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Search results 3301 to 3400 out of 4306 for Apc

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Type Details Score
Publication
9407054 | J:44868
First Author: Hanasaki K
Year: 1997
Journal: J Biol Chem
Title: Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice.
Volume: 272
Issue: 52
Pages: 32792-7
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Publication
10455175 | J:57024
First Author: Ishizaki J
Year: 1999
Journal: J Biol Chem
Title: Cloning and characterization of novel mouse and human secretory phospholipase A(2)s.
Volume: 274
Issue: 35
Pages: 24973-9
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Publication
17093080 | J:114918
First Author: Liu L
Year: 2006
Journal: J Neurosci
Title: M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.
Volume: 26
Issue: 45
Pages: 11588-98
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Allele
Pla2g2a<Mom1-s> | MGI:1857821
Name: phospholipase A2, group IIA (platelets, synovial fluid); modifier of Min1, tumor susceptibility
Allele Type: Spontaneous
Attribute String: Null/knockout
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Strain
MGI:5810122 | C.129X1-Pla2g2a<Mom1-s>/BlsJ
Attribute String: spontaneous mutation, mutant strain, congenic
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Publication
16272335 | J:119700
First Author: Piris-Gimenez A
Year: 2005
Journal: J Immunol
Title: In vivo protective role of human group IIa phospholipase A2 against experimental anthrax.
Volume: 175
Issue: 10
Pages: 6786-91
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Publication
12054745 | J:77028
First Author: Burton CA
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.
Volume: 294
Issue: 1
Pages: 88-94
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Publication
9516388 | J:83188
First Author: Wang TC
Year: 1998
Journal: Gastroenterology
Title: Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection.
Volume: 114
Issue: 4
Pages: 675-89
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Publication
- | J:54781
First Author: Deshpande C
Year: 1999
Journal: J Biosci
Title: Expression of enhancing factor/phospholipase A(2) in ICRC mice.
Volume: 24
Issue: 1
Pages: 21-26
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Publication
35076024 | J:343951
 
First Author: Miki Y
Year: 2022
Journal: JCI Insight
Title: Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.
Volume: 7
Issue: 2
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Protein Domain
IPR009234 | APC_basic_dom
Type: Domain
Description: This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules [].
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HT Experiment
E-GEOD-75996 | CFTR is a tumor suppressor gene in murine and human intestinal cancer [microarray]
Series Id: GSE75996
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
14701858 | J:251323
First Author: Wang H
Year: 2004
Journal: J Biol Chem
Title: Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup.
Volume: 279
Issue: 11
Pages: 10649-58
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Publication
12163563 | J:78417
First Author: Wong DA
Year: 2002
Journal: J Exp Med
Title: Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).
Volume: 196
Issue: 3
Pages: 349-57
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Publication
12438215 | J:80209
First Author: Engle SJ
Year: 2002
Journal: Cancer Res
Title: Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.
Volume: 62
Issue: 22
Pages: 6362-6
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Publication
9659576 | J:48995
First Author: Gould KA
Year: 1998
Journal: Exp Lung Res
Title: Analysis of the Mom1 modifier of intestinal neoplasia in mice.
Volume: 24
Issue: 4
Pages: 437-53
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Publication
10657948 | J:60619
First Author: Papanikolaou A
Year: 2000
Journal: Carcinogenesis
Title: Expression analysis of the group IIA secretory phospholipase A(2) in mice with differential susceptibility to azoxymethane-induced colon tumorigenesis.
Volume: 21
Issue: 2
Pages: 133-8
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Publication
22323457 | J:196743
First Author: Lachke SA
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: iSyTE: integrated Systems Tool for Eye gene discovery.
Volume: 53
Issue: 3
Pages: 1617-27
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Allele
Apc<em1Smoc> | MGI:7288286
Name: APC, WNT signaling pathway regulator; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Publication
10888670 | -
First Author: Leverson JD
Year: 2000
Journal: Mol Biol Cell
Title: The APC11 RING-H2 finger mediates E2-dependent ubiquitination.
Volume: 11
Issue: 7
Pages: 2315-25
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Publication
25306923 | -
First Author: Brown NG
Year: 2014
Journal: Mol Cell
Title: Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.
