|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 600 out of 633 for Pik3ca

<< First    < Previous  |  Next >    Last >>
0.043s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Allele
Gt(ROSA)26Sor<tm1(CAG-PIK3CA*H1047R,-EGFP)Balj> | MGI:5052133
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mohamed Bentires-Alj
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter, RMCE-ready
•
•
•
•
•
Publication
37874915 | J:343415
First Author: Durham BH
Year: 2023
Journal: Blood Adv
Title: Mutant PIK3CA is a targetable driver alteration in histiocytic neoplasms.
Volume: 7
Issue: 23
Pages: 7319-7328
•
•
•
•
•
Publication
32559461 | J:290420
First Author: Koundouros N
Year: 2020
Journal: Cell
Title: Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Volume: 181
Issue: 7
Pages: 1596-1611.e27
•
•
•
•
•
Publication
21324922 | J:170898
First Author: Adams JR
Year: 2011
Journal: Cancer Res
Title: Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.
Volume: 71
Issue: 7
Pages: 2706-17
•
•
•
•
•
Publication
31996845 | J:293352
First Author: Yu K
Year: 2020
Journal: Nature
Title: PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Volume: 578
Issue: 7793
Pages: 166-171
•
•
•
•
•
Publication
31112530 | J:337611
First Author: Sivaram N
Year: 2019
Journal: J Clin Invest
Title: Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.
Volume: 129
Issue: 8
Pages: 3264-3276
•
•
•
•
•
Publication
36353506 | J:330707
 
First Author: Marechal E
Year: 2022
Journal: Front Cell Dev Biol
Title: Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling.
Volume: 10
Pages: 1013001
•
•
•
•
•
Publication
36799863 | J:334877
First Author: Malik N
Year: 2023
Journal: Cancer Res
Title: Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.
Volume: 83
Issue: 8
Pages: 1280-1298
•
•
•
•
•
Publication
24576621 | J:210526
First Author: Roper J
Year: 2014
Journal: Cancer Lett
Title: Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Volume: 347
Issue: 2
Pages: 204-11
•
•
•
•
•
Publication
32112900 | J:286791
 
First Author: Niesen J
Year: 2020
Journal: Cancer Lett
Title: Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Volume: 477
Pages: 10-18
•
•
•
•
•
Publication
21482677 | J:173655
First Author: Meyer DS
Year: 2011
Journal: Cancer Res
Title: Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Volume: 71
Issue: 13
Pages: 4344-51
•
•
•
•
•
Publication
32436348 | J:339906
First Author: Tan MT
Year: 2020
Journal: Int J Exp Pathol
Title: A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Volume: 101
Issue: 1-2
Pages: 45-54
•
•
•
•
•
Publication
19029981 | J:142254
First Author: Engelman JA
Year: 2008
Journal: Nat Med
Title: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Volume: 14
Issue: 12
Pages: 1351-6
•
•
•
•
•
Publication
28442534 | J:246966
First Author: Riemer P
Year: 2017
Journal: J Cell Biol
Title: Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.
Volume: 216
Issue: 6
Pages: 1567-1577
•
•
•
•
•
Publication
30591517 | J:273211
First Author: Rodriguez-Laguna L
Year: 2019
Journal: J Exp Med
Title: Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly.
Volume: 216
Issue: 2
Pages: 407-418
•
•
•
•
•
DO Term
DOID:0081001 | Cowden syndrome 5
•
•
•
•
•
Publication
29858226 | J:262549
First Author: Triscott J
Year: 2018
Journal: Cancer Discov
Title: Prostate Power Play: Does Pik3ca Accelerate Pten-Deficient Cancer Progression?
Volume: 8
Issue: 6
Pages: 682-685
•
•
•
•
•
Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky> | MGI:4430527
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Klaus Rajewsky
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(CAG-cre/Esr1*)5Amc
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
DO Term
DOID:0080351 | CLOVES syndrome
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm2(Pik3ca)Egan> | MGI:5000473
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan> | MGI:5000472
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz | MGI:5526971
Name: transgene insertion 2239, Jean J Zhao
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
•
•
•
•
•
Publication
37272756 | J:339599
First Author: Cheng X
Year: 2023
Journal: Cancer Res
Title: Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21-CDK4/6-Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance.
Volume: 83
Issue: 17
Pages: 2839-2857
•
•
•
•
•
Publication
30753336 | J:288706
     
First Author: Ochiai M
Year: 2019
Journal: Carcinogenesis
Title: Kras-driven heterotopic tumor development from hepatobiliary organoids.
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa> | MGI:5510667
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Dieter Saur
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm3(Pik3ca*E545K)Egan> | MGI:7493251
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:6147057 | FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
Attribute String: mutant strain, congenic, targeted mutation
•
•
•
•
•
Strain
MGI:5052137 | FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/J
Attribute String: targeted mutation, mutant strain, congenic
•
•
•
•
•
Publication
30297712 | J:267569
First Author: Wu S
Year: 2018
Journal: Nat Commun
Title: SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells.
Volume: 9
Issue: 1
Pages: 4116
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm4(Pik3ca*E545K*H1047R)Egan> | MGI:7618564
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
Allele
Col1a1<tm29(CAG-Pik3ca*E545K,-luc2)Nki> | MGI:7451118
Name: collagen, type I, alpha 1; targeted mutation 29, The Netherlands Cancer Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
21822287 | J:175839
First Author: Liu P
Year: 2011
Journal: Nat Med
Title: Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.
Volume: 17
Issue: 9
Pages: 1116-20
•
•
•
•
•
Publication
27292631 | J:238306
First Author: Spangle JM
Year: 2016
Journal: Cell Rep
Title: PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
Volume: 15
Issue: 12
Pages: 2692-704
•
•
•
•
•
Publication
34941867 | J:317487
First Author: Reske JJ
Year: 2021
Journal: PLoS Genet
Title: Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.
Volume: 17
Issue: 12
Pages: e1009986
•
•
•
•
•
Publication
30003928 | J:264244
 
First Author: Liu XL
Year: 2018
Journal: Cancer Lett
Title: Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer.
Volume: 433
Pages: 273-282
•
•
•
•
•
Publication
32464345 | J:303124
 
First Author: Wilson MR
Year: 2020
Journal: Stem Cell Res
Title: Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
Volume: 46
Pages: 101849
•
•
•
•
•
Publication
29281825 | J:277093
First Author: D'Gama AM
Year: 2017
Journal: Cell Rep
Title: Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.
Volume: 21
Issue: 13
Pages: 3754-3766
•
•
•
•
•
Publication
33031100 | J:299982
 
First Author: Liu B
Year: 2021
Journal: J Clin Invest
Title: Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.
Volume: 131
Issue: 1
•
•
•
•
•
Strain
MGI:6147058 | FVB.129S6-Gt(ROSA)26Sor<tm3(Pik3ca*E545K)Egan>
Attribute String: mutant strain, congenic, targeted mutation
•
•
•
•
•
Allele
Tg(Myh6-Pik3ca)1Siz | MGI:3619921
Name: transgene insertion 1, Seigo Izumo
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Amhr2-Pik3ca*,-GFP)#Lzh | MGI:3832594
Name: transgene insertion, Lin Zhang
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Myh6-Pik3r1/PIK3CA)BSiz | MGI:3619920
Name: transgene insertion B, Seigo Izumo
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
28396358 | J:242495
First Author: Hanker AB
Year: 2017
Journal: Cancer Res
Title: Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer.
Volume: 77
Issue: 12
Pages: 3280-3292
•
•
•
•
•
Publication
20974681 | J:179541
First Author: Yang KC
Year: 2010
Journal: J Physiol
Title: Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.
Volume: 588
Issue: Pt 24
Pages: 5015-32
•
•
•
•
•
Publication
23028587 | J:191872
First Author: Li C
Year: 2012
Journal: PLoS One
Title: Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.
Volume: 7
Issue: 9
Pages: e44712
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Arid1a/Arid1a Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Arid1a/Arid1a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
34548333 | J:311807
First Author: Zundell JA
Year: 2021
Journal: Cancer Res
Title: Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
Volume: 81
Issue: 20
Pages: 5325-5335
•
•
•
•
•
Publication
31492885 | J:287759
First Author: Zhao B
Year: 2019
Journal: Nat Commun
Title: ARID1A promotes genomic stability through protecting telomere cohesion.
Volume: 10
Issue: 1
Pages: 4067
•
•
•
•
•
Publication
28737768 | J:246354
First Author: Bitler BG
Year: 2017
Journal: Nat Cell Biol
Title: ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Volume: 19
Issue: 8
Pages: 962-973
•
•
•
•
•
Publication
29590609 | J:270936
First Author: Fukumoto T
Year: 2018
Journal: Cell Rep
Title: Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.
Volume: 22
Issue: 13
Pages: 3393-3400
•
•
•
•
•
Publication
36963401 | J:334759
First Author: Zhou W
Year: 2023
Journal: Cancer Cell
Title: Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.
Volume: 41
Issue: 4
Pages: 740-756.e10
•
•
•
•
•
Publication
16627784 | J:122613
First Author: Sun H
Year: 2006
Journal: Circ Res
Title: Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling.
Volume: 98
Issue: 11
Pages: 1390-7
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-IGF1R)7Jmcm/? Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-IGF1R)7Jmcm/? Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-Akt1*T308D*S473D)1Siz/? Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Trp53/Trp53 Tg(MMTV-cre)#Tfln/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cela1-cre/ERT)1Dam/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H3c2/H3c2<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Acvr1/Acvr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
24899687 | J:213493
 
