Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors []. This C-terminal region is found only in the Nab1 subfamily. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
486
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
485
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
456
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Swirnoff AH |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. |
Volume: |
18 |
Issue: |
1 |
Pages: |
512-24 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors []. This entry represents the N-terminal NAB domain, which interacts with the EGR1 inhibitory domain (R1) []. It may also mediate multimerisation. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
46
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sevetson BR |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene. |
Volume: |
275 |
Issue: |
13 |
Pages: |
9749-57 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Terriente FĂ©lix J |
Year: |
2007 |
Journal: |
Development |
Title: |
Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development. |
Volume: |
134 |
Issue: |
10 |
Pages: |
1845-52 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors []. This entry represents a NAB domain 2 of the protein. It is necessary for transcriptional repression by the Nab proteins []. It is also required for transcription activation by Nab proteins at Nab-activated promoters []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors []. This entry represents a NAB domain 2 of the protein. It is necessary for transcriptional repression by the Nab proteins []. It is also required for transcription activation by Nab proteins at Nab-activated promoters []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Proteins in this family are transcriptional regulators, including Nab (NGFI-A-binding protein) from Drosophila and Nab1/2 from mammals. Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors []. Drosophila Nab controls the activity of zinc-finger transcription factors, such as Squeeze and Rotund, in Drosophila development []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
525
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
342
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
525
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kayam G |
Year: |
2013 |
Journal: |
Development |
Title: |
A novel role for Pax6 in the segmental organization of the hindbrain. |
Volume: |
140 |
Issue: |
10 |
Pages: |
2190-202 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
66
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Abou-Khalil B |
Year: |
2001 |
Journal: |
Neurology |
Title: |
Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation. |
Volume: |
57 |
Issue: |
12 |
Pages: |
2265-72 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in mostelectrically excitable cells []. They may exist in 3 states []: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated state, where the channel is closed and refractory to opening. Several different structurally and functionally distinct isoforms are found in mammals, coded for by a multigene family, these being responsible for the different types of sodium ion currents found in excitable tissues.There are nine pore-forming alpha subunit of voltage-gated sodium channels consisting of four membrane-embedded homologous domains (I-IV), each consisting of six α-helical segments (S1-S6), three cytoplasmic loops connecting the domains, and a cytoplasmic C-terminal tail. The S6 segments of the four domains form the inner surface of the pore, while the S4 segments bear clusters of basic residues that constitute the channel's voltage sensors [, , ].The SCN1A gene encodes the NaB1 channel and is particularly expressed inthe brain, but is also found in a variety of other tissues, ranging from theretina to the olfactory bulb. Epilepsy, a disorder of neuronalhyperexcitability, has been associated with altered kinetics of SCN1A, aswell as delayed inactivation of SCN2A [].This entry represents the alpha 1 subunits of the voltage-gated Na+ channel superfamily. For entries containing other members of this superfamily see , , . |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
500
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2009
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Noda M |
Year: |
1984 |
Journal: |
Nature |
Title: |
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. |
Volume: |
312 |
Issue: |
5990 |
Pages: |
121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
George AL Jr |
Year: |
1992 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family. |
Volume: |
89 |
Issue: |
11 |
Pages: |
4893-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldfarb M |
Year: |
2012 |
Journal: |
Cell Mol Life Sci |
Title: |
Voltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and block. |
Volume: |
69 |
Issue: |
7 |
Pages: |
1067-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaplan DI |
Year: |
2016 |
Journal: |
Cold Spring Harb Perspect Med |
Title: |
Role of Sodium Channels in Epilepsy. |
Volume: |
6 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sato C |
Year: |
1992 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Proposed tertiary structure of the sodium channel. |
Volume: |
186 |
Issue: |
2 |
Pages: |
1158-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|