Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:7541506 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-10-24 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7543050 |
Age: |
postnatal week 9 |
|
|
Specimen Label: |
Ad |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
8A |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729028 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
Note: |
Expression was detected in the saccular wall. |
Specimen Label: |
8A |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7541522 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-10-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2828125 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:7542999 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
2A E17.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7541522 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-10-24 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2828128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7542999 |
Age: |
postnatal week 9 |
|
|
Specimen Label: |
2A AD |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
8A |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729328 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
Note: |
Expression was detected in the utricular wall. |
Specimen Label: |
8A |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
Note: |
Strong immunoreactivity was observed at the Reissner's membrane. |
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759728 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
Note: |
The laminar surface of the stria marginal cells showed strong immunoreactivity. |
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3623984 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-06-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:160403 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3623988 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
4B Morula |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3516628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3623984 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-06-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3623988 |
Age: |
postnatal adult |
|
|
Specimen Label: |
4B Oocyte |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5461370 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2013-01-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2966128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5461486 |
Age: |
postnatal adult |
Image: |
3D |
|
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3623984 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2006-06-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3623988 |
Age: |
postnatal |
|
|
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7506226 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-07-11 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3582728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7506301 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
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Sci Rep |
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18166 |
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•
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2915-21 |
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•
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•
•
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•
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Publication |
First Author: |
Sohara E |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice. |
Volume: |
1758 |
Issue: |
8 |
Pages: |
1106-10 |
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•
•
•
•
•
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Publication |
First Author: |
Verta R |
Year: |
2021 |
Journal: |
Biomolecules |
Title: |
The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice. |
Volume: |
11 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sonntag Y |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. |
Volume: |
294 |
Issue: |
18 |
Pages: |
7377-7387 |
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•
•
•
•
•
|
Publication |
First Author: |
Ishibashi K |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. |
Volume: |
272 |
Issue: |
33 |
Pages: |
20782-6 |
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•
•
•
•
•
|
Publication |
First Author: |
Kuriyama H |
Year: |
1997 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. |
Volume: |
241 |
Issue: |
1 |
Pages: |
53-8 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-7 (AQP7) contains the 6 transmembrane domains and intracellular N and C termini characteristic of aquaporins []. AQP7 is expressed abundantly in rat testis seminiferous tubules, in cells that appear to be late spermatids []. It expressed predominantly in human adipose tissue [], and in Xenopus laevis (African clawed frog) oocytes increased the coefficients of osmotic water permeability approximately 7-fold, and also facilitated the uptake of glycerol, suggesting that this aquaporin participates in glycerol transport in adipocytes [].Synonym(s): AQUAPORIN 7-LIKE,AQUAPORIN, ADIPOSE,AQP7L |
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•
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Publication |
First Author: |
Engevik AC |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Loss of MYO5B Leads to Reductions in Na(+) Absorption With Maintenance of CFTR-Dependent Cl(-) Secretion in Enterocytes. |
Volume: |
155 |
Issue: |
6 |
Pages: |
1883-1897.e10 |
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•
•
•
•
•
|
Publication |
First Author: |
Ishibashi K |
Year: |
1998 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. |
Volume: |
244 |
Issue: |
1 |
Pages: |
268-74 |
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•
•
•
•
•
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Publication |
First Author: |
Carbrey JM |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. |
Volume: |
100 |
Issue: |
5 |
Pages: |
2945-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gotfryd K |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Human adipose glycerol flux is regulated by a pH gate in AQP10. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4749 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-9 was identified from human leukocytes by homology cloning []. AQP9 has unusually broad solute permeability. It is expressed in hepatocyte plasma membranes and also in lung, small intestine and spleen cells []. Expression of AQP9 in liver was induced up to 20-fold in rats fasted for 24 to 96 hours, and the AQP9 level gradually declined after re-feeding []. AQP9 shares greater sequence identity with AQP3 and AQP7 than with other members of the family, suggesting that these 3 proteins belong to a subfamily. |
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|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
321
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
|
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Harries WE |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The channel architecture of aquaporin 0 at a 2.2-A resolution. |
Volume: |
101 |
Issue: |
39 |
Pages: |
14045-50 |
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•
•
•
•
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Publication |
First Author: |
King LS |
Year: |
2004 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
From structure to disease: the evolving tale of aquaporin biology. |
Volume: |
5 |
Issue: |
9 |
Pages: |
687-98 |
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•
•
•
•
•
|
Publication |
First Author: |
Tanghe A |
Year: |
2006 |
Journal: |
Trends Microbiol |
Title: |
Why do microorganisms have aquaporins? |
Volume: |
14 |
Issue: |
2 |
Pages: |
78-85 |
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•
•
•
•
•
|
Publication |
First Author: |
Savage DF |
Year: |
2003 |
Journal: |
PLoS Biol |
Title: |
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. |
Volume: |
1 |
Issue: |
3 |
Pages: |
E72 |
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•
•
•
•
•
|
Publication |
First Author: |
Gorelick DA |
Year: |
2006 |
Journal: |
BMC Biochem |
Title: |
Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. |
Volume: |
7 |
|
Pages: |
14 |
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•
•
•
•
•
|
Publication |
First Author: |
Borgnia M |
Year: |
1999 |
Journal: |
Annu Rev Biochem |
Title: |
Cellular and molecular biology of the aquaporin water channels. |
Volume: |
68 |
|
Pages: |
425-58 |
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•
•
•
•
•
|
Publication |
First Author: |
Sui H |
Year: |
2001 |
Journal: |
Nature |
Title: |
Structural basis of water-specific transport through the AQP1 water channel. |
Volume: |
414 |
Issue: |
6866 |
Pages: |
872-8 |
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•
•
•
•
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