|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1701 to 1800 out of 2445 for Il6

0.048s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
First Author: Rabinovitch M
Year: 2014
Journal: Circ Res
Title: Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
Volume: 115
Issue: 1
Pages: 165-75
Publication
First Author: Yu Q
Year: 2019
Journal: Circulation
Title: BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
Volume: 139
Issue: 19
Pages: 2238-2255
Strain
Attribute String: congenic, transgenic, mutant strain, major histocompatibility congenic
Allele
Name: transgene insertion 56, Ken Watanabe
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Genotype
Symbol: Tg(Scgb1a1-IL6)9Flv/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(H2-K-IL6)2Srj/?
Background: B6.Cg-Tg(H2-K-IL6)2Srj
Zygosity: ot
Has Mutant Allele: true
MP Term
MP Term
Publication
First Author: Esparza-Moltó PB
Year: 2021
Journal: PLoS Biol
Title: Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.
Volume: 19
Issue: 5
Pages: e3001252
Publication
First Author: Aly M
Year: 2007
Journal: Genes Immun
Title: Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis.
Volume: 8
Issue: 3
Pages: 193-204
Publication  
First Author: De Maeyer E
Year: 1975
Journal: Immunogenetics
Title: Effect of mouse genotype on interferon production. I. Lines congenic at the If-1 locus.
Volume: 1
Pages: 438-443
Publication  
First Author: Zhong G
Year: 2021
Journal: Int Immunopharmacol
Title: IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa.
Volume: 99
Pages: 107980
Heritable Phenotypic Marker
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
Publication
First Author: de Maeyer E
Year: 1969
Journal: J Virol
Title: Gene with quantitative effect on circulating interferon induced by Newcastle disease virus.
Volume: 3
Issue: 5
Pages: 506-12
Publication
First Author: Toth LA
Year: 1996
Journal: J Interferon Cytokine Res
Title: Strain differences in the somnogenic effects of interferon inducers in mice.
Volume: 16
Issue: 12
Pages: 1065-72
Publication
First Author: Mobraaten LE
Year: 1984
Journal: J Hered
Title: Location of histocompatibility and interferon loci on chromosome 3 of the mouse.
Volume: 75
Issue: 3
Pages: 233-4
Publication
First Author: Zawatzky R
Year: 1982
Journal: J Infect Dis
Title: The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1.
Volume: 146
Issue: 3
Pages: 405-10
Publication
First Author: Zawatzky R
Year: 1991
Journal: J Virol
Title: Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages.
Volume: 65
Issue: 9
Pages: 4839-46
Publication
First Author: Raj NB
Year: 1992
Journal: J Immunol
Title: Mouse genotype affects inducible expression of cytokine genes.
Volume: 148
Issue: 6
Pages: 1934-40
Publication
First Author: Zawatzky R
Year: 1992
Journal: Res Immunol
Title: Downregulation of Newcastle disease virus (NDV)-dependent IFN-alpha/beta production in macrophages by IFN-induced gene products of the locus If-1.
Volume: 143
Issue: 1
Pages: 57-63
Publication
First Author: Lai MC
Year: 1994
Journal: Antiviral Res
Title: Differential expression patterns of type I interferon subtypes in mouse embryo fibroblasts: influence of genotype and viral inducer.
Volume: 24
Issue: 4
Pages: 327-40
Publication  
First Author: De Maeyer E
Year: 1975
Journal: Immunogenetics
Title: Effect of mouse genotype on interferon production. II. Distribution of If-1 alleles among inbred strains and transfer of phenotype by grafting bone marrow cells.
Volume: 2
Pages: 151-160
ncRNA Gene
Type: lncRNA_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
lncRNA Gene
Type: lncRNA_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication
First Author: Sabikunnahar B
Year: 2023
Journal: J Immunol
Title: Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein.
