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Search results 301 to 400 out of 408 for Stx1a

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Type Details Score
Publication
11493566 | J:70746
First Author: Brown NL
Year: 2001
Journal: Development
Title: Math5 is required for retinal ganglion cell and optic nerve formation.
Volume: 128
Issue: 13
Pages: 2497-508
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Publication
15363391 | J:92622
First Author: Li S
Year: 2004
Journal: Neuron
Title: Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.
Volume: 43
Issue: 6
Pages: 795-807
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Publication
21856951 | J:175224
First Author: Ohta K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Volume: 108
Issue: 36
Pages: 14962-7
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Publication
20881139 | J:164874
First Author: Wang L
Year: 2010
Journal: J Neurosci
Title: The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.
Volume: 30
Issue: 39
Pages: 13201-10
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Publication
8630490 | J:32083
First Author: Burmeister M
Year: 1996
Journal: Nat Genet
Title: Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
Volume: 12
Issue: 4
Pages: 376-84
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Publication
18507827 | J:137605
 
First Author: Manuel M
Year: 2008
Journal: BMC Dev Biol
Title: Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.
Volume: 8
Pages: 59
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Publication
18224708 | J:131815
First Author: Pontoriero GF
Year: 2008
Journal: Dev Dyn
Title: Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
Volume: 237
Issue: 3
Pages: 602-17
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Publication
32994318 | J:297493
 
First Author: Matos-Rodrigues GE
Year: 2020
Journal: Dis Model Mech
Title: Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.
Volume: 13
Issue: 10
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Publication
15604100 | J:95327
First Author: de Melo J
Year: 2005
Journal: Development
Title: Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.
Volume: 132
Issue: 2
Pages: 311-22
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Publication
12619134 | J:82209
First Author: Kablar B
Year: 2003
Journal: Dev Dyn
Title: Determination of retinal cell fates is affected in the absence of extraocular striated muscles.
Volume: 226
Issue: 3
Pages: 478-90
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Publication
15145078 | J:91381
First Author: Bouwman J
Year: 2004
Journal: Neuroscience
Title: Quantification of synapse formation and maintenance in vivo in the absence of synaptic release.
Volume: 126
Issue: 1
Pages: 115-26
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Publication
15935055 | J:99424
First Author: Toonen RF
Year: 2005
Journal: J Neurochem
Title: Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.
Volume: 93
Issue: 6
Pages: 1393-400
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Publication
15733660 | J:96667
First Author: Philips GT
Year: 2005
Journal: Dev Biol
Title: Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.
Volume: 279
Issue: 2
Pages: 308-21
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Publication
17301087 | J:119184
First Author: Nakhai H
Year: 2007
Journal: Development
Title: Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina.
Volume: 134
Issue: 6
Pages: 1151-60
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Publication
15797020 | J:97089
First Author: Mu X
Year: 2005
Journal: Curr Biol
Title: Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina.
Volume: 15
Issue: 6
Pages: 525-30
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Publication
20107170 | J:165076
First Author: Cammas L
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.
Volume: 51
Issue: 6
Pages: 3281-90
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Publication
14625556 | J:86636
First Author: Nishida A
Year: 2003
Journal: Nat Neurosci
Title: Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.
Volume: 6
Issue: 12
Pages: 1255-63
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Publication
12588844 | J:81579
First Author: Aguado F
Year: 2003
Journal: Development
Title: BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.
Volume: 130
Issue: 7
Pages: 1267-80
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Publication
23652001 | J:205743
 
First Author: Liu H
Year: 2013
Journal: Nat Commun
Title: An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.
Volume: 4
Pages: 1813
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Publication
16267237 | J:102364
First Author: Koike C
Year: 2005
Journal: J Neurosci
Title: Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.
Volume: 25
Issue: 44
Pages: 10290-8
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Publication
17124501 | J:119934
First Author: Schoch S
Year: 2006
Journal: EMBO J
Title: Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Volume: 25
Issue: 24
Pages: 5852-63
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Publication
29249622 | J:253963
First Author: Moon KH
Year: 2018
Journal: Dev Cell
Title: Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.
Volume: 44
Issue: 1
Pages: 13-28.e3
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Publication
32071286 | J:339443
First Author: Zocchi L
Year: 2020
Journal: Oncogenesis
Title: Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression.
Volume: 9
Issue: 2
Pages: 25
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Publication
22411557 | J:181601
First Author: Bassett EA
Year: 2012
Journal: Dev Dyn
Title: Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.
Volume: 241
Issue: 4
Pages: 814-29
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Publication
25971728 | J:223313
First Author: Zembrzycki A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2.
Volume: 112
Issue: 21
Pages: 6736-41
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Publication
25966682 | J:302827
 
First Author: Jin K
Year: 2015
Journal: Mol Brain
Title: Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.
Volume: 8
Pages: 28
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Publication
36459087 | J:331692
   
First Author: Xin Y
Year: 2022
Journal: Elife
Title: m(6)A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.
Volume: 11
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Publication
18094249 | J:130904
First Author: Poché RA
Year: 2007
Journal: J Neurosci
Title: Lim1 is essential for the correct laminar positioning of retinal horizontal cells.
Volume: 27
Issue: 51
Pages: 14099-107
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Publication
32744119 | J:303303
   
