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Search results 401 to 500 out of 637 for Cbl

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein Domain
IPR024162 | Adaptor_Cbl
Type: Family
Description: Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins knownto date: Cbl, CblB, and CblC/Cbl3 []. Cbls function as ubiquitin E3 ligase proteins, accepting ubiquitin from specific E2 ubiquitin-conjugating enzymes and transferring it to substrates, promoting their degradation []or endocytosis [].
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Protein
A0A0U1RQ85
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Protein
A0A0X1KG61
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
A0A0U1RP47
Organism: Mus musculus/domesticus
Length: 895  
Fragment?: false
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Protein
Q2M4H7
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
B9EKI5
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: false
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Publication
20501843 | J:160916
First Author: Kales SC
Year: 2010
Journal: Cancer Res
Title: Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.
Volume: 70
Issue: 12
Pages: 4789-94
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Gene
108697772 | cblc.S
Type: gene
Organism: frog, African clawed
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Publication
14523545 | J:86427
First Author: Dikic I
Year: 2003
Journal: Cell Mol Life Sci
Title: Cbl signaling networks in the regulation of cell function.
Volume: 60
Issue: 9
Pages: 1805-27
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Publication
10092522 | -
First Author: Howlett CJ
Year: 1999
Journal: Biochem Biophys Res Commun
Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
Volume: 257
Issue: 1
Pages: 129-38
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Publication
12649282 | -
First Author: Duval M
Year: 2003
Journal: J Biol Chem
Title: Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.
Volume: 278
Issue: 22
Pages: 20091-7
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Publication
15001553 | -
First Author: Kobayashi S
Year: 2004
Journal: FASEB J
Title: The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).
Volume: 18
Issue: 7
Pages: 929-31
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Publication
19265199 | -
First Author: Sun J
Year: 2009
Journal: J Biol Chem
Title: The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.
Volume: 284
Issue: 17
Pages: 11039-47
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Protein
A0A0U1RNF1
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Gene
100361892 | Cbll1-ps1
Type: gene
Organism: rat
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Gene
394041 | cbll1
Type: gene
Organism: zebrafish
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Gene
556277 | cblb
Type: gene
Organism: zebrafish
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Gene
565383 | cblc
Type: gene
Organism: zebrafish
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Gene
448509 | cblb
Type: gene
Organism: frog, western clawed
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Gene
100170461 | cbll1
Type: gene
Organism: frog, western clawed
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Gene
100101300 | cbll1.L
Type: gene
Organism: frog, African clawed
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Gene
108705407 | cbl.S
Type: gene
Organism: frog, African clawed
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Gene
398194 | cbl.L
Type: gene
Organism: frog, African clawed
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Gene
431829 | cblb.S
Type: gene
Organism: frog, African clawed
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Gene
443854 | cblb.L
Type: gene
Organism: frog, African clawed
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Gene
734524 | cbll1.S
Type: gene
Organism: frog, African clawed
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Publication
22158968 | J:183644
First Author: Okur MN
Year: 2012
Journal: Mol Cell Biol
Title: Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
Volume: 32
Issue: 4
Pages: 817-25
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Publication
17897636 | J:126344
First Author: Zha Y
Year: 2007
Journal: Cell Immunol
Title: An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Volume: 247
Issue: 2
Pages: 95-102
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Publication
36206490 | J:333323
First Author: Chen H
Year: 2023
Journal: Blood
Title: PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Volume: 141
Issue: 3
Pages: 244-259
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Pathway
R-MMU-912631 | Regulation of signaling by CBL
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Publication
- | J:342817
     
First Author: Reis E Sousa C
Year: 2023
Journal: MGI Direct Data Submission
Title: SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.
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Publication
17620338 | -
First Author: Reddi AL
Year: 2007
Journal: J Biol Chem
Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
Volume: 282
Issue: 40
Pages: 29336-47
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Interaction Experiment
Jansen SM (2009)
Description: ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.
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Publication
10078535 | -
First Author: Meng W
Year: 1999
Journal: Nature
Title: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Volume: 398
Issue: 6722
Pages: 84-90
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Publication
18840649 | -
First Author: Langenick J
Year: 2008
Journal: J Cell Sci
Title: A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling.
