Homer (also known as Vesl) family members, including Homer1/2/3, are synaptic scaffolding proteins that regulate localisation of group 1 metabotropic glutamate receptors (mGluRs), which are known to play major roles in neural signal transduction. Homer family members contain the EVH1 domain at the N terminus for receptor binding, two leucine zipper motifs at the C terminus for clustering, and a linking region whose function is unclear. Besides binding to mGluR, Homer family members also recognise the PPXXF motif found in other binding partners []. Homer2 and Homer3, but not Homer1, have been shown to bind to nuclear factor of activated T cells (NFAT) and serve as negative regulators of NFAT-dependent signaling in T cells [].This entry represents the N-terminal EVH1 domain found in the Homer family members [, ].
Homer (also known as Vesl) family members, including Homer1/2/3, are synaptic scaffolding proteins that regulate localisation of group 1 metabotropic glutamate receptors (mGluRs), which are known to play major roles in neural signal transduction. Homer family members contain the EVH1 domain at the N terminus for receptor binding, two leucine zipper motifs at the C terminus for clustering, and a linking region whose function is unclear. Besides binding to mGluR, Homer family members also recognise the PPXXF motif found in other binding partners []. Homer2 and Homer3, but not Homer1, have been shown to bind to nuclear factor of activated T cells (NFAT) and serve as negative regulators of NFAT-dependent signaling in T cells [].
