MED26 isa subunit of Mediator, a complex involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. MED26 plays a role in the switch between the initiation and elongation phases of RNA Polymerase II-mediated transcription process [].
This entry represents the C-terminal domain of subunit 26 of the Mediator complex in eukaryotes (Med26). Med19 and Med26 act synergistically to mediate the interaction between Mediator and REST, a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes []. The C-terminal domain is critical and sufficient for its assembly into Mediator and its interaction with Pol II. The most highly conserved C-terminal amino acids are critical for these interactions because deletion of the last eight amino acids from the Med26 C terminus disrupted binding to Mediator and Pol II [].
This entry represents the middle domain of subunit 26 of Mediator (Med26). Med19 and Med26 act synergistically to mediate the interaction between Mediator and REST, a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes [].