Volume: 56
Issue: 2
Pages: 246-260
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Protein Domain
IPR024991 | RING-H2_APC11
Type: Domain
Description: Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome (APC) []. The APC subunits are cullin family proteins with ubiquitin ligase activity []. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. Apc11 contains a canonical RING-H2-finger domain, which includes one histidine and seven cysteine residues that coordinate two Zn2+ ions. In addition, it contains a third Zn2+-binding site and the third Zn2+ ion is not essential for its ligase activity []. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability [].This entry represents the RING-H2 finger found in Apc11.
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Publication
20037474 | -
First Author: Xu Y
Year: 2010
Journal: Plant Signal Behav
Title: APC-targeted RAA1 degradation mediates the cell cycle and root development in plants.
Volume: 5
Issue: 3
Pages: 218-23
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Protein Domain
IPR024274 | APC9
Type: Family
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].All APC subunits are members of the cullin family proteins, which bind to a ring-finger subunit via a conserved cullin domain [].The APC can be divided in four parts, the third of which is a tetratricopeptide repeat arm (TPR) that contains multiple subunits, including Apc9 [].This entry represents Apc9, one of the subunits of the anaphase-promoting complex.
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Pseudogene
MGI:3646302 | Anapc15-ps
Type: pseudogene
Organism: mouse, laboratory
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HT Experiment
GSE77303 | Classical dendritic cells are required for dietary antigen-mediated peripheral regulatory T cell and tolerance induction I
Series Id: E-GEOD-77303
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
11514192 | -
First Author: Dikovskaya D
Year: 2001
Journal: Trends Cell Biol
Title: The adenomatous polyposis coli protein: in the limelight out at the edge.
Volume: 11
Issue: 9
Pages: 378-84
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Protein Domain
IPR009232 | EB1-bd
Type: Domain
Description: This region at the C terminus of the APC proteins binds the microtubule-associating protein EB-1 []. At the C terminus of the alignment is also a PDZ-binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins (e.g. ).
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Protein Domain
IPR009240 | APC_15aa_rpt
Type: Repeat
Description: The 15 aa repeat is found in the APC protein family. It is involved in binding beta-catenin []along with the repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.
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HT Experiment
E-GEOD-3915 | Transcription profiling of mouse PKCa -/- mutant vs. wild type small intestine
Series Id: GSE3915
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:6428175 | C57BL/6J-Apc<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
10358193 | J:335553
First Author: Laine VJ
Year: 1999
Journal: J Immunol
Title: Protection by group II phospholipase A2 against Staphylococcus aureus.
Volume: 162
Issue: 12
Pages: 7402-8
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Publication
20432503 | J:236850
First Author: Boilard E
Year: 2010
Journal: EMBO Mol Med
Title: A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.
Volume: 2
Issue: 5
Pages: 172-87
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Publication
15576846 | J:136941
First Author: Ghesquiere SA
Year: 2005
Journal: J Lipid Res
Title: Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.
Volume: 46
Issue: 2
Pages: 201-10
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Publication
8636402 | J:113573
First Author: Grass DS
Year: 1996
Journal: J Clin Invest
Title: Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.
Volume: 97
Issue: 10
Pages: 2233-41
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Publication
10603372 | J:130450
First Author: Laine VJ
Year: 2000
Journal: Infect Immun
Title: Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli infection.
Volume: 68
Issue: 1
Pages: 87-92
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Publication
10323781 | J:55442
First Author: Ivandic B
Year: 1999
Journal: Arterioscler Thromb Vasc Biol
Title: Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.
Volume: 19
Issue: 5
Pages: 1284-90
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Publication
26516211 | J:227851
First Author: Pataskar A
Year: 2016
Journal: EMBO J
Title: NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program.
Volume: 35
Issue: 1
Pages: 24-45
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GO Term
GO:1904667 | negative regulation of ubiquitin protein ligase activity
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Publication
10021369 | -
First Author: van Es JH
Year: 1999
Journal: Curr Biol
Title: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Volume: 9
Issue: 2
Pages: 105-8
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Publication
11691822 | -
First Author: Jarrett CR
Year: 2001
Journal: Cancer Res
Title: Human APC2 localization and allelic imbalance.
Volume: 61
Issue: 21
Pages: 7978-84
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Publication
10766743 | -
First Author: Hoier EF
Year: 2000
Journal: Genes Dev
Title: The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression.
Volume: 14
Issue: 7
Pages: 874-86
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Protein Domain
IPR026818 | Apc_fam
Type: Family
Description: Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces thedegradation of oncogenic beta-catenin and negatively regulates Wnt signalling []. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [, ]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [, ]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex []. It is requiredfor the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation []. APC mutations are particularly prevalent in colorectal cancer [].The adenomatous polyposis coli protein family also includes APC2 [, ]and APC-related protein 1 [].