First Author: Pan M
Year: 2020
Journal: Autophagy
Title: Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
Pages: 1-16
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Publication
11779826 | J:73830
First Author: DeSilva U
Year: 2002
Journal: Genome Res
Title: Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
Volume: 12
Issue: 1
Pages: 3-15
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Publication
11013070 | J:65086
First Author: Valero MC
Year: 2000
Journal: Genomics
Title: Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).
Volume: 69
Issue: 1
Pages: 1-13
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Publication
16026391 | J:101317
First Author: Stewart L
Year: 2005
Journal: J Neurochem
Title: Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.
Volume: 94
Issue: 6
Pages: 1739-45
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Publication
31609468 | J:286828
First Author: Jiang D
Year: 2020
Journal: J Comp Neurol
Title: Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.
Volume: 528
Issue: 5
Pages: 729-755
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Publication
25228773 | J:216471
First Author: Sapkota D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.
Volume: 111
Issue: 39
Pages: E4086-95
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Publication
26758845 | J:228865
First Author: Law C
Year: 2016
Journal: J Neurosci
Title: Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.
Volume: 36
Issue: 2
Pages: 561-76
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Publication
21138975 | J:180843
First Author: Davis N
Year: 2011
Journal: Development
Title: Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium.
Volume: 138
Issue: 1
Pages: 127-38
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Publication
29950673 | J:266104
First Author: Choi JH
Year: 2018
Journal: Nat Commun
Title: mTORC1 accelerates retinal development via the immunoproteasome.
Volume: 9
Issue: 1
Pages: 2502
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
30728831 | J:304253
 
First Author: Jones MR
Year: 2018
Journal: Front Genet
Title: A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.
Volume: 9
Pages: 746
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Publication
30995482 | J:281311
First Author: Nakano Y
Year: 2019
Journal: Cell Rep
Title: Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Volume: 27
Issue: 3
Pages: 860-871.e8
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Publication
- | J:72400
       
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21900493 | -
First Author: Shi L
Year: 2011
Journal: Mol Biol Cell
Title: Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex.
Volume: 22
Issue: 21
Pages: 4150-60
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Allele
Tg(Stx1a-EGFP)FV144Gsat | MGI:4847465
Name: transgene insertion FV144, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003623 | STOCK Tg(Stx1a-EGFP)FV144Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
12403834 | -
First Author: MacDonald PE
Year: 2002
Journal: Mol Endocrinol
Title: Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
Volume: 16
Issue: 11
Pages: 2452-61
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Publication
10336434 | -
First Author: Fasshauer D
Year: 1999
Journal: J Biol Chem
Title: Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties.
Volume: 274
Issue: 22
Pages: 15440-6
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Protein Domain
IPR039077 | SNAP-25
Type: Family
Description: SNARE proteins are involved in the fusion of vesicles with their target membranes. Synaptosomal-associated protein 25 (SNAP-25) regulates Kv2.1 voltage-dependent K(+) channels in pancreatic beta cells []. It may also play a role in neurotansmiiter release form the synapse. It is a component of the SNARE core complex, which also includes VAMP2 and STX1A [, ]. In some fish species (goldfish, zebrafish) there are two homologues known as SNAP-25A and SNAP-25B.
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Publication
29139159 | J:273770
First Author: Fujiwara T
Year: 2017
Journal: Eur J Neurosci
Title: Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Volume: 46
Issue: 12
Pages: 2867-2874
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Publication
26203110 | J:238616
First Author: Wu YJ
Year: 2015
Journal: J Neurophysiol
Title: Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Volume: 114
Issue: 4
Pages: 2404-17
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Publication
17270452 | J:134730
First Author: van Hagen JM
Year: 2007
Journal: Neurobiol Dis
Title: Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.
Volume: 26
Issue: 1
Pages: 112-24
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Publication
32312867 | J:293286
First Author: Liu S
Year: 2020
Journal: Diabetes
Title: Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells.
Volume: 69
Issue: 6
Pages: 1178-1192
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Publication
37432648 | J:344888
First Author: Rahman MM
Year: 2023
Journal: FASEB J
Title: Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
Volume: 37
Issue: 8
Pages: e23075
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Publication
20150444 | J:158605
First Author: Groffen AJ
Year: 2010
Journal: Science
Title: Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Volume: 327
Issue: 5973
Pages: 1614-8
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Publication
8902635 | J:39762
First Author: Kojima T
Year: 1996
Journal: J Biochem
Title: Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).
Volume: 120
Issue: 3
Pages: 671-6
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Publication
19033398 | J:146942
First Author: Fukuda N
Year: 2009
Journal: Diabetes
Title: DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes.
Volume: 58
Issue: 2
Pages: 377-84
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Publication
9759724 | -
First Author: Sutton RB
Year: 1998
Journal: Nature
Title: Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.
Volume: 395
Issue: 6700
Pages: 347-53
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Publication
22698913 | J:208531
First Author: Ramalingam L
Year: 2012
Journal: Diabetes
Title: Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.
Volume: 61
Issue: 10
Pages: 2424-32
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Publication
25005332 | J:218125
First Author: Li J
Year: 2014
Journal: Diabetologia
Title: DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.
Volume: 57
Issue: 10
Pages: 2173-82
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Publication
16515538 | J:108537
First Author: Groffen AJ
Year: 2006
Journal: J Neurochem
Title: DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.
Volume: 97
Issue: 3
Pages: 818-33
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Publication
22036572 | J:178686
First Author: Yao J
Year: 2011
Journal: Cell
Title: Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Volume: 147
Issue: 3
Pages: 666-77
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Publication
20403080 | -
First Author: Sato M
Year: 2010
Journal: J Neurochem
Title: Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.
Volume: 114
Issue: 1
Pages: 171-81
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Protein Domain
IPR030535 | Doc2a/b
Type: Family
Description: Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ].
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Protein
D3Z126
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
P60879
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
D3YZ51
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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