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Search results 301 to 379 out of 379 for Shc1

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0.029s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:5613974 | B6.129S-Tg(EEF1A1-SHC1)1Ravi/J
Attribute String: transgenic, mutant strain, congenic
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Protein Coding Gene
MGI:97599 | Prkce
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P16054
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: false
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Protein Domain
IPR029591 | SHC2
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].This entry represents Shc2.
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Protein Coding Gene
MGI:95411 | Erbb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919170 | Epgn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61526
Organism: Mus musculus/domesticus
Length: 1339  
Fragment?: false
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Protein
Q924X1
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Strain
MGI:5582476 | B6.129-Tg(EEF1A1-SHC1*)1Ravi/J
Attribute String: transgenic, mutant strain, congenic
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Genotype
Genotype
Symbol: Tg(EEF1A1-SHC1*)1Ravi/? Tg(Lck-cre)1Cwi/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
Q3URY3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Publication
8808684 | -
First Author: Nakamura T
Year: 1996
Journal: Oncogene
Title: N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
Volume: 13
Issue: 6
Pages: 1111-21
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Protein Domain
IPR029593 | Shc3/ShcC/N-Shc
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc3 (also known as NShc from neuronal Shc) mediates neurotrophin and other neuronal signallings in the central nervous system [, ].
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Protein Coding Gene
MGI:104771 | Erbb4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95410 | Erbb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1097165 | Nrg3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098246 | Nrg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88068 | Areg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98724 | Tgfa
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96083 | Nrg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70424
Organism: Mus musculus/domesticus
Length: 1256  
Fragment?: false
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Protein
Q61527
Organism: Mus musculus/domesticus
Length: 1308  
Fragment?: false
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Protein
P31955
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
O35181
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
P56974
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
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Protein
P48030
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
A0A140LHZ9
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Publication
14665640 | -
First Author: Audero E
Year: 2004
Journal: J Biol Chem
Title: Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
Volume: 279
Issue: 13
Pages: 13224-33
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Publication
23277357 | -
First Author: Northey JJ
Year: 2013
Journal: J Biol Chem
Title: Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
Volume: 288
Issue: 7
Pages: 5210-22
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Protein Domain
IPR029586 | Shc1/ShcA
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc1 (ShcA) adaptor transduces phosphotyrosine-dependent signals downstream of receptor tyrosine kinases (RTK) and non-RTKs, which regulates signalling pathways in breast cancer cells []. Its SH2 domain is critical for tumour survival during mammary tumorigenesis [], while its PTB domain functions as a biological sensor of phosphotyrosine signalling during breast cancer progression []. Shc1 is required for transforming growth factor beta (TGF-beta)-induced breast cancer cell migration, invasion, and metastasis []. It is also involved in signalling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis [].
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Publication
11607835 | -
First Author: Ravichandran KS
Year: 2001
Journal: Oncogene
Title: Signaling via Shc family adapter proteins.
Volume: 20
Issue: 44
Pages: 6322-30
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Publication
8760305 | J:34966
First Author: Pelicci G
Year: 1996
Journal: Oncogene
Title: A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
Volume: 13
Issue: 3
Pages: 633-41
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Protein Coding Gene
MGI:97598 | Prkcd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96070 | Hbegf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95290 | Egf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107508 | Ereg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99439 | Btc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q05928
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
P01132
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Protein
P28867
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
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Protein
Q06186
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q61521
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Genotype
Genotype
Symbol: Tg(EEF1A1-SHC1*)1Ravi/? Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
17452444 | J:122785
First Author: Jones N
Year: 2007
Journal: Mol Cell Biol
Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Volume: 27
Issue: 13
Pages: 4759-73
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Publication
22948967 | J:194646
First Author: Turco MY
Year: 2012
Journal: Stem Cells
Title: Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Volume: 30
Issue: 11
Pages: 2423-36
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Publication
24430869 | -
First Author: Wills MK
Year: 2014
Journal: Mol Biol Cell
Title: The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.
Volume: 25
Issue: 6
Pages: 739-52
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Publication
7544002 | -
First Author: Zhou MM
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Volume: 92
Issue: 17
Pages: 7784-8
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Protein Domain
IPR035676 | SHC_SH2
Type: Domain
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].SHC is composed of an N-terminal domain that interacts with proteins containing phosphorylated tyrosines, a (glycine/proline)-rich collagen-homology domain that contains the phosphorylated binding site, and a C-terminal SH2 domain. SH2 has been shown to interact with the tyrosine-phosphorylated receptors of EGF and PDGF and with the tyrosine-phosphorylated C chain of the T-cell receptor, providing one of the mechanisms of T-cell-mediated Ras activation []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Protein Domain
IPR029596 | SHC4
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].A fourth Shc family protein, ShcD/Shc4, is expressed in adult brain and skeletal muscle. ShcD can associate via its PTB domain with the phosphorylated muscle-specific kinase (MuSK) receptor tyrosine kinase and undergo tyrosine phosphorylation downstream of activated MuSK. Therefore, ShcD may mediate a specific aspect of signalling downstream of the MuSK receptor []. ShcD also interacts with EGFR receptor (epidermal growth factor receptor) and facilitates its ligand-independent phosphorylation []. ShcD has been shown to be a modulator in the transition of embryonic stem cell (ESC) to epiblast stem cells (EpiSCs), the initial step for ESCs to commit to differentiation [].
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Protein Coding Gene
MGI:95294 | Egfr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97595 | Prkca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P20444
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
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Protein
Q01279
Organism: Mus musculus/domesticus
Length: 1210  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62245
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
D3Z2I8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
D3YZV5
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
D3YXZ9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
D3Z5U6
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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Protein
P98083
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
Q3ZAX3
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
A0A1Y7VKQ1
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Protein
Q61120
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q6S5L9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q8BMC3
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
A0A5F8MPM1
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
A2AUN0
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
Q8CB26
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Publication
10398925 | -
First Author: Grucza RA
Year: 1999
Journal: Med Res Rev
Title: SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
Volume: 19
Issue: 4
Pages: 273-93
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Publication
19273114 | -
 
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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