Volume: 210
Issue: 6
Pages: 807-819
Publication
First Author: Sabikunnahar B
Year: 2024
Journal: Physiol Rep
Title: LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
Volume: 12
Issue: 1
Pages: e15901
Publication    
First Author: Gure AO
Year: 1997
Journal: GenBank Submission
Title: Mus musculus putative TNF-resistance related protein mRNA, complete cds
Pages: U90926
HT Experiment
Series Id: GSE29311
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Paul PR
Year: 1987
Journal: Biochem Genet
Title: Analysis of the mouse Amy locus in recombinant inbred mouse strains.
Volume: 25
Issue: 7-8
Pages: 569-79
Publication  
First Author: Samokhin AO
Year: 2018
Journal: Sci Transl Med
Title: NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Volume: 10
Issue: 445
Publication
First Author: Kuhn C
Year: 2000
Journal: Chest
Title: Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung.
Volume: 117
Issue: 5 Suppl 1
Pages: 260S-2S
Publication
First Author: Wall JS
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy.
Volume: 115
Issue: 46
Pages: E10839-E10848
Publication
First Author: Solomon A
Year: 1999
Journal: Am J Pathol
Title: Transgenic mouse model of AA amyloidosis.
Volume: 154
Issue: 4
Pages: 1267-72
Publication
First Author: Peters M
Year: 1996
Journal: Immunol Lett
Title: The function of the soluble IL-6 receptor in vivo.
Volume: 54
Issue: 2-3
Pages: 177-84
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: coisogenic, transgenic
Publication
First Author: Wall JS
Year: 2008
Journal: Comp Med
Title: Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice.
Volume: 58
Issue: 6
Pages: 542-50
Strain
Attribute String: transgenic, coisogenic
Strain
Attribute String: congenic, transgenic
Publication      
First Author: Kishimoto T
Year: 2008
Journal: MGI Direct Data Submission
Title: Generation of H2-L-IL6 transgenic mice
Publication
First Author: Katsume A
Year: 2002
Journal: Cytokine
Title: Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
Volume: 20
Issue: 6
Pages: 304-11
Publication
First Author: Wall JS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.
Volume: 108
Issue: 34
Pages: E586-94
Strain
Attribute String: mutant strain, coisogenic, transgenic
Strain
Attribute String: mutant strain, coisogenic, transgenic
Genotype
Symbol: Tg(H2-L-IL6)1Kish/Tg(H2-L-IL6)1Kish
Background: C57BL/6-Tg(H2-L-IL6)1Kish
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: C57BL/6-Tg(H2-L-IL6)46Kish
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: involves: BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: C.B6-Tg(H2-L-IL6)46Kish
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(Mt1-IL6)28Gci/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Il6ra/Il6ra Tg(H2-L-IL6)40Csk/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Kozak CA
Year: 1999
Journal: Mamm Genome
Title: Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Volume: 10
Issue: 9
Pages: 853-7
Publication  
First Author: Liu E
Year: 2021
Journal: Front Cell Dev Biol
Title: ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.
Volume: 9
Pages: 710967
Publication
First Author: Zawatzky R
Year: 1982
Journal: J Gen Virol
Title: An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1.
Volume: 63
Issue: 2
Pages: 325-32
Publication
First Author: Negi V
Year: 2021
Journal: Sci Adv
Title: Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.
Volume: 7
Issue: 43
Pages: eabh3794
Genotype
Symbol: Il6/Il6 Tg(H2-K-IL6)2Srj/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
MP Term
MP Term
Publication
First Author: Sutherland GR
Year: 1988
Journal: Hum Genet
Title: Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
Volume: 79
Issue: 4
Pages: 335-7
Protein Domain
Type: Family
Description: Interleukin-6 (IL6), also refered to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of biological functions []. It plays an essential role in the finaldifferentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasmacytoma growth, nerve cell differentiation and, in hepatocytes, acute phase reactants [, ].A number of other cytokines may be grouped with IL6 on the basis of sequence similarity [, , ]: these include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis by affecting the production, differentiation and function of 2 related white cell groups in the blood []. MGF also acts in hematopoiesis, stimulating proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.
