Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the MIT domain found in vacuolar protein sorting-associated protein 4. The molecular function of the MIT domain is unclear [].There are two mammalian VPS4 isoforms, VPS4A and VPS4B. They belong to the AAA ATPase family. VPS4A is a central regulator for early endosome trafficking [, ]. VSP4 interacts with the ESCRT complex, which directs multiple cellular membrane remodelling events, ranging from the biogenesis of multivesicular bodies and exosomes to the final membrane abscission stage of cytokinesis []. The viral budding via host ESCRT complex can also be regulated by VPS4 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka H |
Year: |
2002 |
Journal: |
Biochem J |
Title: |
Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. |
Volume: |
365 |
Issue: |
Pt 2 |
Pages: |
349-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cashikar AG |
Year: |
2014 |
Journal: |
Elife |
Title: |
Structure of cellular ESCRT-III spirals and their relationship to HIV budding. |
Volume: |
3 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hurley JH |
Year: |
2014 |
Journal: |
J Mol Biol |
Title: |
Making sense of Vps4. |
Volume: |
426 |
Issue: |
3 |
Pages: |
503-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Willén K |
Year: |
2017 |
Journal: |
Mol Neurodegener |
Title: |
Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A. |
Volume: |
12 |
Issue: |
1 |
Pages: |
61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ciccarelli FD |
Year: |
2003 |
Journal: |
Genomics |
Title: |
The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. |
Volume: |
81 |
Issue: |
4 |
Pages: |
437-41 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
444
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
437
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
444
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
444
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
437
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Scheuring S |
Year: |
1999 |
Journal: |
Gene |
Title: |
Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. |
Volume: |
234 |
Issue: |
1 |
Pages: |
149-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bishop N |
Year: |
2000 |
Journal: |
Mol Biol Cell |
Title: |
ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. |
Volume: |
11 |
Issue: |
1 |
Pages: |
227-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshimori T |
Year: |
2000 |
Journal: |
Mol Biol Cell |
Title: |
The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. |
Volume: |
11 |
Issue: |
2 |
Pages: |
747-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu A |
Year: |
2019 |
Journal: |
BMC Genet |
Title: |
Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia I. |
Volume: |
20 |
Issue: |
1 |
Pages: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3642215 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 9.5 |
Image: |
5I |
Note: |
Expression was enriched in the cranial neural crest cells (CCNC) of the trigeminal stream. Co-localization was observed with the CCNC marker, Sox10. |
Specimen Label: |
5I |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3642217 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 10.5 |
Image: |
6K |
Note: |
Expression was enriched in the cranial neural crest cells (CCNC) of the trigeminal stream. Co-localization was observed with the CCNC marker, Sox10. |
Specimen Label: |
6K |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647015 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 9.5 |
Image: |
5I |
Note: |
Expression was enriched in neuroepithelium. |
Specimen Label: |
5I |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647017 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 10.5 |
Image: |
6K |
Note: |
Expression was enriched in neuroepithelium. |
Specimen Label: |
6K |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185815 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 9.5 |
Image: |
5I |
Note: |
Expression was enriched in surface cephalic epithelium. |
Specimen Label: |
5I |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528937 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185817 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7529379 |
Age: |
embryonic day 10.5 |
Image: |
6K |
Note: |
Expression was enriched in surface cephalic epithelium. |
Specimen Label: |
6K |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujita H |
Year: |
2004 |
Journal: |
J Cell Sci |
Title: |
Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. |
Volume: |
117 |
Issue: |
Pt 14 |
Pages: |
2997-3009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Périer F |
Year: |
1994 |
Journal: |
FEBS Lett |
Title: |
Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast. |
Volume: |
351 |
Issue: |
2 |
Pages: |
286-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. |
Volume: |
8 |
|
Pages: |
16050 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohsaki Y |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. |
Volume: |
119 |
Issue: |
Pt 13 |
Pages: |
2643-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen D |
Year: |
2021 |
Journal: |
Genesis |
Title: |
VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis. |
Volume: |
59 |
Issue: |
4 |
Pages: |
e23415 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivastava U |
Year: |
2012 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. |
Volume: |
32 |
Issue: |
10 |
Pages: |
2380-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|