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Search results 1 to 100 out of 403 for Pou4f3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: POU4F3 is a transcription factor that is linked to inherited progressive hearing loss in humans [, , ]. It has an important role in the maturation, differentiation and survival of cochlear hair cells [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 +/+ (top)
Specimen Label: 4c Pou4f3 +/+ (top)
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697423
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 -/- (top)
Note: Expression abolished in midbrain.
Specimen Label: 4c Pou4f3 -/- (top)
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 +/+ (middle)
Specimen Label: 4c Pou4f3 +/+ (middle)
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697423
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 -/- (middle)
Note: Expression abolished in midbrain.
Specimen Label: 4c Pou4f3 -/- (middle)
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 +/+ (bottom)
Specimen Label: 4c Pou4f3 +/+ (bottom)
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7492082
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697423
Stage: TS23
Assay Id: MGI:7492130
Age: embryonic day 15.5
Image: 4c Pou4f3 -/- (bottom)
Note: Expression abolished in midbrain.
Specimen Label: 4c Pou4f3 -/- (bottom)
Detected: false
Specimen Num: 6
Publication
First Author: Freitas ÉL
Year: 2014
Journal: Eur J Med Genet
Title: Deletion of the entire POU4F3 gene in a familial case of autosomal dominant non-syndromic hearing loss.
Volume: 57
Issue: 4
Pages: 125-8
Publication
First Author: Vahava O
Year: 1998
Journal: Science
Title: Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.
Volume: 279
Issue: 5358
Pages: 1950-4
Publication
First Author: Collin RW
Year: 2008
Journal: Hum Mutat
Title: Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding.
Volume: 29
Issue: 4
Pages: 545-54
Publication
First Author: Kim HJ
Year: 2013
Journal: PLoS One
Title: SNP linkage analysis and whole exome sequencing identify a novel POU4F3 mutation in autosomal dominant late-onset nonsyndromic hearing loss (DFNA15).
Volume: 8
Issue: 11
Pages: e79063
Publication  
First Author: Masuda M
Year: 2011
Journal: Neuroscience
Title: Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice.
Volume: 197
Pages: 48-64
Publication  
First Author: Fukui H
Year: 2012
Journal: Sci Rep
Title: BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.
Volume: 2
Pages: 838
Publication
First Author: Masuda M
Year: 2017
Journal: Mol Neurobiol
Title: The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells.
Volume: 54
Issue: 7
Pages: 5414-5426
Publication      
First Author: Frankel WN
Year: 1999
Journal: Personal Communication
Title: The mutant mouse dreidel (ddl) contains a mutation in the Pou4f3 gene
Protein
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: false
Publication
First Author: Walters BJ
Year: 2017
Journal: Cell Rep
Title: In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice.
Volume: 19
Issue: 2
Pages: 307-320
Publication
First Author: Hertzano R
Year: 2007
Journal: Eur J Neurosci
Title: Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
Volume: 25
Issue: 4
Pages: 999-1005
Publication
First Author: Hertzano R
Year: 2004
Journal: Hum Mol Genet
Title: Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene.
Volume: 13
Issue: 18
Pages: 2143-53
Publication    
First Author: Iyer AA
Year: 2022
Journal: Elife
Title: Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.
Volume: 11
Publication  
First Author: Yu HV
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism.
Volume: 118
Issue: 29
Publication
First Author: Towers ER
Year: 2011
Journal: J Cell Sci
Title: Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.
Volume: 124
Issue: Pt 7
Pages: 1145-55
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191126
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Pou4f3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191126
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Pou4f3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191126
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Pou4f3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191126
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Pou4f3
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191126
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Pou4f3
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191126
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Pou4f3
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6181033
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191126
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Pou4f3
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6402637
Assay Type: RNA in situ
Annotation Date: 2020-04-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3592127
Stage: TS27
Assay Id: MGI:6402642
Age: postnatal day 2
Image: 3C vestibule Pou4f3 mutant
Specimen Label: 3C vestibule Pou4f3 mutant
Detected: false
Specimen Num: 26
GXD Expression  
Probe: MGI:6402637
Assay Type: RNA in situ
Annotation Date: 2020-04-02
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6402642
Age: postnatal day 2
Image: 3C cochlea Pou4f3 mutant
Specimen Label: 3C cochlea Pou4f3 mutant
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:6402637
Assay Type: RNA in situ
Annotation Date: 2020-04-02
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3524727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6402642
Age: postnatal day 2
Image: 3C cochlea Pou4f3 mutant
Note: Expressed in hair cells.
Specimen Label: 3C cochlea Pou4f3 mutant
Detected: true
Specimen Num: 24
GXD Expression    
Probe: MGI:6402637
Assay Type: RNA in situ
Annotation Date: 2020-04-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1729527
Stage: TS27
Assay Id: MGI:6402642
Age: postnatal day 2
Image: 3C vestibule Pou4f3 mutant
Specimen Label: 3C vestibule Pou4f3 mutant
Detected: false
Specimen Num: 26
Publication      
First Author: Badea T
Year: 2011
Journal: MGI Direct Data Submission
Title: Creation of a conditional knock-in alkaline phosphatase reporter in Pou4f3
Publication
First Author: Frenz S
Year: 2015
Journal: Neuroreport
Title: Mosaic pattern of Cre recombinase expression in cochlear outer hair cells of the Brn3.1 Cre mouse.
