine fibroblasts to genotoxic stress.
Volume: 384
Issue: 6606
Pages: 273-6
•
•
•
•
•
Publication
19361784 | J:149493
First Author: Hirata N
Year: 2009
Journal: Cell Immunol
Title: Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.
Volume: 258
Issue: 1
Pages: 9-17
•
•
•
•
•
Publication
15917267 | J:99793
First Author: Mazón Peláez I
Year: 2005
Journal: Hum Mol Genet
Title: Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
Volume: 14
Issue: 14
Pages: 1977-89
•
•
•
•
•
Publication
23435120 | J:194747
First Author: Bell BD
Year: 2013
Journal: Nat Immunol
Title: The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
Volume: 14
Issue: 4
Pages: 364-71
•
•
•
•
•
Publication
10490100 | J:57475
First Author: Marine JC
Year: 1999
Journal: Cell
Title: SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
Volume: 98
Issue: 5
Pages: 609-16
•
•
•
•
•
Publication
9342212 | J:43723
First Author: Pellegrini S
Year: 1997
Journal: Eur J Biochem
Title: The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).
Volume: 248
Issue: 3
Pages: 615-33
•
•
•
•
•
Publication
9638363 | J:48063
First Author: Liu KD
Year: 1998
Journal: Curr Opin Immunol
Title: JAK/STAT signaling by cytokine receptors.
Volume: 10
Issue: 3
Pages: 271-8
•
•
•
•
•
Publication
10872802 | J:62510
First Author: Iseki M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Volume: 272
Issue: 1
Pages: 45-54
•
•
•
•
•
Publication
26384545 | J:233785
First Author: Dupaul-Chicoine J
Year: 2015
Journal: Immunity
Title: The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.
Volume: 43
Issue: 4
Pages: 751-63
•
•
•
•
•
Publication
23603794 | J:197353
First Author: Roediger B
Year: 2013
Journal: Nat Immunol
Title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Volume: 14
Issue: 6
Pages: 564-73
•
•
•
•
•
Publication
26404745 | J:233778
First Author: Chopra M
Year: 2015
Journal: Eur J Immunol
Title: Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development.
Volume: 45
Issue: 12
Pages: 3362-74
•
•
•
•
•
Publication
25605905 | J:217665
First Author: Wang T
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Real-time resolution of point mutations that cause phenovariance in mice.
Volume: 112
Issue: 5
Pages: E440-9
•
•
•
•
•
Publication
22284677 | J:232386
First Author: Van Nguyen T
Year: 2012
Journal: Mol Cell
Title: SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.
Volume: 45
Issue: 2
Pages: 210-21
•
•
•
•
•
Publication
10687308 | J:60454
First Author: Matsumoto M
Year: 1999
Journal: J Med Invest
Title: Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
Volume: 46
Issue: 3-4
Pages: 141-50
•
•
•
•
•
Publication
10781830 | J:62318
First Author: Imada K
Year: 2000
Journal: Mol Immunol
Title: The Jak-STAT pathway.
Volume: 37
Issue: 1-2
Pages: 1-11
•
•
•
•
•
Publication
10200816 | J:53840
First Author: Brown MP
Year: 1999
Journal: Aust N Z J Med
Title: Cytokines, Jaks, Stats, health and disease.
Volume: 29
Issue: 1
Pages: 73-8
•
•
•
•
•
Publication
11437454 | J:70363
First Author: Brunskill EW
Year: 2001
Journal: Dev Biol
Title: Novel cell lines promote the discovery of genes involved in early heart development.
Volume: 235
Issue: 2
Pages: 507-20
•
•
•
•
•
Publication
10931824 | J:65478
First Author: Koza RA
Year: 2000
Journal: J Biol Chem
Title: Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue.
Volume: 275
Issue: 44
Pages: 34486-92
•
•
•
•
•
Publication
34360789 | J:310414
 
First Author: Hung CH
Year: 2021
Journal: Int J Mol Sci
Title: A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
Volume: 22
Issue: 15
•
•
•
•
•
Publication
15245428 | J:91218
First Author: Sundberg JP
Year: 2004
Journal: J Invest Dermatol
Title: Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model.
Volume: 123
Issue: 2
Pages: 294-7
•
•
•
•
•
Publication
35493520 | J:324243
 