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Protein
Q9CR23
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: false
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Protein
Q9JJR8
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
Q3UI08
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
A2AI11
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
D3YU78
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
D3Z6W5
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: false
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Publication
18541524 | -
First Author: Dodeller F
Year: 2008
Journal: J Biol Chem
Title: The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways.
Volume: 283
Issue: 31
Pages: 21487-94
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Publication
30962393 | -
 
Year: 2019
Journal: Plant Cell
Title: CORRECTION.
Volume: 31
Issue: 6
Pages: 1386-1387
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Protein Domain
IPR014786 | APC2_C
Type: Domain
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].This entry represents a domain found in the C terminus of APC subunit 2.
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Protein Domain
IPR044554 | APC2-like
Type: Family
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].This entry represents APC subunit 2, which is a distant member of the cullin protein family that functions as a scaffold in SCF assembly [].
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Protein Domain
IPR008853 | TMEM9/TMEM9B
Type: Family
Description: This entry includes human TMEM9/TMEM9B and their homologues. TMEM9 is a transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking []. It acts as a Wnt signaling amplifier that hyperactivates Wnt signaling for liver regeneration and tumorigenesis via lysosomal degradation of APC []. TMEM9B has been shown to regulate the activity of inflammatory signaling pathways [].
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Allele
Ifi208<Tg(Cspg4-cre)1Akik> | MGI:3778062
Name: interferon activated gene 208; transgene insertion 1, Akiko Nishiyama
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
12049731 | -
First Author: Peters JM
Year: 2002
Journal: Mol Cell
Title: The anaphase-promoting complex: proteolysis in mitosis and beyond.
Volume: 9
Issue: 5
Pages: 931-43
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Publication
22000517 | -
First Author: Morishita EC
Year: 2011
Journal: Structure
Title: Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.
Volume: 19
Issue: 10
Pages: 1496-508
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Protein Domain
IPR024790 | APC4_long_dom
Type: Domain
Description: Apc4 is one of the larger of the subunits of the anaphase-promoting complex (APC) or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation ofchromosomes and exit from mitosis in eukaryotes [, ]. Results in Caenorhabditis elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. The APC is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism [].This entry represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits.
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Protein Domain
IPR032335 | Sam68-YY
Type: Domain
Description: This entry represents a tyrosine-rich domain found in Sam68, also known as KH domain-containing, RNA-binding, signal transduction-associated protein. Sam68 regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with this domain to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumour-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes [].
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Publication
35915179 | J:335582
First Author: Yuan W
Year: 2022
Journal: Nat Neurosci
Title: Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex.
Volume: 25
Issue: 8
Pages: 1049-1058
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HT Experiment
E-GEOD-9287 | Differential gene expression in wild-type versus Yaa mutant mouse spleen cells
Series Id: GSE9287
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
D3YYQ9
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
D3Z3K9
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
W6CPJ9
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
D3Z344
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Strain
MGI:3797504 | B6;FVB-Ifi208<Tg(Cspg4-cre)1Akik>/J
Attribute String: mutant stock, transgenic
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Publication
25821912 | J:222422
First Author: Zonouzi M
Year: 2015
Journal: Nat Neurosci
Title: GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.
Volume: 18
Issue: 5
Pages: 674-82
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Genotype
Genotype
Symbol: Ifi208/Ifi208<+>
Background: involves: C57BL/6 * SJL
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGI:1289325 | Anapc16
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3644472 | Cdc20b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922680 | Anapc15
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916249 | Anapc10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916260 | Anapc13
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16896351 | -
First Author: Peters JM
Year: 2006
Journal: Nat Rev Mol Cell Biol
Title: The anaphase promoting complex/cyclosome: a machine designed to destroy.
Volume: 7
Issue: 9
Pages: 644-56
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Protein
D3Z392
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: false
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Publication
9387238 | -
 
First Author: Bigi F
Year: 1997
Journal: Microbiology
Title: A novel 27 kDa lipoprotein antigen from Mycobacterium bovis.
Volume: 143 ( Pt 11)
Pages: 3599-605
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Publication
14998516 | -
First Author: Bigi F
Year: 2004
Journal: Microbes Infect
Title: The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis.