Volume: 121
Issue: Pt 21
Pages: 3524-30
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Interaction Experiment
Lane HC (2006)
Description: Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.
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Publication
7782294 | -
First Author: Tanaka S
Year: 1995
Journal: J Biol Chem
Title: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
Volume: 270
Issue: 24
Pages: 14347-51
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Publication
19268472 | -
First Author: Ababou A
Year: 2009
Journal: J Mol Biol
Title: Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.
Volume: 387
Issue: 5
Pages: 1120-36
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Publication
20100865 | J:161729
First Author: Kim J
Year: 2010
Journal: Mol Cell Biol
Title: The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
Volume: 30
Issue: 7
Pages: 1582-92
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Publication
16798838 | -
First Author: Lane HC
Year: 2006
Journal: Int Immunol
Title: Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.
Volume: 18
Issue: 8
Pages: 1315-25
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Interaction Experiment
Bandi SR (2009)
Description: E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
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Interaction Experiment
Okur MN (2011)
Description: Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
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Interaction Experiment
Shao Y (2003)
Description: Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.
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Interaction Experiment
Scholz G (2000)
Description: Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
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Interaction Experiment
Hunter S (1999)
Description: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
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Interaction Experiment
Bruzzaniti A (2005)
Description: Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.
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Interaction Experiment
Adler CE (2000)
Description: Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development.
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Interaction Experiment
Kanagasundaram V (1996)
Description: Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages.
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Allele
Cbl<em2Smoc> | MGI:7288665
Name: Casitas B-lineage lymphoma; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
17010379 | -
First Author: Stec E
Year: 2006
Journal: J Mol Biol
Title: Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator.
Volume: 364
Issue: 3
Pages: 309-22
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Publication
9401024 | -
First Author: van der Ploeg JR
Year: 1997
Journal: J Bacteriol
Title: Involvement of CysB and Cbl regulatory proteins in expression of the tauABCD operon and other sulfate starvation-inducible genes in Escherichia coli.
Volume: 179
Issue: 24
Pages: 7671-8
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Publication
17353186 | -
First Author: Pakuts B
Year: 2007
Journal: J Biol Chem
Title: The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.
Volume: 282
Issue: 25
Pages: 17953-63
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Interaction Experiment
Miyake S (1999)
Description: Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.
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Interaction Experiment
Arron JR (2001)
Description: A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.
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Interaction Experiment
Meng F (1998)
Description: A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
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Interaction Experiment
Wang L (2013)
Description: Berberine Inhibits Proliferation and Down-Regulates Epidermal Growth Factor Receptor through Activation of Cbl in Colon Tumor Cells.
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Interaction Experiment
Dale BM (2009)
Description: Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.
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Strain
MGI:6354579 | C57BL/6J-Cbl<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cbl<em1Smoc> | MGI:7288664
Name: Casitas B-lineage lymphoma; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
10799548 | -
First Author: Scholz G
Year: 2000
Journal: J Biol Chem
Title: Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
Volume: 275
Issue: 19
Pages: 14615-23
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Publication
20221403 | -
First Author: Kedar VP
Year: 2010
Journal: PLoS One
Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.
Volume: 5
Issue: 3
Pages: e9588
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Publication
12935897 | -
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
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Publication
19734451 | -
First Author: Bandi SR
Year: 2009
Journal: Blood
Title: E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Volume: 114
Issue: 19
Pages: 4197-208
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Publication
19263517 | -
First Author: Jansen SM
Year: 2009
Journal: Cell Signal
Title: ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.
Volume: 21
Issue: 5
Pages: 810-8
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Publication
15872089 | -
First Author: Bruzzaniti A
Year: 2005
Journal: Mol Biol Cell
Title: Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.
Volume: 16
Issue: 7
Pages: 3301-13
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Publication
10967110 | -
First Author: Adler CE
Year: 2000
Journal: J Biol Chem
Title: Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development.
Volume: 275
Issue: 46
Pages: 36472-8
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Publication
8947469 | -
 
First Author: Kanagasundaram V
Year: 1996
Journal: Biochem J
Title: Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages.
Volume: 320 ( Pt 1)
Pages: 69-77
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Protein
Q80XL1
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Publication
15159412 | -
First Author: Kowanetz K
Year: 2004
Journal: J Biol Chem
Title: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Volume: 279
Issue: 31
Pages: 32786-95
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Publication
10347229 | -
First Author: Miyake S
Year: 1999
Journal: J Biol Chem
Title: Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.
