Type |
Details |
Score |
Publication |
First Author: |
Endo Y |
Year: |
2010 |
Journal: |
J Innate Immun |
Title: |
Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway. |
Volume: |
2 |
Issue: |
1 |
Pages: |
33-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthijsen RA |
Year: |
2009 |
Journal: |
Circulation |
Title: |
Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. |
Volume: |
119 |
Issue: |
16 |
Pages: |
2188-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golovkina TV |
Year: |
1998 |
Journal: |
J Virol |
Title: |
A novel membrane protein is a mouse mammary tumor virus receptor. |
Volume: |
72 |
Issue: |
4 |
Pages: |
3066-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Epifano O |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. |
Volume: |
270 |
Issue: |
45 |
Pages: |
27254-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tenner AJ |
Year: |
1999 |
Journal: |
Curr Opin Immunol |
Title: |
Membrane receptors for soluble defense collagens. |
Volume: |
11 |
Issue: |
1 |
Pages: |
34-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Banda NK |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis. |
Volume: |
185 |
Issue: |
9 |
Pages: |
5598-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
White RA |
Year: |
1994 |
Journal: |
Mamm Genome |
Title: |
The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize to chromosomes 14 and 19. |
Volume: |
5 |
Issue: |
12 |
Pages: |
807-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wright A |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Mart1 is located on mouse chromosome 19 and is excluded as a candidate for ep and ru. |
Volume: |
8 |
Issue: |
5 |
Pages: |
377-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pisko J |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres. |
Volume: |
11 |
Issue: |
1 |
Pages: |
9228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfister S |
Year: |
2011 |
Journal: |
Int J Dev Biol |
Title: |
Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. |
Volume: |
55 |
Issue: |
1 |
Pages: |
45-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
mannose-binding lectin (protein C) 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
mannose-binding lectin (protein A) 1; targeted mutation 1.1, Gregory L Stahl |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirano M |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta. |
Volume: |
175 |
Issue: |
5 |
Pages: |
3177-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheriff S |
Year: |
1994 |
Journal: |
Nat Struct Biol |
Title: |
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil. |
Volume: |
1 |
Issue: |
11 |
Pages: |
789-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawasaki N |
Year: |
1989 |
Journal: |
J Biochem |
Title: |
A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity. |
Volume: |
106 |
Issue: |
3 |
Pages: |
483-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nauta AJ |
Year: |
2003 |
Journal: |
Eur J Immunol |
Title: |
Mannose-binding lectin engagement with late apoptotic and necrotic cells. |
Volume: |
33 |
Issue: |
10 |
Pages: |
2853-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita M |
Year: |
1992 |
Journal: |
J Exp Med |
Title: |
Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. |
Volume: |
176 |
Issue: |
6 |
Pages: |
1497-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji YH |
Year: |
1993 |
Journal: |
J Immunol |
Title: |
Activation of the C4 and C2 components of complement by a proteinase in serum bactericidal factor, Ra reactive factor. |
Volume: |
150 |
Issue: |
2 |
Pages: |
571-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Mannose-binding protein C (MBL2) is a calcium-dependent lectin involved in innate immune defence. It binds to oligosaccharides (mannose, fucose and N-acetylglucosamine) on the surface of micro-organisms and initiates complement activation of the lectin pathway []. It also binds to late apoptotic cells, enabling their uptake by macrophages []. MBL2 forms a homotrimer []which then binds to mannan-binding lectin-associated serine peptidases, leading to their activation and cleavage of complement components C2 and C4 to form the C3/C5 convertase [, ]. MBL2 expressed on the brush border epithelial cells of kidney-proximal tubules interacts with meprin precursors, preventing activation []. The tertiary structure of MBL2 has been solved, and the protein contains a collagen-like and a C-typelectin domain []. |
|
•
•
•
•
•
|
Allele |
Name: |
mannose-binding lectin (protein A) 1; targeted mutation 1, Kazue Takahashi |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi K |
Year: |
2002 |
Journal: |
Microbes Infect |
Title: |
Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. |
Volume: |
4 |
Issue: |
8 |
Pages: |
773-84 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mbl1/Mbl1 |
Background: |
involves: 129S4/SvJae * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mbl1/Mbl1 Mbl2/Mbl2 |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mbl1/Mbl1 Mbl2/Mbl2 |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fcna/Fcna Mbl1/Mbl1 Mbl2/Mbl2 |
Background: |
involves: 129S4/SvJae |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
doubleridge |
Allele Type: |
Transgenic |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Khor AHP |
Year: |
2024 |
Journal: |
Cancer Sci |
Title: |
Regulation of the innate immune response and gut microbiome by p53. |
Volume: |
115 |
Issue: |
1 |
Pages: |
184-196 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freudenberg J |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
Locus category based analysis of a large genome-wide association study of rheumatoid arthritis. |
Volume: |
19 |
Issue: |
19 |
Pages: |
3863-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. |
Volume: |
177 |
Issue: |
7 |
Pages: |
4727-34 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic, insertion, F2 hybrid |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic, deletion |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamska M |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. |
Volume: |
255 |
Issue: |
2 |
Pages: |
350-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matrisciano F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage. |
Volume: |
6 |
Issue: |
1 |
Pages: |
e16447 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sung EA |
Year: |
2023 |
Journal: |
Am J Pathol |
Title: |
Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury. |
Volume: |
193 |
Issue: |
9 |
Pages: |
1130-1142 |
|
•
•
•
•
•
|
Publication |
First Author: |
MacDonald BT |
Year: |
2007 |
Journal: |
Bone |
Title: |
Bone mass is inversely proportional to Dkk1 levels in mice. |
Volume: |
41 |
Issue: |
3 |
Pages: |
331-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
dblr/dblr |
Background: |
involves: C57BL/6J * SJL/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
244
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
244
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nimmerjahn F |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. |
Volume: |
104 |
Issue: |
20 |
Pages: |
8433-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chae WJ |
Year: |
2016 |
Journal: |
Immunity |
Title: |
The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. |
Volume: |
44 |
Issue: |
2 |
Pages: |
246-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamska M |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
En1 and Wnt7a interact with Dkk1 during limb development in the mouse. |
Volume: |
272 |
Issue: |
1 |
Pages: |
134-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bergren SK |
Year: |
2005 |
Journal: |
Mamm Genome |
Title: |
Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a. |
Volume: |
16 |
Issue: |
9 |
Pages: |
683-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chae WJ |
Year: |
2017 |
Journal: |
Immunology |
Title: |
Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T-cell-mediated autoimmune colitis. |
Volume: |
152 |
Issue: |
2 |
Pages: |
265-275 |
|
•
•
•
•
•
|