Volume: 6
Issue: 2
Pages: 182-7
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Publication
15294983 | -
First Author: Gehring AJ
Year: 2004
Journal: J Immunol
Title: Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Volume: 173
Issue: 4
Pages: 2660-8
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Publication
12581360 | -
First Author: Steyn AJ
Year: 2003
Journal: Mol Microbiol
Title: Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.
Volume: 47
Issue: 4
Pages: 1075-89
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Publication
19584054 | -
First Author: Ors A
Year: 2009
Journal: J Biol Chem
Title: The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast.
Volume: 284
Issue: 36
Pages: 23989-94
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Protein Domain
IPR026000 | Apc5_dom
Type: Domain
Description: This entry represents a domain found in Apc5 (anaphase-promoting complex subunit 5).Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multisubunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Tetratricopeptide repeat protein 19 is a mitochondrial protein required for formation of the mitochondrial complex III [].Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [, ]. The N terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC []. This region of the Apc5 member proteins carries a TPR-like motif.
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Protein Domain
IPR016901 | APC10/Doc1
Type: Family
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].One of the subunits of the APC that is required for its ubiquitination activity is Doc1/Apc10, a protein composed of a Doc1 homology domain that has been identified in a number of diverse putative E3 ubiquitin ligases []. The Doc1 homology domain forms a β-sandwich structure that is related in architecture to the galactose-binding domain of galactose oxidase, the coagulation factor C2 domain and a domain of XRCC1. This group represents a subgroup of subunit 10.
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Protein Domain
IPR009830 | LppX/LprAFG
Type: Family
Description: This entry consists of several lipoproteins mainly from Mycobacterium species, collectively known as the LppX/LprAFG family. Proteins in this entry include:LprG () from Mycobacterium tuberculosis: an immunogenic 27kDa membrane-associated lipoprotein []. Expression of the LprG protein is essential for the growth of M. tuberculosis in immunocompetent mice []. Purification of LprG showed that it inhibits MHC-II antigen processing in primary human macrophages, providing a mechanism to avoid the host MHC-II-restricted CD4+ T cell response which is considered essential for control of M. tuberculosis infection []. LppX: a lipoprotein required for the translocation of complex lipids to the outer membrane of Mycobacterium tuberculosis. Its structure consists of a U-shaped β-half-barrel with a large hydrophobic cavity []. LprF: a membrane lipoprotein involved in the kdp signal transduction pathway, thought to be the primary response to osmotic stress [].lprA: a lipoprotein agonist of TLR2 that regulates innate immunity and APC function [].
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Publication
11884135 | -
First Author: Au SW
Year: 2002
Journal: J Mol Biol
Title: Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Volume: 316
Issue: 4
Pages: 955-68
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Publication
18485873 | -
First Author: Jin L
Year: 2008
Journal: Cell
Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.
Volume: 133
Issue: 4
Pages: 653-65
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Publication
14656967 | J:86796
First Author: Xie T
Year: 2003
Journal: Genome Res
Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.
Volume: 13
Issue: 12
Pages: 2621-36
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Protein Coding Gene
MGI:103097 | Anapc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913690 | Cdc26
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31879367 | J:291825
 
First Author: Morrison VE
Year: 2020
Journal: eNeuro
Title: Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum.
Volume: 7
Issue: 1
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Publication
29382710 | J:258147
First Author: Zuo H
Year: 2018
Journal: J Neurosci
Title: Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion.
Volume: 38
Issue: 9
Pages: 2359-2371
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Publication
33574458 | J:305652
First Author: Boshans LL
Year: 2021
Journal: Sci Rep
Title: Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Volume: 11
Issue: 1
Pages: 3552
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Publication
25568100 | J:218900
First Author: Bischof M
Year: 2015
Journal: J Neurosci
Title: Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.
Volume: 35
Issue: 1
Pages: 21-35
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Publication
24005306 | J:201745
First Author: Hill RA
Year: 2013
Journal: J Neurosci
Title: NG2 cells in white matter but not gray matter proliferate in response to PDGF.
Volume: 33
Issue: 36
Pages: 14558-66
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Ifi208/Ifi208<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+>
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein
Q8K2H6
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
C6EQJ2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Publication
12952940 | J:85368
First Author: Topol L
Year: 2003
Journal: J Cell Biol
Title: Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.
Volume: 162
Issue: 5
Pages: 899-908
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Publication
28537251 | J:246061
 
First Author: Yao Y
Year: 2017
Journal: Nat Commun
Title: Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.
Volume: 8
Pages: 15402
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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