Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
28
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
100
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
416
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
629
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chaya T |
Year: |
2014 |
Journal: |
EMBO J |
Title: |
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. |
Volume: |
33 |
Issue: |
11 |
Pages: |
1227-42 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
629
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
503
|
Fragment?: |
true |
|
•
•
•
•
•
|
Ontology Term |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Serine/threonine-protein kinase ICK |
Type: |
chain |
End: |
629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Broekhuis JR |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e108470 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oud MM |
Year: |
2016 |
Journal: |
Cilia |
Title: |
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome. |
Volume: |
5 |
|
Pages: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moon H |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling. |
Volume: |
111 |
Issue: |
23 |
Pages: |
8541-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bailey JN |
Year: |
2018 |
Journal: |
N Engl J Med |
Title: |
Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy. |
Volume: |
378 |
Issue: |
11 |
Pages: |
1018-1028 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okamoto S |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function. |
Volume: |
37 |
Issue: |
8 |
Pages: |
2073-2085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Togawa K |
Year: |
2000 |
Journal: |
J Cell Physiol |
Title: |
Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. |
Volume: |
183 |
Issue: |
1 |
Pages: |
129-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu Z |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. |
Volume: |
25 |
Issue: |
14 |
Pages: |
6047-64 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Korolkova Y |
Year: |
2021 |
Journal: |
Toxins (Basel) |
Title: |
New Insectotoxin from Tibellus Oblongus Spider Venom Presents Novel Adaptation of ICK Fold. |
Volume: |
13 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang S |
Year: |
2004 |
Journal: |
Toxicon |
Title: |
An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]. |
Volume: |
43 |
Issue: |
5 |
Pages: |
575-85 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry consists of the huwentoxin-II (HWTX-II) family of toxins secreted by spiders. These toxins are found in venom that secreted from the bird spider Selenocosmia huwena Wang. The HWTX-II adopts a novel scaffold different from the ICK motif that is found in other huwentoxins. HWTX-II consists of 37 amino acids residues including six cysteines involved in three disulphide bridges []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Villegas E |
Year: |
2008 |
Journal: |
Toxicon |
Title: |
Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels. |
Volume: |
52 |
Issue: |
2 |
Pages: |
228-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nadezhdin KD |
Year: |
2017 |
Journal: |
Protein Sci |
Title: |
Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane-mimicking environment. |
Volume: |
26 |
Issue: |
3 |
Pages: |
611-616 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sachkova MY |
Year: |
2014 |
Journal: |
FEBS Lett |
Title: |
Genes and evolution of two-domain toxins from lynx spider venom. |
Volume: |
588 |
Issue: |
5 |
Pages: |
740-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vassilevski AA |
Year: |
2013 |
Journal: |
FEBS J |
Title: |
Spider toxins comprising disulfide-rich and linear amphipathic domains: a new class of molecules identified in the lynx spider Oxyopes takobius. |
Volume: |
280 |
Issue: |
23 |
Pages: |
6247-61 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Spiders are widely acknowledged to produce potent and selective toxins. In addition to the conventional neurotoxins and cytotoxins, venom of lynx spiders (genus Oxyopes) was found to contain two-domain modular toxins named spiderines: OspTx1a, 1b, 2a and 2b [, , ]. Spiderines consist of two distinct modules separated by a short linker. The N-terminal part (~40 residues) contains no cysteine residues, is highly cationic, forms amphipathic alpha- helical structures in a membrane-mimicking environment, and shows potent cytolytic effects on cells of various origins. The short linker resembles closely the processing quadruplet motif (PQM), which is known to indicate the processing cleavage site in precursors of spider toxins and separate the prosequence from the mature chain. The C-terminal part (~60 residues) is a disulfide rich domain reticulated by five S-S bridges that is homologous to one-domain oxytoxins (OxyTx1 and OxyTx2) from Oxypes species. Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) []. The core of the oxytoxin-like domain is the inhibitor cystine knot (ICK) or knottin motif. The domain is stabilised by five disulfides and 13 hydrogen bonds. Two antiparallel β-strands form a short β-sheet, and there are two β-turns in the N-terminal part of of the domain. C1-C5, C2-C6, and C4-C9 disulfides contribute to the ICK motif, whereas C7-C8 stabilises the extended loop of the β-hairpin and C3-C10 staples the lengthy C-terminal of the domain to its core [].This entry represents the oxytoxin-type ICK domain. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong Y |
Year: |
2017 |
Journal: |
FEBS Lett |
Title: |
An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome. |
Volume: |
591 |
Issue: |
9 |
Pages: |
1247-1257 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paige Taylor S |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome. |
Volume: |
25 |
Issue: |
18 |
Pages: |
3998-4011 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kunova Bosakova M |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bende NS |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. |
Volume: |
5 |
|
Pages: |
4350 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family members are 56-59 residue mu-diguetoxin-1 and beta-diguetoxin-1 toxins, which have been isolated from the weaving spider, Diguetia canities. These toxins were isolated as a result of their potent insect paralytic activities, and designated beta-DGTX-Dc1a, mu-DGTX-Dc1b and mu-DGTX-Dc1c (formerly DTX9.2, DTX11 and DTX12) []. Diguetoxin-Dc1a (Dc1a) has been structurally characterised and shown to have disulfide bonds which form a classical inhibitor cysteine knot (ICK) motif in which the Cys13-Cys26 and Cys20-Cys40 disulfide bonds and the intervening sections of the polypeptide backbone form a 23-residue ring that is pierced by the Cys25-Cys54 disulfide bond. This ICK motif is commonly found in spider toxins, and this particular scaffold provides these peptides (so-called knottins) with an unusually high degree of chemical, thermal and biological stability. Dc1a contains an additional disulfide bond (Cys42-Cys52) that appears to serve as a molecular staple which limits the flexibility of a disordered serine-rich hairpin loop. The extended N terminus of Dc1a along with an unusually large loop between Cys26 and Cys40 enables the formation of an N-terminal three-stranded antiparallel β-sheet that is not found in any other knottin. The molecular surface of Dc1a contains a relatively uniform distribution of charged residues; moreover, there are no distinct clusters of hydrophobic residues that might mediate an interaction with lipid bilayers []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding M |
Year: |
2018 |
Journal: |
Calcif Tissue Int |
Title: |
A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development. |
Volume: |
102 |
Issue: |
3 |
Pages: |
348-357 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bolick DT |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e106902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Windley MJ |
Year: |
2012 |
Journal: |
Toxins (Basel) |
Title: |
Spider-venom peptides as bioinsecticides. |
Volume: |
4 |
Issue: |
3 |
Pages: |
191-227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|