First Author: Guan B
Year: 2014
Journal: J Natl Cancer Inst
Title: Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis.
Volume: 106
Issue: 7
•
•
•
•
•
Publication
25544637 | J:218823
First Author: Costa C
Year: 2015
Journal: Cancer Cell
Title: Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Volume: 27
Issue: 1
Pages: 97-108
•
•
•
•
•
Publication
31551414 | J:279285
First Author: Wu RC
Year: 2019
Journal: Nat Commun
Title: Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer.
Volume: 10
Issue: 1
Pages: 4332
•
•
•
•
•
Publication
21474066 | J:310528
First Author: Kennedy AL
Year: 2011
Journal: Mol Cell
Title: Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Volume: 42
Issue: 1
Pages: 36-49
•
•
•
•
•
Publication
37172086 | J:335643
First Author: Bu W
Year: 2023
Journal: Sci Adv
Title: Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice.
Volume: 9
Issue: 19
Pages: eade0059
•
•
•
•
•
Publication
29899452 | J:264410
First Author: Venot Q
Year: 2018
Journal: Nature
Title: Targeted therapy in patients with PIK3CA-related overgrowth syndrome.
Volume: 558
Issue: 7711
Pages: 540-546
•
•
•
•
•
Publication
25458846 | J:219500
First Author: Gasser JA
Year: 2014
Journal: Mol Cell
Title: SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.
Volume: 56
Issue: 4
Pages: 595-607
•
•
•
•
•
Publication
26824656 | J:230647
First Author: Hu H
Year: 2016
Journal: Cell
Title: Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.
Volume: 164
Issue: 3
Pages: 433-46
•
•
•
•
•
Publication
33606974 | J:305188
First Author: Mukherjee R
Year: 2021
Journal: Mol Cell
Title: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.
Volume: 81
Issue: 4
Pages: 708-723.e5
•
•
•
•
•
Publication
33176148 | J:314399
First Author: Wilson MR
Year: 2020
Journal: Cell Rep
Title: ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.
Volume: 33
Issue: 6
Pages: 108366
•
•
•
•
•
Publication
31233030 | J:309462
   
First Author: Xiang D
Year: 2019
Journal: J Vis Exp
Title: Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland.
Issue: 148
•
•
•
•
•
Publication
23258573 | J:252072
First Author: Cooley N
Year: 2013
Journal: Circ Heart Fail
Title: No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy.
Volume: 6
Issue: 2
Pages: 318-25
•
•
•
•
•
Publication
26400062 | J:226775
First Author: Wright KL
Year: 2015
Journal: Cancer Res
Title: Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.
Volume: 75
Issue: 22
Pages: 4960-72
•
•
•
•
•
Publication
19122165 | J:146552
First Author: Rigor DL
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Volume: 296
Issue: 3
Pages: H566-72
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-Pik3ca)1Siz/? Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)1Mam/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)1Mam/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Acvr1/Acvr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H3c2/H3c2<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
24482365 | J:209151
First Author: Cui M
Year: 2014
Journal: Mol Cancer Res
Title: PTEN is a potent suppressor of small cell lung cancer.
Volume: 12
Issue: 5
Pages: 654-9
•
•
•
•
•
Publication
30975125 | J:291157
First Author: Cao H
Year: 2019
Journal: BMC Cancer
Title: Functional role of SGK3 in PI3K/Pten driven liver tumor development.
Volume: 19
Issue: 1
Pages: 343
•
•
•
•
•
Publication
34613809 | J:332934
First Author: Delestre F
Year: 2021
Journal: Sci Transl Med
Title: Alpelisib administration reduced lymphatic malformations in a mouse model and in patients.
Volume: 13
Issue: 614
Pages: eabg0809
•
•
•
•
•
Publication
34975329 | J:317484
First Author: Martinez JD
Year: 2022
Journal: Int J Biol Sci
Title: Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway.
Volume: 18
Issue: 1
Pages: 229-241
•
•
•
•
•
Publication
23633918 | J:199722
First Author: Squarize CH
Year: 2013
Journal: Neoplasia
Title: PTEN deficiency contributes to the development and progression of head and neck cancer.
Volume: 15
Issue: 5
Pages: 461-71
•
•
•
•
•
Publication
23593290 | J:200028
First Author: Deming DA
Year: 2013
Journal: PLoS One
Title: mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.
Volume: 8
Issue: 4
Pages: e60709
•
•
•
•
•
Publication
29320480 | J:257750
First Author: Sulli G
Year: 2018
Journal: Nature
Title: Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
Volume: 553
Issue: 7688
Pages: 351-355
•
•
•
•
•
Publication
19843858 | J:153952
First Author: Qian CN
Year: 2009
Journal: Cancer Res
Title: Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models.
Volume: 69
Issue: 21
Pages: 8256-64
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom