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Search results 201 to 300 out of 379 for Cd27

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Type Details Score
Allele
Name: CD27 antigen; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
GO Term
Allele
Name: CD27 antigen; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: CD27 antigen; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
GO Term
Publication
First Author: Loenen WA
Year: 1992
Journal: J Immunol
Title: Genomic organization and chromosomal localization of the human CD27 gene.
Volume: 149
Issue: 12
Pages: 3937-43
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: CD27 antigen; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Burchill MA
Year: 2015
Journal: Eur J Immunol
Title: T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.
Volume: 45
Issue: 11
Pages: 3140-9
Publication
First Author: Heckel F
Year: 2022
Journal: Commun Biol
Title: Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.
Volume: 5
Issue: 1
Pages: 229
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Publication
First Author: He LZ
Year: 2013
Journal: J Immunol
Title: Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice.
Volume: 191
Issue: 8
Pages: 4174-83
Publication
First Author: Goodwin RG
Year: 1993
Journal: Cell
Title: Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.
Volume: 73
Issue: 3
Pages: 447-56
Allele    
Name: CD27 antigen; wild type
Publication
First Author: Hayakawa Y
Year: 2011
Journal: Cancer Sci
Title: Early activation and interferon-γ production of tumor-infiltrating mature CD27 high natural killer cells.
Volume: 102
Issue: 11
Pages: 1967-71
Allele
Name: CD27 antigen; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: CD27 antigen; targeted mutation 1, Jannie Borst
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: CD27 antigen; targeted mutation 1.1, Isabel Vogel
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: CD27 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: CD27 antigen; targeted mutation 1, GemPharmatech
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele  
Name: CD27 antigen; gene trap OST33464, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: CD27 antigen; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Kamazani FM
Year: 2013
Journal: Med Oncol
Title: CD44 and CD27 expression pattern in B cell precursor acute lymphoblastic leukemia and its clinical significance.
Volume: 30
Issue: 1
Pages: 359
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
Interaction Experiment
Description: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
Interaction Experiment
Description: Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK.
Allele
Name: CD27 antigen; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: Not specified
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: CD27 antigen; endonuclease-mediated mutation 6, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: CD27 antigen; endonuclease-mediated mutation 1, Institute of Molecular Genetics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: CD27 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence
Genotype
Symbol: Cd27/Cd27
Background: either: B6.129P2-CD27 or 129P2/OlaHsd-Tnfrsf7
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd27/Cd27
Background: B6.129P2-Cd27
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Cd27/Cd27
Background: C57BL/6NCrl-Cd27/Ccpcz
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Loenen WA
Year: 1998
Journal: Semin Immunol
Title: CD27 and (TNFR) relatives in the immune system: their role in health and disease.
Volume: 10
Issue: 6
Pages: 417-22
Publication
First Author: Satpathy S
Year: 2010
Journal: J Immunol
Title: Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK.
Volume: 185
Issue: 11
Pages: 6499-507
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Genotype
Symbol: Cd27/Cd27 Tg(CD19-Tnfsf7)#Rvl/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Prasad KV
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
Volume: 94
Issue: 12
Pages: 6346-51
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Xue L
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.
Volume: 99
Issue: 10
Pages: 6925-30
Publication
First Author: Jacquot S
Year: 2000
Journal: Immunol Res
Title: CD27/CD70 interactions regulate T dependent B cell differentiation.
Volume: 21
Issue: 1
Pages: 23-30
Protein Domain
Type: Family
Description: CD70 is a ligand of CD27 and is a TNF related transmembrane protein induced upon activation on T and B cells []. The CD27/CD70 interaction plays a key role in T dependent B cell responses and is responsible for plasma cell differentiation []. The CD27/CD70 pathway has been shown to contribute to the pathophysiology of autoimmunity [].
Publication
First Author: Han BK
Year: 2016
Journal: Semin Arthritis Rheum
Title: The CD27-CD70 pathway and pathogenesis of autoimmune disease.
Volume: 45
Issue: 4
Pages: 496-501
Publication
First Author: Denoeud J
Year: 2011
Journal: J Leukoc Biol
Title: Role of CD27/CD70 pathway of activation in immunity and tolerance.
Volume: 89
Issue: 2
Pages: 195-203
Protein Domain
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27, T14, S152, Tp55, S152 or LPFS2, has a key role in the generation of immunological memory via effects on T-cell expansion and survival, and B cell development [, ]. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. CD27 transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK, and mediates the signaling process through adaptor proteins TRAF2 and TRAF5. CD27-binding protein (SIVA), a pro-apoptotic protein, can bind to CD27 and may play an important role in the apoptosis induced by this receptor []. The potential role of the CD27/CD70 pathway in the course of inflammatory diseases, such as arthritis, and inflammatory bowel disease, suggests that CD70 may be a target for immune intervention. The expression of CD27 and CD44 molecules correlates with the differentiation stage of B cell precursors and has been shown to have a biological significance in acute lymphoblastic leukemia [].This entry represents the N-terminal domain of TNFRSF7. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
Protein
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
Protein Domain
Type: Family
Description: Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway []. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Henke A
Year: 2001
Journal: Virology
Title: The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.
Volume: 289
Issue: 1
Pages: 15-22
Publication
First Author: Li N
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Volume: 108
Issue: 31
Pages: 12851-6
GXD Expression      
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354920
Age: embryonic day 14.5
Specimen Label: Table S5 - Siva
Detected: false
Specimen Num: 1
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366716
Note: kidney
Specimen Label: HMGU_1366716
Detected: true
Specimen Num: 7
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692931
Note: kidney
Specimen Label: HMGU_692931
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366710
Specimen Label: HMGU_1366710
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692919
Specimen Label: HMGU_692919
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354920
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Siva
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2023-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7526629
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1868128
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692925
Note: vas deferens
Specimen Label: HMGU_692925
Detected: false
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366714
Specimen Label: HMGU_1366714
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692927
Specimen Label: HMGU_692927
Detected: true
Specimen Num: 15
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692917
Specimen Label: HMGU_692917
Detected: true
Specimen Num: 10
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366711
Specimen Label: HMGU_1366711
Detected: false
Specimen Num: 2
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692925
Specimen Label: HMGU_692925
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354920
Age: embryonic day 14.5
Specimen Label: Table S5 - Siva
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1510754
Assay Type: RNA in situ
Annotation Date: 2023-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7526629
Age: embryonic day 14.5
Note: Ventricular zone expression was greater than in the cortical plate.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366712
Specimen Label: HMGU_1366712
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692921
Specimen Label: HMGU_692921
Detected: true
Specimen Num: 12
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366717
Specimen Label: HMGU_1366717
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692933
Specimen Label: HMGU_692933
Detected: true
Specimen Num: 18
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_692915
Specimen Label: HMGU_692915
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691526
Age: postnatal adult
Image: HMGU_1366715
Specimen Label: HMGU_1366715
Detected: true
Specimen Num: 6