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Search results 501 to 592 out of 592 for Tbk1

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Type Details Score
Publication
First Author: Tan Y
Year: 2019
Journal: Cell
Title: Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.
Volume: 177
Issue: 2
Pages: 384-398.e11
Publication
First Author: An H
Year: 2006
Journal: Immunity
Title: SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.
Volume: 25
Issue: 6
Pages: 919-28
Publication
First Author: Fang R
Year: 2017
Journal: J Immunol
Title: NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
Volume: 199
Issue: 9
Pages: 3222-3233
Publication
First Author: Li F
Year: 2018
Journal: J Clin Invest
Title: HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Volume: 128
Issue: 9
Pages: 4148-4162
Publication
First Author: Cerboni S
Year: 2017
Journal: J Exp Med
Title: Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes.
Volume: 214
Issue: 6
Pages: 1769-1785
Publication
First Author: Dalet A
Year: 2017
Journal: EMBO J
Title: Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Volume: 36
Issue: 6
Pages: 761-782
Publication
First Author: Linares JF
Year: 2021
Journal: Mol Cell
Title: PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Volume: 81
Issue: 21
Pages: 4509-4526.e10
Publication
First Author: Zhang LJ
Year: 2016
Journal: Immunity
Title: Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury.
Volume: 45
Issue: 1
Pages: 119-30
Publication
First Author: Ye L
Year: 2019
Journal: PLoS Pathog
Title: USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Volume: 15
Issue: 4
Pages: e1007680
Publication
First Author: Enesa K
Year: 2012
Journal: J Biol Chem
Title: Pellino1 is required for interferon production by viral double-stranded RNA.
Volume: 287
Issue: 41
Pages: 34825-35
Publication
First Author: Lam AR
Year: 2014
Journal: Cancer Res
Title: RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.
Volume: 74
Issue: 8
Pages: 2193-2203
Publication
First Author: Shostak K
Year: 2014
Journal: Cell Death Differ
Title: MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Volume: 21
Issue: 5
Pages: 811-24
Publication
First Author: Zhang Z
Year: 2011
Journal: Nat Immunol
Title: The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
Volume: 12
Issue: 10
Pages: 959-65
Publication
First Author: Boyd CR
Year: 2009
Journal: J Immunol
Title: Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.
Volume: 183
Issue: 12
Pages: 7703-9
Publication
First Author: Tanaka H
Year: 2010
Journal: Arch Biochem Biophys
Title: The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice.
Volume: 498
Issue: 1
Pages: 35-42
Publication
First Author: Shen RR
Year: 2011
Journal: Oncogene
Title: Emerging roles for the non-canonical IKKs in cancer.
Volume: 30
Issue: 6
Pages: 631-41
Publication
First Author: Chen W
Year: 2016
Journal: PLoS Pathog
Title: ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Volume: 12
Issue: 2
Pages: e1005462
Publication  
First Author: Sun H
Year: 2017
Journal: Nat Commun
Title: USP13 negatively regulates antiviral responses by deubiquitinating STING.
Volume: 8
Pages: 15534
Publication
First Author: Gong K
Year: 2020
Journal: Nat Cancer
Title: EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer.
Volume: 1
Issue: 4
Pages: 394-409
Publication  
First Author: Liu Z
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.
Volume: 119
Issue: 1
Publication
First Author: Li S
Year: 2022
Journal: Nat Commun
Title: Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Volume: 13
Issue: 1
Pages: 105
Publication
First Author: Wang Y
Year: 2022
Journal: Cell Rep
Title: Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
Volume: 41
Issue: 1
Pages: 111434
Publication
First Author: Liu H
Year: 2022
Journal: Cell Rep
Title: Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis.
Volume: 41
Issue: 2
Pages: 111469
Publication
First Author: Snelling T
Year: 2022
Journal: Biochem J
Title: Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.
Volume: 479
Issue: 20
Pages: 2195-2216
Publication
First Author: Kuang M
Year: 2023
Journal: Sci Adv
Title: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Volume: 9
Issue: 33
Pages: eadg5211
Publication
First Author: Cao Y
Year: 2023
Journal: Cell Rep
Title: Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.
Volume: 42
Issue: 10
Pages: 113262
Publication
First Author: Mirza MU
Year: 2020
Journal: J Pharm Anal
Title: Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase.
Volume: 10
Issue: 4
Pages: 320-328
Publication  
First Author: Gurung AB
Year: 2020
Journal: Gene Rep
Title: In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors.
Volume: 21
Pages: 100860
Publication
First Author: Yuen CK
Year: 2020
Journal: Emerg Microbes Infect
Title: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
Volume: 9
Issue: 1
Pages: 1418-1428
Protein Domain
Type: Domain
Description: Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a vital role in catalysing the unwinding of duplex oligonucleotides into single strands in an NTP-dependent manner. It is a multidomain protein which includes an N-terminal Cys/His rich zinc-binding domain (ZBD), followed by a stalk and 1B domains, and a helicase core that belongs to the superfamily SF1 of helicases, containing two RecA1 and RecA2 domains [, ]. The stalk region connects the ZBD domain and 1B domain. Nsp13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domain form the triangular base, while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [, , ]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist. It is involved in type I interferon (IFN-I) response as it binds and blocks TBK1 phosphorylation to inhibit interferon regulatory factor 3 (IRF3) which results in decreased IRF3 activation [, ].This entry represents the 1B domain, which has a regulatory role modulating the nucleic acid substrate binding. Based on the structures from the related Equine arteritis virus (EAV) NSP10, it is likely that 1B domain forms a channel together with 1A and 2A domains that accommodates the single stranded nucleic acids [, ].
Publication
First Author: Saitoh T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
Volume: 106
Issue: 49
Pages: 20842-6
Publication
First Author: Minegishi Y
Year: 2013
Journal: Hum Mol Genet
Title: Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.
Volume: 22
Issue: 17
Pages: 3559-67
Publication
First Author: Oganesyan G
Year: 2006
Journal: Nature
Title: Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.
Volume: 439
Issue: 7073
Pages: 208-11
Publication
First Author: Häcker H
Year: 2006
Journal: Nature
Title: Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Volume: 439
Issue: 7073
Pages: 204-7
Publication
First Author: Takaoka A
Year: 2007
Journal: Nature
Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Volume: 448
Issue: 7152
Pages: 501-5
Publication
First Author: Paun A
Year: 2008
Journal: J Biol Chem
Title: Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response.
Volume: 283
Issue: 21
Pages: 14295-308
Publication
First Author: Sellier C
Year: 2016
Journal: EMBO J
Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
Volume: 35
Issue: 12
Pages: 1276-97
Publication
First Author: Gui X
Year: 2019
Journal: Nature
Title: Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Volume: 567
Issue: 7747
Pages: 262-266
Publication
First Author: Hoffpauir CT
Year: 2020
Journal: J Immunol
Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
Volume: 205
Issue: 1
Pages: 153-167
Publication
First Author: Dewi Pamungkas Putri D
Year: 2019
Journal: J Biol Chem
Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
Volume: 294
Issue: 21
Pages: 8412-8423
Publication  
First Author: Li L
Year: 2020
Journal: Mol Immunol
Title: SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection.
Volume: 125
Pages: 51-62
Publication
First Author: Jiang X
Year: 2015
Journal: Hypertension
Title: Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.
Volume: 66
Issue: 2
Pages: 356-67
Publication
First Author: Wang Z
Year: 2012
Journal: PLoS One
Title: SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.
Volume: 7
Issue: 2
Pages: e31809
Publication
First Author: Peschard P
Year: 2012
Journal: Curr Biol
Title: Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.
Volume: 22
Issue: 21
Pages: 2063-8
Publication
First Author: Okamoto T
Year: 2020
Journal: Cancer Res
Title: FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.
Volume: 80
Issue: 17
Pages: 3580-3592
Publication
First Author: Zhang X
Year: 2016
Journal: Cancer Res
Title: Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1.
Volume: 76
Issue: 9
Pages: 2824-35
Publication
First Author: He X
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology.
Volume: 117
Issue: 32
Pages: 19465-19474
Publication
First Author: Clark K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
Volume: 108
Issue: 41
Pages: 17093-8
Publication
First Author: Gratz N
Year: 2011
Journal: PLoS Pathog
Title: Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection.
Volume: 7
Issue: 5
Pages: e1001345
Publication
First Author: Oussa NA
Year: 2013
Journal: Biochem Biophys Res Commun
Title: TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells.
Volume: 432
Issue: 1
Pages: 129-34
Publication  
First Author: Markovinovic A
Year: 2018
Journal: Neuroscience
Title: Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses.
Volume: 388
Pages: 139-151
Publication
First Author: Sharma M
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
Volume: 117
Issue: 27
Pages: 15989-15999
Publication
First Author: Malik AU
Year: 2021
Journal: Biochem J
Title: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Volume: 478
Issue: 3
Pages: 553-578
Publication
First Author: Lai R
Year: 2017
Journal: J Immunol
Title: Raf Kinase Inhibitor Protein Preferentially Promotes TLR3-Triggered Signaling and Inflammation.
Volume: 198
Issue: 10
Pages: 4086-4095
Publication
First Author: Xiang W
Year: 2016
Journal: Sci Adv
Title: PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.
Volume: 2
Issue: 7
Pages: e1501889
Publication
First Author: Pfaller CK
Year: 2008
Journal: J Virol
Title: Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Volume: 82
Issue: 24
Pages: 12365-73
Publication
First Author: Yang K
Year: 2006
Journal: Mol Biol Cell
Title: Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.
Volume: 17
Issue: 3
Pages: 1461-71
Publication
First Author: Randall CM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus.
Volume: 111
Issue: 2
Pages: E265-72
Publication
First Author: Hsia HC
Year: 2017
Journal: J Biol Chem
Title: Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity.
Volume: 292
Issue: 13
Pages: 5405-5417
Publication
First Author: Motani K
Year: 2018
Journal: J Biol Chem
Title: Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Volume: 293
Issue: 20
Pages: 7717-7726
Publication
First Author: Yu YQ
Year: 2020
Journal: Sci Rep
Title: PGAM5-MAVS interaction regulates TBK1/ IRF3 dependent antiviral responses.
Volume: 10
Issue: 1
Pages: 8323
Publication      
First Author: Khalil J
Year: 2020
Journal: Mol Cell Biol
Title: The Non-structural Protein NSs of SFTSV Causes Cytokine Storm Through the Hyper-activation of NF-κB.
Publication
First Author: Liu X
Year: 2019
Journal: Cell Res
Title: Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling.
Volume: 29
Issue: 1
Pages: 42-53
Publication
First Author: Guo R
Year: 2023
Journal: ESC Heart Fail
Title: Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
Volume: 10
Issue: 4
Pages: 2338-2344
Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Publication
First Author: Dai P
Year: 2014
Journal: PLoS Pathog
Title: Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.
Volume: 10
Issue: 4
Pages: e1003989
Publication  
First Author: Morell M
Year: 2022
Journal: EBioMedicine
Title: SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model.
Volume: 76
Pages: 103808
Publication
First Author: Liang L
Year: 2022
Journal: PLoS Pathog
Title: cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner.
Volume: 18
Issue: 2
Pages: e1010233
Publication
First Author: Pascall JC
Year: 2018
Journal: PLoS One
Title: GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
Volume: 13
Issue: 5
Pages: e0196504
Publication
First Author: Mueller-Ortiz SL
Year: 2017
Journal: J Immunol
Title: The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway.
Volume: 198
Issue: 8
Pages: 3237-3244
Publication
First Author: Caignard G
Year: 2013
Journal: PLoS Pathog
Title: Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
Volume: 9
Issue: 9
Pages: e1003637
Publication
First Author: Majumdar T
Year: 2015
Journal: PLoS Pathog
Title: Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.
Volume: 11
Issue: 3
Pages: e1004779
Publication  
First Author: Jin X
Year: 2023
Journal: Front Immunol
Title: The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection.
Volume: 14
Pages: 1235590
Publication  
First Author: Manivanh R
Year: 2017
Journal: J Virol
Title: Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.
Volume: 91
Issue: 23
Publication
First Author: Chen J
Year: 2020
Journal: Cell
Title: Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
Volume: 182
Issue: 6
Pages: 1560-1573.e13
Publication
First Author: Jia Z
Year: 2019
Journal: Nucleic Acids Res
Title: Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Volume: 47
Issue: 12
Pages: 6538-6550
Publication
First Author: Hao W
Year: 2017
Journal: PLoS Pathog
Title: Crystal structure of Middle East respiratory syndrome coronavirus helicase.
Volume: 13
Issue: 6
Pages: e1006474
Publication
First Author: Xia H
Year: 2020
Journal: Cell Rep
Title: Evasion of Type I Interferon by SARS-CoV-2.
Volume: 33
Issue: 1
Pages: 108234
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Lubin JH
Year: 2022
Journal: Proteins
Title: Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic.
Volume: 90
Issue: 5
Pages: 1054-1080
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112