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Search results 401 to 464 out of 464 for Cry1

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Type Details Score
Publication
18454201 | J:319841
First Author: Liu AC
Year: 2008
Journal: PLoS Genet
Title: Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms.
Volume: 4
Issue: 2
Pages: e1000023
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Publication
29750810 | J:263234
First Author: Ramanathan C
Year: 2018
Journal: PLoS Genet
Title: mTOR signaling regulates central and peripheral circadian clock function.
Volume: 14
Issue: 5
Pages: e1007369
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Publication
28973913 | J:252914
First Author: Yoo SH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Volume: 114
Issue: 42
Pages: E8855-E8864
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Publication
19401184 | J:148090
 
First Author: Kaneko K
Year: 2009
Journal: Brain Res
Title: Obesity alters circadian expressions of molecular clock genes in the brainstem.
Volume: 1263
Pages: 58-68
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Publication
20668203 | J:162853
First Author: Maywood ES
Year: 2010
Journal: J Neurosci
Title: Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.
Volume: 30
Issue: 30
Pages: 10199-204
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Publication
10938103 | J:63933
First Author: Shearman LP
Year: 2000
Journal: Mol Cell Biol
Title: Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.
Volume: 20
Issue: 17
Pages: 6269-75
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Publication
23771028 | J:202149
First Author: Powell WT
Year: 2013
Journal: Hum Mol Genet
Title: A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure.
Volume: 22
Issue: 21
Pages: 4318-28
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Publication
11804325 | J:74040
First Author: Eun BK
Year: 2001
Journal: Mol Cells
Title: Cloning and expression of cryptochrome2 cDNA in the rat.
Volume: 12
Issue: 3
Pages: 286-91
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Publication
12483227 | J:81183
First Author: Etchegaray JP
Year: 2003
Journal: Nature
Title: Rhythmic histone acetylation underlies transcription in the mammalian circadian clock.
Volume: 421
Issue: 6919
Pages: 177-82
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Publication
17660446 | J:127130
First Author: Chen-Goodspeed M
Year: 2007
Journal: J Biol Rhythms
Title: Tumor suppression and circadian function.
Volume: 22
Issue: 4
Pages: 291-8
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Publication
31515273 | J:283068
First Author: Garg A
Year: 2019
Journal: J Biol Chem
Title: Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein.
Volume: 294
Issue: 45
Pages: 16604-16619
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Publication
24085301 | J:205916
First Author: Yumimoto K
Year: 2013
Journal: J Biol Chem
Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Volume: 288
Issue: 45
Pages: 32766-76
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Publication
32700769 | J:298817
First Author: Hassan SA
Year: 2021
Journal: Int J Cancer
Title: Time-dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and healthy liver of a transgenic mouse model.
Volume: 148
Issue: 1
Pages: 226-237
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Publication
23292171 | J:333593
First Author: Hashinaga T
Year: 2013
Journal: Endocr J
Title: Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome.
Volume: 60
Issue: 4
Pages: 483-92
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Publication
34954114 | J:319806
 
