Type |
Details |
Score |
Publication |
First Author: |
Oh SA |
Year: |
2005 |
Journal: |
Curr Biol |
Title: |
A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. |
Volume: |
15 |
Issue: |
23 |
Pages: |
2107-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh SA |
Year: |
2012 |
Journal: |
Plant J |
Title: |
Arabidopsis Fused kinase and the Kinesin-12 subfamily constitute a signalling module required for phragmoplast expansion. |
Volume: |
72 |
Issue: |
2 |
Pages: |
308-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang L |
Year: |
2008 |
Journal: |
Genes Dev |
Title: |
tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. |
Volume: |
22 |
Issue: |
16 |
Pages: |
2278-90 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of serine/threonine-protein kinases, including Fused from fruit flies, TIO from Arabidopsis, STK36 from animals and TsuA from Dictyostelium discoideum.In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage []. STK36 is involved in the Hedgehog signaling pathway []. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilisation of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI [, ]. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally []. In Dictyostelium discoideum, TsuA is required for polarisation and chemotaxis []. In plants, TIO is tightly localised to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. It plays a role in conventional modes of cytokinesis in meristems and during male gametogenesis and also acts in nonconventional modes of cytokinesis (cellularisation) during female gametogenesis [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Li ZJ |
Year: |
2012 |
Journal: |
Development |
Title: |
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. |
Volume: |
139 |
Issue: |
22 |
Pages: |
4152-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2024 |
Journal: |
Sci Signal |
Title: |
TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis. |
Volume: |
17 |
Issue: |
820 |
Pages: |
eabo0465 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos N |
Year: |
2014 |
Journal: |
J Cell Sci |
Title: |
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. |
Volume: |
127 |
Issue: |
Pt 7 |
Pages: |
1500-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee H |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation. |
Volume: |
480 |
Issue: |
4 |
Pages: |
574-579 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi Q |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. |
Volume: |
111 |
Issue: |
52 |
Pages: |
E5651-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han Y |
Year: |
2017 |
Journal: |
PLoS Biol |
Title: |
Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. |
Volume: |
15 |
Issue: |
8 |
Pages: |
e2002063 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wijaya J |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling. |
Volume: |
80 |
Issue: |
7 |
Pages: |
1524-1537 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiu C |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
Suppressor of fused-restrained Hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice. |
Volume: |
10 |
|
Pages: |
997838 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi K |
Year: |
2021 |
Journal: |
PLoS Genet |
Title: |
Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. |
Volume: |
17 |
Issue: |
7 |
Pages: |
e1009682 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang S |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth. |
Volume: |
12 |
Issue: |
17 |
Pages: |
7476-7490 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1048
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1316
|
Fragment?: |
false |
|
•
•
•
•
•
|