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
•
•
•
•
•
Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
•
•
•
•
•
Publication
24859004 | J:219394
First Author: Boroviak T
Year: 2014
Journal: Nat Cell Biol
Title: The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Volume: 16
Issue: 6
Pages: 516-28
•
•
•
•
•
Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 1
Description: Tyrosine-protein kinase JAK3
Type: chain
End: 1100
•
•
•
•
•
Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
•
•
•
•
•
Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
•
•
•
•
•
Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Protein
Q62137
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
•
•
•
•
•
Publication
16843266 | J:110966
First Author: Walters DK
Year: 2006
Journal: Cancer Cell
Title: Activating alleles of JAK3 in acute megakaryoblastic leukemia.
Volume: 10
Issue: 1
Pages: 65-75
•
•
•
•
•
Protein Domain
IPR020775 | Tyr_kinase_non-rcpt_Jak3
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].Janus kinases (JAKs) are tyrosine kinases that function in membrane-proximal signalling events initiated by a variety of extracellular factors binding to cell surface receptors []. Many type I and II cytokine receptors lack a protein tyrosine kinase domain and rely on JAKs to initiate the cytoplasmic signal transduction cascade. Ligand binding induces oligomerisation of the receptors, which then activates the cytoplasmic receptor-associated JAKs. These subsequently phosphorylate tyrosine residues along the receptor chains with which they are associated. The phosphotyrosine residues are a target for a variety of SH2 domain-containing transducer proteins. Amongst these are the signal transducers and activators of transcription (STAT) proteins, which, after binding to the receptor chains, are phosphorylated by the JAK proteins. Phosphorylation enables the STAT proteins to dimerise and translocate into the nucleus, where they alter the expression of cytokine-regulated genes. This system is known as the JAK-STAT pathway.Four mammalian JAK family members have been identified: JAK1, JAK2, JAK3, and TYK2. They are relatively large kinases of approximately 1150 amino acids, with molecular weights of ~120-130kDa. Their amino acid sequences are characterised by the presence of 7 highly conserved domains, termed JAK homology (JH) domains. The C-terminal domain (JH1) is responsible for the tyrosine kinase function. The next domain in the sequence (JH2) is known as the tyrosine kinase-like domain, as its sequence shows high similarity to functional kinases but does not possess any catalytic activity. Although the function of this domain is not well established, there is some evidence for a regulatory role on the JH1 domain, thus modulating catalytic activity. The N-terminal portion of the JAKs (spanning JH7 to JH3) is important for receptor association and non-catalytic activity, and consists of JH3-JH4, which is homologous to the SH2 domain, and lastly JH5-JH7, which is a FERM domain.This represents the non-receptor tyrosine kinase JAK3, which is involved in the interleukin-2 and interleukin-4 signalling pathway. Jak3 phosphorylates STAT6, IRS1, IRS2 and PI3K [].
•
•
•
•
•
Publication
29187379 | J:262168
First Author: Degryse S
Year: 2018
Journal: Blood
Title: Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.
Volume: 131
Issue: 4
Pages: 421-425
•
•
•
•
•
Allele
Jak3<tm1Jni> | MGI:2675061
Name: Janus kinase 3; targeted mutation 1, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Protein
Q62137-2
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
•
•
•
•
•
Publication
35459909 | J:330712
First Author: Das Gupta D
Year: 2022
Journal: Cell Death Differ
Title: IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Volume: 29
Issue: 11
Pages: 2163-2176
•
•
•
•
•
Publication
10733938 | -
First Author: Ji H
Year: 2000
Journal: Biochem Biophys Res Commun
Title: A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival.
Volume: 270
Issue: 1
Pages: 267-71
•
•
•
•
•
Publication
21821710 | J:178412
First Author: Elliott NE
Year: 2011
Journal: Blood
Title: FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.
Volume: 118
Issue: 14
Pages: 3911-21
•
•
•
•
•
Publication
21106989 | J:169577
First Author: Ju W
Year: 2011
Journal: Blood
Title: CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Volume: 117
Issue: 6
Pages: 1938-46
•
•
•
•
•
Interaction Experiment
Wu W (2011)
Description: A mechanism underlying notch-induced and ubiquitin-mediated Jak3 degradation.
•
•
•
•
•
Allele
Jak3<em1Smoc> | MGI:7290629
Name: Janus kinase 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
21969365 | -
First Author: Wu W
Year: 2011
Journal: J Biol Chem
Title: A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.
Volume: 286
Issue: 48
Pages: 41153-62
•
•
•
•
•
Publication
19290934 | -
First Author: Ghoreschi K
Year: 2009
Journal: Immunol Rev
Title: Janus kinases in immune cell signaling.
Volume: 228
Issue: 1
Pages: 273-87
•
•
•
•
•
Allele
Tg(Lck-Jak3)2Ljb | MGI:3769343
Name: transgene insertion 2, Leslie J Berg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Jak3<X887Y> | MGI:3665252
 
Name: Janus kinase 3; X887Y
Allele Type: Spontaneous
•
•
•
•
•
Allele
Jak3<em1Jsca> | MGI:6719599
 
Name: Janus kinase 3; endonuclease-mediated mutation 1, J Simon C Arthur
Allele Type: Endonuclease-mediated
•
•
•
•
•
Allele
Tg(Lck-Jak3)1Ljb | MGI:3769344
Name: transgene insertion 1, Leslie J Berg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Protein
Q9JMH9
Organism: Mus musculus/domesticus
Length: 2050  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-2
Organism: Mus musculus/domesticus
Length: 1719  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-5
Organism: Mus musculus/domesticus
Length: 1704  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-1
Organism: Mus musculus/domesticus
Length: 2035  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-4
Organism: Mus musculus/domesticus
Length: 1998  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-7
Organism: Mus musculus/domesticus
Length: 1716  
Fragment?: false
•
•
•
•
•
Protein
Q9JMH9-6
Organism: Mus musculus/domesticus
Length: 2062  
Fragment?: false
•
•
•
•
•
DO Term
DOID:0060008 | janus kinase-3 deficiency
•
•
•
•
•
Genotype
Genotype
Symbol: Jak3/Jak3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom