This family represents the PPP2R1A-PPP2R2A-interacting phosphatase regulators (PABIRs), also known as FAM122 which includes PABIR1, PABIR2 and PABIR3 family members (FAM122A, B and C, respectively). The most studied member is PABIR1/FAM122A, which was identified as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity [, ]. It potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) [].
