Cytokine-like protein 1 (CYTL1) was identified as a secretory protein expressed in CD34+ haemopoietic cells []. CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis [, ]. It may also work as a regulatory factor in embryo implantation []. This family of proteins, CYTL1, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.