Sodium channel and clathrin linker 1 (SCLT1/CAP-1A) is an adapter protein that links clathrin and sodium channel Na(v)1.8. It may regulate Na(v)1.8 channel density at the cell surface []. SCLT1 is a component of the distal appendages (DAPs) of centrioles, which are thought to anchor cilia to the plasma membrane []. SCLT1 mutations are associated with the ciliopathy known as oral-facial-digital syndrome (OFD) [, ].
Centriole distal appendages (DAPs) anchor cilia to the plasma membrane and are thought to initiate primary cilium assembly through ciliary vesicles docking to the mother centriole. Centrosomal protein of 83kDa (Cep83), previously known as coiled-coil domain-containing protein 41 or CCDC41, is a DAP component required for the docking of ciliary vesicles []. Cep38 has been shown to recruit SCLT1 and Cep89, also DAP components, to centrioles [].
