This entry includes histone transcription regulator 3 (Hir3) from fungi and calcineurin-binding protein 1 (CABIN1) from animals. Hir3 is part of the HIR complex, a nucleosome assembly complex that regulates histone gene transcription []. Human CABIN1 is a functional member of the HUCA (HIRA/UBN1/CABIN1/ASF1a) complex, which is a histone H3.3 chaperone complex involved in nucleosome assembly []and chromatin heterochromatinisation in senescent human cells [].
