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Search results 101 to 200 out of 206 for Ggct

0.046s
Type Details Score
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310200
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423524
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EH63; Specimen C1860
Detected: false
Specimen Num: 1
Publication  
First Author: Harris MJ
Year: 1988
Journal: Mouse News Lett
Title: Ggc, Ldr-1 SDP.
Volume: 80
Pages: 151-52
Publication
First Author: Tulchin N
Year: 1981
Journal: Genetics
Title: gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2.
Volume: 99
Issue: 1
Pages: 109-16
Publication
First Author: Rubin MR
Year: 1987
Journal: Mol Cell Biol
Title: Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
Volume: 7
Issue: 10
Pages: 3836-41
Publication
First Author: Dush MK
Year: 1992
Journal: Dev Biol
Title: Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak.
Volume: 151
Issue: 1
Pages: 273-87
Publication
First Author: Chipman SD
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta.
Volume: 90
Issue: 5
Pages: 1701-5
Publication
First Author: Traina VL
Year: 1981
Journal: J Virol
Title: Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution.
Volume: 40
Issue: 3
Pages: 735-44
Publication
First Author: Fowler KJ
Year: 1993
Journal: Genomics
Title: Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6.
Volume: 16
Issue: 3
Pages: 782-4
Publication
First Author: Lueders KK
Year: 1995
Journal: Electrophoresis
Title: Multilocus genomic mapping with intracisternal A-particle proviral oligonucleotide probes hybridized to mouse DNA in dried agarose gels.
Volume: 16
Issue: 2
Pages: 179-85
Publication  
First Author: Bejarano E
Year: 2023
Journal: Redox Biol
Title: Unbalanced redox status network as an early pathological event in congenital cataracts.
Volume: 66
Pages: 102869
Publication  
First Author: Davisson MT
Year: 1989
Journal: Mouse News Lett
Title: Additional isoenzyme typing for selected inbred strains.
Volume: 84
Pages: 92-3
Publication
First Author: Heine D
Year: 1996
Journal: Mamm Genome
Title: Effect of the mouse scid mutation on meiotic recombination.
Volume: 7
Issue: 7
Pages: 497-500
Publication
First Author: Bućan M
Year: 1986
Journal: EMBO J
Title: Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.
Volume: 5
Issue: 11
Pages: 2899-905
Publication
First Author: Johnson KR
Year: 1992
Journal: Genomics
Title: Chromosomal localization of the murine gene and two related sequences encoding high-mobility-group I and Y proteins.
Volume: 12
Issue: 3
Pages: 503-9
Publication
First Author: Nadeau JH
Year: 1992
Journal: Mamm Genome
Title: Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence.
Volume: 3
Issue: 2
Pages: 55-64
Publication
First Author: Ramagli LS
Year: 1990
Journal: Biochem Genet
Title: Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis.
Volume: 28
Issue: 3-4
Pages: 123-36
Publication
First Author: Lueders KK
Year: 1995
Journal: Mouse Genome
Title: Mapping of mouse intracisternal A-particle proviral markers in the BXH RI series.
Volume: 93
Issue: 1
Pages: 161-163
Publication  
First Author: Nesbitt M
Year: 1990
Journal: Mouse Genome
Title: Strain distribution pattern of thirteen genetic loci in the AXB and BXA recombinant inbred set
Volume: 88
Pages: 113
Publication
First Author: Fowler KJ
Year: 1998
Journal: Cytogenet Cell Genet
Title: Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes.
Volume: 82
Issue: 1-2
Pages: 67-70
Publication
First Author: Bronson RT
Year: 1998
Journal: Am J Med Genet
Title: Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9.
Volume: 77
Issue: 4
Pages: 289-97
Publication
First Author: Johnson KR
Year: 1994
Journal: Mamm Genome
Title: Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.
Volume: 5
Issue: 11
Pages: 670-87
Publication      
First Author: Elliott R
Year: 2000
Journal: Personal Communication
Title: Chromosome Locations Based on RH mapping
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Gardiner DM
Year: 2005
Journal: FEMS Microbiol Lett
Title: Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus.
Volume: 248
Issue: 2
Pages: 241-8
Publication
First Author: Forseth RR
Year: 2011
Journal: J Am Chem Soc
Title: Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.
Volume: 133
Issue: 25
Pages: 9678-81
Publication  
First Author: Wang Y
Year: 2017
Journal: Fungal Genet Biol
Title: Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana.
Volume: 103
Pages: 25-33
Publication
First Author: Chankhamjon P
Year: 2014
Journal: Angew Chem Int Ed Engl
Title: Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion.
Volume: 53
Issue: 49
Pages: 13409-13
Protein Domain
Type: Family
Description: This entry contains the human protein C7orf24 () which has been used as a cancer marker with a potential role in cell proliferation. It has been characterised as gamma-glutamyl cyclotransferase (GGCT), a homodimer of two 21kDa subunits, that catalyses the formation of 5-oxoproline (2-pyrrolidone-5-carboxylic acid, pyroglutamic acid) from gamma-glutamyl dipeptides () []. L-gamma-glutamyl-L-amino acid ->5-oxoproline + L-amino acidThe structure of GGCT has been solved. Its topology is unrelated to other enzymes associated with cyclotransferase-like activity and its structure has been termed the GGCT-fold, which appears to be related to the BtrG-like superfamily. A potential active site pocket contains a highly conserved glutamic acid (Glu(98)), which when converted to either Ala or Gln completely inactivates the enzyme without altering the overall fold [].This entry also includes GGCT gliK, GGCT aclK and GGCT verK from fungi. GGCT gliK is part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterised by a disulfide bridged cyclic dipeptide [, ]. GGCT aclK mediates the biosynthesis of aspirochlorine []. GGCT verK mediates the biosynthesis of 11'-deoxyverticillin A, one of the dimeric epipolythiodioxopiperazines (ETPs) from the verticillin family that act as mycotoxins [].
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
Publication
First Author: Klock HE
Year: 2005
Journal: Proteins
Title: Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold.
Volume: 61
Issue: 4
Pages: 1132-6
Protein Domain
Type: Homologous_superfamily
Description: Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24 []. The enzyme participates in the gamma-glutamyl cycle, which plays a pre-eminent role in glutathione homoeostasis []. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism.Structurally, GGCT is comprised of 7 beta strands and 2 alpha helices, and it folds into a five-stranded, antiparallel β-barrel [].
Protein Domain
Type: Domain
Description: This entry represents a domain found in a group of gamma-glutamyl cyclotransferases (GGCTs), including AIG2 from Arabidopsis. GGCT is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline [, , ].AIG2 is an Arabidopsis protein that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 []. Its structure consists of a five-stranded β-barrel surrounded by two α-helices and a small β-sheet. A long flexible α-helix protrudes from the structure at the C-terminal end. Conserved residues in a hydrophilic cavity, which are able to bind small ligands, may act as an active site in AIG2-like proteins [].
Publication  
First Author: Kautzman AG
Year: 2018
Journal: Front Neurosci
Title: Genetic Control of Rod Bipolar Cell Number in the Mouse Retina.
Volume: 12
Pages: 285
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
Publication
First Author: Oakley AJ
Year: 2010
Journal: J Biol Chem
Title: Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.
Volume: 285
Issue: 13
Pages: 9642-8
Protein
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false