Inner centromere protein (INCENP) is a component of the chromosomal passenger complex (CPC), which is an important regulator of mitosis. CPC ensures correct alignment and segregation of chromosomes at the centromere. INCENT interacts with several other CPC subunits [, , ]and it activates subunits AURKB and AURKC []; it also interacts with the tubulin beta chain []. Two paralogues exist in Xenopus named INCEP A and B.
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N-terminal domain is the domain involved in formation of this three helical bundle.
