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Search results 101 to 109 out of 109 for Med4

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Type

Details

Score

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Protein

Q9CQA5

Organism:	Mus musculus/domesticus
Length:	270
Fragment?:	false

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Publication

10235266 | -

First Author:	Rachez C
Year:	1999
Journal:	Nature
Title:	Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.
Volume:	398
Issue:	6730
Pages:	824-8

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Publication

10235267 | -

First Author:	Näär AM
Year:	1999
Journal:	Nature
Title:	Composite co-activator ARC mediates chromatin-directed transcriptional activation.
Volume:	398
Issue:	6730
Pages:	828-32

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Protein Domain

IPR019258 | Mediator_Med4

Type:

Family

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Membersof this family represent the Med4 subunit of the Mediator (Med) complex [, ].

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DO Term

DOID:0070300 | multiple epiphyseal dysplasia 4

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Allele

Tg(Med4-EGFP)LD241Gsat | MGI:5311745

Name:	transgene insertion LD241, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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Strain

MGI:5313014 | STOCK Tg(Med4-EGFP)LD241Gsat/Mmucd

Attribute String:

transgenic, mutant stock

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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