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Search results 201 to 293 out of 293 for Hook2

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0.037s
Type Details Score
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_06
Specimen Label: euxassay_002815_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_07
Specimen Label: euxassay_002815_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_08
Specimen Label: euxassay_002815_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_09
Specimen Label: euxassay_002815_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_10
Specimen Label: euxassay_002815_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_11
Specimen Label: euxassay_002815_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_12
Specimen Label: euxassay_002815_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_13
Specimen Label: euxassay_002815_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_14
Specimen Label: euxassay_002815_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_15
Specimen Label: euxassay_002815_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_16
Specimen Label: euxassay_002815_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_17
Specimen Label: euxassay_002815_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_18
Specimen Label: euxassay_002815_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_19
Specimen Label: euxassay_002815_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_20
Specimen Label: euxassay_002815_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1061666
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825407
Age: embryonic day 14.5
Image: euxassay_002815_21
Specimen Label: euxassay_002815_21
Detected: true
Specimen Num: 21
Publication    
First Author: Strausberg R
Year: 2002
Journal: GenBank Submission
Title: Mus musculus, clone MGC: 28586 IMAGE: 4211990, mRNA, complete cds
Pages: BC019486
Publication
First Author: Liu Y
Year: 2015
Journal: PLoS Genet
Title: LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.
Volume: 11
Issue: 3
Pages: e1005090
Publication
First Author: White RA
Year: 2009
Journal: Blood Cells Mol Dis
Title: Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan).
Volume: 43
Issue: 2
Pages: 141-8
Publication
First Author: Quesnel-Vallières M
Year: 2015
Journal: Genes Dev
Title: Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.
Volume: 29
Issue: 7
Pages: 746-59
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Szebenyi G
Year: 2007
Journal: Traffic
Title: Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.
Volume: 8
Issue: 1
Pages: 32-46
Protein
Organism: Mus musculus/domesticus
Length: 678  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1780  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 987  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
Publication
First Author: Gromley A
Year: 2003
Journal: J Cell Biol
Title: A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase.
Volume: 161
Issue: 3
Pages: 535-45
Publication
First Author: Gromley A
Year: 2005
Journal: Cell
Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.
Volume: 123
Issue: 1
Pages: 75-87
Protein Domain
Type: Family
Description: Centriolin (also known as CEP110) localises to the maternal centriole and functions in both cytokinesis and cell cycle progression []. During the late steps of cytokinesis, centriolin anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission []. Centriolin also interacts with Hook2 protein, which may function as adaptors to link various organelle cargos to dynein and may functions in centrosome positioning [].
Publication
First Author: Okuda H
Year: 2017
Journal: FASEB J
Title: LRGUK1 is part of a multiprotein complex required for manchette function and male fertility.
Volume: 31
Issue: 3
Pages: 1141-1152
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: true
Protein Domain
Type: Domain
Description: The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting []. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to Golgi membranes while both Hook1 and Hook2 are localised to discrete but unidentified cellular structures [, ]. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubule structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head []. They are a widely expressed class of dynein-associated cargo adaptor proteins which include different domains. The N-terminal partof these proteins is sufficient to form a stable complex with dynein-dynactin and includes the most conserved region within the first 160 amino acids, termed the Hook domain. This domain is followed by three coiled-coil domains, important for dimerization and activation of dynein-dynactin complex motility, and then a C-terminal domain that binds a variety of proteins specific for each Hook isoform, involved in binding to specific organelles (organelle-binding domains). All mammalian Hook isoforms form a complex with Fused Toes and the Fused Toes- and Hook-interacting protein; fungal homologues of these proteins are important for dynein-mediated early endosome transport by linking Hook to the cargo [].This entry represents the central coiled-coiled region and the divergent C-terminal domain from Hook proteins.
Publication
First Author: Walenta JH
Year: 2001
Journal: J Cell Biol
Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.
Volume: 152
Issue: 5
Pages: 923-34
Publication
First Author: Mendoza-Lujambio I
Year: 2002
Journal: Hum Mol Genet
Title: The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
Volume: 11
Issue: 14
Pages: 1647-58
Publication
First Author: Schroeder CM
Year: 2016
Journal: J Cell Biol
Title: Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
Volume: 214
Issue: 3
Pages: 309-18
Publication
First Author: Narayanan R
Year: 2000
Journal: J Neurobiol
Title: Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling.
Volume: 45
Issue: 2
Pages: 105-19
Publication
First Author: Marivin A
Year: 2019
Journal: J Cell Biol
Title: GPCR-independent activation of G proteins promotes apical cell constriction in vivo.
Volume: 218
Issue: 5
Pages: 1743-1763
Publication
First Author: Nechipurenko IV
Year: 2016
Journal: Dev Cell
Title: A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Volume: 38
Issue: 5
Pages: 493-506
Protein Domain
Type: Domain
Description: The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting []. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to Golgi membranes while both Hook1 and Hook2 are localised to discrete but unidentified cellular structures [, ]. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubule structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head []. They are a widely expressed class of dynein-associated cargo adaptor proteins which include different domains. The N-terminal part of these proteins is sufficient to form a stable complex with dynein-dynactin and includes the most conserved region within the first 160 amino acids, termed the Hook domain. This domain is followed by three coiled-coil domains, important for dimerization and activation of dynein-dynactin complex motility, and then a C-terminal domain that binds a variety of proteins specific for each Hook isoform, involved in binding to specific organelles (organelle-binding domains). All mammalian Hook isoforms form a complex with Fused Toes and the Fused Toes- and Hook-interacting protein; fungal homologues of these proteins are important for dynein-mediated early endosome transport by linking Hook to the cargo [].This entry includes residues in the first 160 amino acids at the N-terminal of Hook, which is the most conserved region and necessary for dynein-dynactin interaction. It interacts with dynein light intermediate chain 1 (LIC1) []. This domain is also found in protein Daple []and Girdin []which are G-protein modulators involved in ciliogenesis and cilium morphology, integrity of the actin cytoskeleton, formation of actin stress fibres and lamellipodia and membrane sorting in the early endosome.
Protein
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1481  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1481  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1873  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2009  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2016  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1427  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2334  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2333  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2333  
Fragment?: false