Volume: 274
Issue: 23
Pages: 16619-28
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Publication
11406619 | -
First Author: Arron JR
Year: 2001
Journal: J Biol Chem
Title: A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.
Volume: 276
Issue: 32
Pages: 30011-7
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Interaction Experiment
Reddi AL (2007)
Description: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
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Interaction Experiment
Tezuka T (1996)
Description: Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling.
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Interaction Experiment
Schnyder T (2011)
Description: B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
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Allele
Cbl<tm1(CBL)Homy> | MGI:6473289
Name: Casitas B-lineage lymphoma; targeted mutation 1, Hiroaki Honda
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Null/knockout
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Protein
Q3TTA7
Organism: Mus musculus/domesticus
Length: 982  
Fragment?: false
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Publication
16537422 | -
First Author: Wuerges J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for mammalian vitamin B12 transport by transcobalamin.
Volume: 103
Issue: 12
Pages: 4386-91
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Publication
17274763 | -
First Author: Wuerges J
Year: 2007
Journal: Biochem J
Title: Structural study on ligand specificity of human vitamin B12 transporters.
Volume: 403
Issue: 3
Pages: 431-40
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Protein Domain
IPR002157 | Cbl-bd_prot
Type: Family
Description: Cobalamin (Cbl or vitamin B12) is only accessible through diet in mammals. Absorption, plasma transport and cellular uptake of Cbl in mammals involves three Cbl-transporting proteins, which are listed below in order of increasing Cbl-specificity:Haptocorrin (cobalophilin), which binds Cbl and Cbl-derivatives such as cobinamide; it may play a role in preventing the absorption of cobalamin analogues produced by bacteria.Transcobalamin (TC), which transport Cbl from blood to cells.Intrinsic factor (IF), which promotes Cbl absorption in the ileum by specific receptor-mediated endocytosis.The structure of TC reveals a two-domain structure, an N-terminal alpha(6)-alpha(6) barrel, and a smaller C-terminal domain []. Many interactions between Cbl and its binding site in the interface of the two domains are conserved among the other Cbl transporters. Specificity for Cbl between the different transporters may reside in a β-hairpin motif found in the smaller C-terminal domain [].
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Interaction Experiment
Standaert ML (2004)
Description: Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.
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Allele
Cbl<tm1Dejs> | MGI:3709884
Name: Casitas B-lineage lymphoma; targeted mutation 1, David E James
Allele Type: Targeted
Attribute String: Not Specified
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Strain
MGI:6146335 | B6;129P2-Cbl<tm1(CBL)Homy>/HomyRbrc
Attribute String: mutant stock, targeted mutation
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Publication
20354197 | -
First Author: Kudla J
Year: 2010
Journal: Plant Cell
Title: Calcium signals: the lead currency of plant information processing.
Volume: 22
Issue: 3
Pages: 541-63
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Publication
23335733 | -
First Author: Drerup MM
Year: 2013
Journal: Mol Plant
Title: The Calcineurin B-like calcium sensors CBL1 and CBL9 together with their interacting protein kinase CIPK26 regulate the Arabidopsis NADPH oxidase RBOHF.
Volume: 6
Issue: 2
Pages: 559-69
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Protein Domain
IPR045198 | CNBL1-10
Type: Family
Description: CBL proteins are calcium sensors that work with their interacting protein kinases (CIPKs) in the plant calcium signalling system []. In Arabidopsis there are 10 CBL Ca2+ sensors and 26 CIPK-type kinases encoded in the genome. Different combinations of CBL-CIPK proteins contribute to the complex network that connects various extracellular signals to defined cellular responses [, ].
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Publication
9722576 | -
First Author: Ito N
Year: 1998
Journal: J Biol Chem
Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
Volume: 273
Issue: 36
Pages: 23410-8
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Protein Coding Gene
MGI:96052 | Hck
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P08103
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Publication
15581361 | -
First Author: Standaert ML
Year: 2004
Journal: Biochemistry
Title: Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.
Volume: 43
Issue: 49
Pages: 15494-502
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Protein
P52787
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
O88968
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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