This entry represents a conserved site found in some of the AB hydrolase 4 family members, including mammalian ABHD1/2/3, budding yeast Eht1, Eeb1 and MGL2, and bacterial putative esterases.Human ABHD3 is a phospholipase that may play a role in phospholipids remodeling. It may selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position []. Mouse ABHD2 may play a role in smooth muscle cells migration []. Yeast Eht1 and its paralogue, Eeb1, are Acyl-coenzymeA:ethanol O-acyltransferases involved in medium-chain fatty acid ethyl ester biosynthesis during fermentation []. MGL2 converts monoacylglycerides (MAG) to free fatty acids and glycerol, having preference for palmitoyl-MAG []. It does not seem to play an important role in medium-chain fatty acid ethyl ester formation []. MGL2 also possesses ester hydrolase and low but persistent TAG lipase activity [].