Publication
First Author: Matsushita K
Year: 2009
Journal: Nature
Title: Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Volume: 458
Issue: 7242
Pages: 1185-90
Publication
First Author: Garg AV
Year: 2015
Journal: Immunity
Title: MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.
Volume: 43
Issue: 3
Pages: 475-87
Publication  
First Author: Li DD
Year: 2021
Journal: JCI Insight
Title: RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1.
Volume: 6
Issue: 13
Publication
First Author: Uehata T
Year: 2013
Journal: Cell
Title: Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.
Volume: 153
Issue: 5
Pages: 1036-49
Publication  
First Author: Duncan K
Year: 2013
Journal: Blood Cancer J
Title: (18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.
Volume: 3
Pages: e165
Publication  
First Author: Rosean TR
Year: 2016
Journal: Blood Cancer J
Title: KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Volume: 6
Pages: e398
Publication
First Author: Lütticken C
Year: 1991
Journal: FEBS Lett
Title: Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.
Volume: 282
Issue: 2
Pages: 265-7
Publication
First Author: Hirano T
Year: 1986
Journal: Nature
Title: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.
Volume: 324
Issue: 6092
Pages: 73-6
Publication
First Author: Enzler T
Year: 2009
Journal: J Immunol
Title: MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Volume: 183
Issue: 6
Pages: 3831-8
Publication
First Author: Castelnau PA
Year: 1997
Journal: Neurosci Lett
Title: Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in transgenic mice expressing interleukin-6 in the brain.
Volume: 234
Issue: 1
Pages: 15-8
Publication
First Author: Sieburth D
Year: 1992
Journal: Genomics
Title: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
Volume: 14
Issue: 1
Pages: 59-62
Publication
First Author: Elliott RW
Year: 1979
Journal: Genetics
Title: Use of two-dimensional electrophoresis to identify and map new mouse genes.
Volume: 91
Issue: 2
Pages: 295-308
Publication
First Author: Slate DL
Year: 1979
Journal: Pharmacol Ther
Title: Genetics of the interferon system.
Volume: 4
Issue: 1
Pages: 221-30
Publication
First Author: Omiya S
Year: 2020
Journal: Circulation
Title: Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.
Volume: 141
Issue: 8
Pages: 667-677
Publication
First Author: Bommert KS
Year: 2013
Journal: Leukemia
Title: The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival.
Volume: 27
Issue: 2
Pages: 441-50
Publication
First Author: White K
Year: 2015
Journal: EMBO Mol Med
Title: Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
Volume: 7
Issue: 6
Pages: 695-713
Publication
First Author: Andriessen EMMA
Year: 2021
Journal: EMBO Mol Med
Title: Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation.
Volume: 13
Issue: 5
Pages: e11754
Publication
First Author: Mawambo G
Year: 2023
Journal: J Neuroinflammation
Title: HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
Volume: 20
Issue: 1
Pages: 145
Publication
First Author: Hung LY
Year: 2021
Journal: Am J Pathol
Title: Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium-Induced Colitis.
Volume: 191
Issue: 2
Pages: 266-273
Publication
First Author: Sun JY
Year: 2023
Journal: Sci Adv
Title: An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Volume: 9
Issue: 14
Pages: eade4110
Publication
First Author: Irazoki A
Year: 2023
Journal: Nat Commun
Title: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.
Volume: 14
Issue: 1
Pages: 108
Publication
First Author: Thouverey C
Year: 2015
Journal: Endocrinology
Title: Ablation of p38α MAPK Signaling in Osteoblast Lineage Cells Protects Mice From Bone Loss Induced by Estrogen Deficiency.
Volume: 156
Issue: 12
Pages: 4377-87