Type |
Details |
Score |
Publication |
First Author: |
Gustafsson N |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1. |
Volume: |
70 |
Issue: |
3 |
Pages: |
1265-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly. |
Volume: |
21 |
Issue: |
1 |
Pages: |
27-36 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry consists of RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1, also known as HOIL-1) and SHARPIN. Both are components of the E3 ligase complex LUBAC (linear ubiquitin chain assembly complex). LUBAC is composed of HOIP, RBCK1/HOIL-1, and SHARPIN. HOIP is the catalytic subunit and its E3 activity can be effectively activated by HOIL-1 or SHARPIN []. The LUBAC complex catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [, , ].RBCK1/HOIL-1 contains an ubiquitin-like (UBL) domain followed by a Npl4 zinc finger (NZF) domain and a RBR (RING-between-RING) domain in the C-terminal portion of the protein. RBCK1 is a RING-between-RING E3 ligase, and it has also been shown to act as a transcriptional activator []. SHARPIN also contains a UBL domain and a Ub-binding NZF domain, but lacks the RBR domain and has a additional N-terminal pleckstrin homology (PH) domain [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Teh CE |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis. |
Volume: |
7 |
|
Pages: |
13353 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelsall IR |
Year: |
2022 |
Journal: |
EMBO J |
Title: |
HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation. |
Volume: |
41 |
Issue: |
8 |
Pages: |
e109700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Etemadi N |
Year: |
2013 |
Journal: |
FEBS J |
Title: |
Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. |
Volume: |
280 |
Issue: |
21 |
Pages: |
5283-97 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
508
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|