Volume: 26
Issue: 6
Pages: 309-13
Publication
First Author: Qian ZJ
Year: 2020
Journal: Sci Rep
Title: Effects of cochlear hair cell ablation on spatial learning/memory.
Volume: 10
Issue: 1
Pages: 20687
Publication
First Author: Zhu GJ
Year: 2020
Journal: PLoS Genet
Title: Aldh inhibitor restores auditory function in a mouse model of human deafness.
Volume: 16
Issue: 9
Pages: e1009040
Publication
First Author: Tong L
Year: 2015
Journal: J Neurosci
Title: Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons.
Volume: 35
Issue: 20
Pages: 7878-91
Publication
First Author: Golub JS
Year: 2012
Journal: J Neurosci
Title: Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin.
Volume: 32
Issue: 43
Pages: 15093-105
Publication
First Author: Tornari C
Year: 2014
Journal: PLoS One
Title: Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
Volume: 9
Issue: 11
Pages: e112247
Publication  
First Author: Kaur T
Year: 2015
Journal: Front Cell Neurosci
Title: Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle.
Volume: 9
Pages: 150
Publication  
First Author: Hayashi Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Norrie disease protein is essential for cochlear hair cell maturation.
Volume: 118
Issue: 39
Publication
First Author: Atar O
Year: 2010
Journal: Neuroscience
Title: Anti-apoptotic factor z-Val-Ala-Asp-fluoromethylketone promotes the survival of cochlear hair cells in a mouse model for human deafness.
Volume: 168
Issue: 3
Pages: 851-7
Publication
First Author: Hesse K
Year: 2011
Journal: PLoS One
Title: AP-2δ is a crucial transcriptional regulator of the posterior midbrain.
Volume: 6
Issue: 8
Pages: e23483
Publication
First Author: Parmhans N
Year: 2021
Journal: J Comp Neurol
Title: Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.
Volume: 529
Issue: 8
Pages: 1926-1953
Publication
First Author: Duncan JS
Year: 2013
Journal: PLoS One
Title: Continued expression of GATA3 is necessary for cochlear neurosensory development.
Volume: 8
Issue: 4
Pages: e62046
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Guo H
Year: 2023
Journal: iScience
Title: Effects of focused ultrasound in a "clean" mouse model of ultrasonic neuromodulation.
Volume: 26
Issue: 12
Pages: 108372
Publication
First Author: González-Garrido A
Year: 2021
Journal: J Neurosci
Title: The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse.
Volume: 41
Issue: 37
Pages: 7779-7796
Publication
First Author: Mahrt EJ
Year: 2013
Journal: J Neurosci
Title: Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience.
Volume: 33
Issue: 13
Pages: 5573-83
Publication  
First Author: Jáuregui EJ
Year: 2024
Journal: Front Neurol
Title: Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice.
Volume: 15
Pages: 1322647
Publication  
First Author: Kurioka T
Year: 2016
Journal: Neuroscience
Title: Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus.
Volume: 332
Pages: 242-57
Publication  
First Author: Lee S
Year: 2021
Journal: Neuroscience
Title: Scar Formation and Debris Elimination during Hair Cell Degeneration in the Adult DTR Mouse.
Volume: 453
Pages: 57-68
Publication  
First Author: Xiang M
Year: 2003
Journal: BMC Neurosci
Title: Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
Volume: 4
Pages: 2
Publication
First Author: Murakami DM
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Evidence for vestibular regulation of autonomic functions in a mouse genetic model.
Volume: 99
Issue: 26
Pages: 17078-82
Publication
First Author: Keithley EM
Year: 1999
Journal: Hear Res
Title: Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging.
Volume: 134
Issue: 1-2
Pages: 71-6
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185818
Stage: TS18
Assay Id: MGI:3040648
Age: embryonic day 11.0
Specimen Label: E11
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:3040648
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185823
Stage: TS23
Assay Id: MGI:3040648
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185825
Stage: TS25
Assay Id: MGI:3040648
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185826
Stage: TS26
Assay Id: MGI:3040648
Age: embryonic day 19.0
Specimen Label: E19
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185827
Stage: TS27
Assay Id: MGI:3040648
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185828
Stage: TS28
Assay Id: MGI:3040648
Age: postnatal adult
Specimen Label: adult
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619324
Stage: TS24
Assay Id: MGI:6514439
Age: embryonic day 16.0
Specimen Label: E16 wild-type
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619324
Stage: TS24
Assay Id: MGI:6514439
Age: embryonic day 16.0
Specimen Label: E16 ddl/ddl
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619326
Stage: TS26
Assay Id: MGI:6514439
Age: embryonic day 18.5
Specimen Label: E18.5 wild-type
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619326
Stage: TS26
Assay Id: MGI:6514439
Age: embryonic day 18.5
Specimen Label: E18.5 ddl/ddl
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524720
Stage: TS20
Assay Id: MGI:6514443
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524721
Stage: TS21
Assay Id: MGI:6514443
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524722
Stage: TS22
Assay Id: MGI:6514443
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524726
Stage: TS26
Assay Id: MGI:6514443
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 5