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Search results 101 to 200 out of 310 for Cdt1

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Type Details Score
GXD Expression  
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823794
Age: embryonic day 14.5
Image: euxassay_002385_19
Specimen Label: euxassay_002385_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823794
Age: embryonic day 14.5
Image: euxassay_002385_20
Specimen Label: euxassay_002385_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823794
Age: embryonic day 14.5
Image: euxassay_002385_21
Specimen Label: euxassay_002385_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823794
Age: embryonic day 14.5
Image: euxassay_002385_22
Specimen Label: euxassay_002385_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823794
Age: embryonic day 14.5
Image: euxassay_002385_23
Specimen Label: euxassay_002385_23
Detected: true
Specimen Num: 23
GXD Expression    
Probe: MGI:4354232
Assay Type: RNA in situ
Annotation Date: 2023-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7522793
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Ohtsubo M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.
Volume: 105
Issue: 30
Pages: 10396-401
Publication
First Author: Mosammaparast N
Year: 2013
Journal: J Cell Biol
Title: The histone demethylase LSD1/KDM1A promotes the DNA damage response.
Volume: 203
Issue: 3
Pages: 457-70
Publication
First Author: Albino D
Year: 2011
Journal: Int J Dev Biol
Title: Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration.
Volume: 55
Issue: 1
Pages: 65-72
Publication
First Author: Cang Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: DDB1 is essential for genomic stability in developing epidermis.
Volume: 104
Issue: 8
Pages: 2733-7
Publication
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
Publication
First Author: Tane S
Year: 2014
Journal: J Biol Chem
Title: Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes.
Volume: 289
Issue: 26
Pages: 18033-44
Publication
First Author: Park JY
Year: 2016
Journal: Development
Title: The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.
Volume: 143
Issue: 1
Pages: 133-46
Publication  
First Author: Suzuki T
Year: 2019
Journal: Development
Title: Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
Volume: 146
Issue: 4
Publication
First Author: Ulmke PA
Year: 2021
Journal: Stem Cell Reports
Title: Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
Volume: 16
Issue: 4
Pages: 968-984
Publication
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Protein Domain
Type: Domain
Description: This entry represents the geminin-binding domain of the DNA replication factor CDT1 and related domains whose functions are not known [].
UniProt Feature
Begin: 1
Description: DNA replication factor Cdt1
Type: chain
End: 557
Publication
First Author: Aggarwal P
Year: 2007
Journal: Genes Dev
Title: Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.
Volume: 21
Issue: 22
Pages: 2908-22
Publication
First Author: Khayrutdinov BI
Year: 2009
Journal: Protein Sci
Title: Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.
Volume: 18
Issue: 11
Pages: 2252-64
Publication
First Author: Wei Z
Year: 2010
Journal: J Biol Chem
Title: Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
Volume: 285
Issue: 17
Pages: 12469-73
Interaction Experiment
Description: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.
Interaction Experiment
Description: Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.
Publication
First Author: Jee J
Year: 2010
Journal: J Biol Chem
Title: Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.
Volume: 285
Issue: 21
Pages: 15931-40
Publication
First Author: Chen S
Year: 2007
Journal: Genes Dev
Title: Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
Volume: 21
Issue: 22
Pages: 2897-907
DO Term
Publication
First Author: Nishitani H
Year: 2000
Journal: Nature
Title: The Cdt1 protein is required to license DNA for replication in fission yeast.
Volume: 404
Issue: 6778
Pages: 625-8
Publication
First Author: Yanow SK
Year: 2001
Journal: EMBO J
Title: Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
Volume: 20
Issue: 17
Pages: 4648-56
Publication
First Author: Higa LA
Year: 2003
Journal: Nat Cell Biol
Title: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.
Volume: 5
Issue: 11
Pages: 1008-15
Interaction Experiment
Description: Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.
Publication
First Author: Saxena S
Year: 2004
Journal: Mol Cell
Title: A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Volume: 15
Issue: 2
Pages: 245-58
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 18, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
GO Term
Protein Domain
Type: Family
Description: Multicilin (also known as Idas) is required for multiciliate cell differentiation in diverse tissues []. Idas coordinately promotes cell cycle exit, centriole assembly, and FoxJ1 expression []. It interacts with Geminin, which inhibits the DNA replication licensing factor Cdt1 and regulates cell proliferation and differentiation []. The Idas-Geminin heterodimer binds Cdt1 less strongly than Geminin-Geminin [].
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 18.1, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Reporter
Publication  
First Author: Chen Y
Year: 2019
Journal: J Surg Res
Title: Visualization of Hepatocellular Regeneration in Mice After Partial Hepatectomy.
Volume: 235
Pages: 494-500
Publication  
First Author: Anderson DA
Year: 2022
Journal: J Exp Med
Title: Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8.
Volume: 219
Issue: 2
Allele
Name: transgene insertion, Shinichi Aizawa
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Richard Mort
Allele Type: Targeted
Attribute String: Reporter
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard Mort
Allele Type: Targeted
Attribute String: Conditional ready, Reporter
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Zygosity: ht
Has Mutant Allele: true
Protein Domain
Type: Homologous_superfamily
Description: In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. This entry represents the C-terminal domain of Cdt1 which is the most conserved region of Cdt1, essential for licensing and directly interacts with the MCM2-7 complex []. This region contains a WHD (winged helix domain), a typical DNA recognition motif []. The winged-helix fold is conserved throughout several other licensing factors, suggesting that they evolved from a common ancestor. In mouse Cdt1, the main role of the WH motif is to interact with MCM2-7 rather than with the DNA, as other winged-helix domains.
Protein Domain
Type: Family
Description: Geminin inhibits DNA replication by preventing the recruitment of the MCM complex to form the pre-replication complex at the origin of replication []. Geminin is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle []. Geminin can also inhibit the DNA replication licensing factor Cdt1 and regulates cell proliferation and differentiation []. Besides forming homodimers, Geminin can also form heterodimers with its homologue, Idas (also known as Multicilin) []. The Idas-Geminin heterodimer binds Cdt1 less strongly than Geminin-Geminin [].
Protein Domain
Type: Domain
Description: In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. This entry represents the C-terminal domain of Cdt1 which is the most conserved region of Cdt1, essential for licensing and directly interacts with the MCM2-7 complex []. This region contains a WHD (winged helix domain), a typical DNA recognition motif []. The winged-helix fold is conserved throughout several other licensing factors, suggesting that they evolved from a common ancestor. In mouse Cdt1, the main role of the WH motif is to interact with MCM2-7 rather than with the DNA, as other winged-helix domains.
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Caillat C
Year: 2013
Journal: J Biol Chem
Title: The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.
Volume: 288
Issue: 44
Pages: 31624-34
Publication
First Author: Chakraborty S
Year: 2022
Journal: Cell Rep
Title: Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.
Volume: 40
Issue: 12
Pages: 111360
Publication
First Author: Kamemizu C
Year: 2019
Journal: Biol Reprod
Title: Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause†.
Volume: 100
Issue: 5
Pages: 1204-1214
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ian J Jackson
Allele Type: Targeted
Attribute String: Reporter
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ian J Jackson
Allele Type: Targeted
Attribute String: Reporter
Protein Domain
Type: Domain
Description: The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments []. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD [].
Publication
First Author: Ma XS
Year: 2016
Journal: Mol Biol Cell
Title: Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility.
Volume: 27
Issue: 5
Pages: 768-75
Publication
First Author: Geng Y
Year: 2007
Journal: Mol Cell
Title: Kinase-independent function of cyclin E.
Volume: 25
Issue: 1
Pages: 127-39
Publication
First Author: Aggarwal P
Year: 2010
Journal: Cancer Cell
Title: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Volume: 18
Issue: 4
Pages: 329-40
Publication
First Author: Muñoz S
Year: 2017
Journal: Cell Rep
Title: In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.
Volume: 19
Issue: 5
Pages: 928-938
Publication
First Author: McGarry TJ
Year: 1998
Journal: Cell
Title: Geminin, an inhibitor of DNA replication, is degraded during mitosis.
Volume: 93
Issue: 6
Pages: 1043-53
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
Publication
First Author: Stubbs JL
Year: 2012
Journal: Nat Cell Biol
Title: Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.
Volume: 14
Issue: 2
Pages: 140-7
Publication
First Author: Chavkin NW
Year: 2022
Journal: Nat Commun
Title: Endothelial cell cycle state determines propensity for arterial-venous fate.
Volume: 13
Issue: 1
Pages: 5891
Publication
First Author: Casey AE
Year: 2018
Journal: J Cell Biol
Title: Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
Volume: 217
Issue: 8
Pages: 2951-2974
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Publication      
First Author: Cañizares MA
Year: 2019
Journal: J Anat
Title: Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Pefani DE
Year: 2011
Journal: J Biol Chem
Title: Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.
Volume: 286
Issue: 26
Pages: 23234-46
Publication
First Author: Srinivasan SV
Year: 2007
Journal: J Biol Chem
Title: RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
Volume: 282
Issue: 33
Pages: 23867-77