First Author: Oda Y
Year: 2022
Journal: Neurosci Lett
Title: Role of heterozygous and homozygous alleles in cryptochrome-deficient mice.
Volume: 772
Pages: 136415
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Protein
A0A494BBJ6
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Publication
23443664 | J:197826
First Author: Zmrzljak UP
Year: 2013
Journal: J Biol Chem
Title: Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.
Volume: 288
Issue: 15
Pages: 10318-27
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Publication
22039518 | J:179726
First Author: Mongrain V
Year: 2011
Journal: PLoS One
Title: Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
Volume: 6
Issue: 10
Pages: e26622
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Protein
A0A494B987
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q3U1J4
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
Q9D906
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
A0A0A0MQN4
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3ULS8
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: true
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Protein
S4R2T5
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q3TM87
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q3TAB9
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q91YC8
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
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Publication
17204848 | -
First Author: Meijer WH
Year: 2007
Journal: Autophagy
Title: ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes.
Volume: 3
Issue: 2
Pages: 106-16
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Publication
14706636 | -
First Author: Fujiwara H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.
Volume: 313
Issue: 4
Pages: 962-8
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Publication
19819873 | -
First Author: Maruyama M
Year: 2009
Journal: J Biol Chem
Title: Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.
Volume: 284
Issue: 50
Pages: 34692-702
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Publication
20531381 | -
First Author: Haroon N
Year: 2010
Journal: Nat Rev Rheumatol
Title: Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.
Volume: 6
Issue: 8
Pages: 461-7
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Publication
17525158 | -
First Author: Maruyama M
Year: 2007
Journal: J Biol Chem
Title: Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.
Volume: 282
Issue: 28
Pages: 20088-96
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Publication
17346152 | -
First Author: Luan Y
Year: 2007
Journal: Curr Med Chem
Title: The structure and main functions of aminopeptidase N.
Volume: 14
Issue: 6
Pages: 639-47
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Publication
21205077 | -
First Author: Wickström M
Year: 2011
Journal: Cancer Sci
Title: Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Volume: 102
Issue: 3
Pages: 501-8
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Publication
21210704 | -
First Author: Likitvivatanavong S
Year: 2011
Journal: J Agric Food Chem
Title: Multiple receptors as targets of Cry toxins in mosquitoes.
Volume: 59
Issue: 7
Pages: 2829-38
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Protein Domain
IPR034016 | M1_APN-typ
Type: Family
Description: This M1 peptidase family includes eukaryotic and bacterial members: aminopeptidase N (APN; MEROPS identifier M01.001), aminopeptidase Q (APQ, laeverin; MEROPS identifier M01.026) [, ], endoplasmic reticulum aminopeptidase 1 (ERAP1; MEROPS identifier M01.018) []as well as tricorn interacting factor F3 (MEROPS identifier M01.021).Aminopeptidase N (APN; CD13; Alanyl aminopeptidase; ), a type II integral membrane protease, consists of a small N-terminal cytoplasmic domain, a single transmembrane domain, and a large extracellular ectodomain that contains the active site. It preferentially cleaves neutral amino acids from the N terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs [, ].ERAP1 also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP) or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2 (MEROPS identifier M01.024), for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors [].The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position [].APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation []. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities.APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection []. Insect APNs (MEROPS identifiers M01.013 and M01.030) are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established [].
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Publication
15893768 | -
First Author: Kyrieleis OJ
Year: 2005
Journal: J Mol Biol
Title: Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
Volume: 349
Issue: 4
Pages: 787-800
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Protein
P97449
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Protein
Q2KHK3
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
P16406
Organism: Mus musculus/domesticus
Length: 945  
Fragment?: false
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Protein
Q8C129
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
Q11011
Organism: Mus musculus/domesticus
Length: 920  
Fragment?: false
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Protein
Q8K093
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
F7ANF4
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein
A0A3Q4L2Z6
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q3TB69
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
Q8BZN0
Organism: Mus musculus/domesticus
Length: 841  
Fragment?: true
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Protein
Q8BZ14
Organism: Mus musculus/domesticus
Length: 691  
Fragment?: false
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Protein
A0A6I8MX30
Organism: Mus musculus/domesticus
Length: 1066  
Fragment?: false
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Protein
E9Q6F4
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
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Protein
Q6NY09
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
E9QJR0
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: false
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Protein
Q8C9W5
Organism: Mus musculus/domesticus
Length: 694  
Fragment?: true
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Protein
Q8CD51
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: true
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Protein
E9Q039
Organism: Mus musculus/domesticus
Length: 889  
Fragment?: false
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Protein
F7B9G4
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: true
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Protein
Q3TTA8
Organism: Mus musculus/domesticus
Length: 792  
Fragment?: true
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Protein
F6QYF8
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: true
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Protein
Q3UP74
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Protein
Q52JJ6
Organism: Mus musculus/domesticus
Length: 945  
Fragment?: false
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Publication
25910181 | -
First Author: Gindt YM
Year: 2015
Journal: Biochemistry
Title: Binding of Substrate Locks the Electrochemistry of CRY-DASH into DNA Repair.
Volume: 54
Issue: 18
Pages: 2802-5
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Publication
26352435 | -
First Author: Mei Q
Year: 2015
Journal: PLoS One
Title: Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes.
Volume: 10
Issue: 9
Pages: e0135940
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Protein
Q9EQH2
Organism: Mus musculus/domesticus
Length: 930  
Fragment?: false
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Protein
Q8C4S7
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom