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Search results 401 to 442 out of 442 for Ddr2

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Type Details Score
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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HT Experiment
GSE212281 | Single-cell RNA sequencing of Ddr2 slie/slie and littermate control
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
37527178 | J:343638
First Author: Schab AM
Year: 2023
Journal: Mol Cancer Res
Title: Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins.
Volume: 21
Issue: 11
Pages: 1234-1248
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Publication
34477203 | J:318713
 
First Author: Barcus CE
Year: 2021
Journal: J Cell Sci
Title: Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis.
Volume: 134
Issue: 19
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Publication
22328973 | -
First Author: Hammerman PS
Year: 2011
Journal: Cancer Discov
Title: Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
Volume: 1
Issue: 1
Pages: 78-89
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Allele
Ddr2<em2Smoc> | MGI:7289302
Name: discoidin domain receptor family, member 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428525 | C57BL/6J-Ddr2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Ddr2<em1Smoc> | MGI:7289301
Name: discoidin domain receptor family, member 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tg(tetO-DDR2)#Yeli | MGI:6270427
Name: transgene insertion, Yefu Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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DO Term
DOID:0112196 | spondylometaepiphyseal dysplasia, short limb-hand type
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Strain
MGI:6475110 | C57BL/6J-Ddr2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Ddr2<slie> | MGI:3640081
 
Name: discoidin domain receptor family, member 2; smallie
Allele Type: Spontaneous
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Publication
21855682 | J:176308
First Author: Xu L
Year: 2011
Journal: Am J Pathol
Title: Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model.
Volume: 179
Issue: 3
Pages: 1338-46
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Strain
MGI:3785261 | BKS(HRS)-Ddr2<slie>/JngJ
Attribute String: spontaneous mutation
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Genotype
Genotype
Symbol: Ddr2/Ddr2
Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpe/LtJng
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ddr2/Ddr2
Background: involves: C57BLKS/J * HRS/J
Zygosity: hm
Has Mutant Allele: true
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Publication
12065315 | J:109760
First Author: Hou G
Year: 2002
Journal: Circ Res
Title: Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.
Volume: 90
Issue: 11
Pages: 1147-9
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Publication
9659900 | -
First Author: Shrivastava A
Year: 1997
Journal: Mol Cell
Title: An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
Volume: 1
Issue: 1
Pages: 25-34
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Publication
17665456 | -
First Author: Xu L
Year: 2007
Journal: Arthritis Rheum
Title: Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.
Volume: 56
Issue: 8
Pages: 2663-73
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Publication
24781958 | -
First Author: Márquez J
Year: 2014
Journal: Histol Histopathol
Title: Role of discoidin domain receptor 2 in wound healing.
Volume: 29
Issue: 11
Pages: 1355-64
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Publication
20884741 | -
First Author: Roberts ME
Year: 2011
Journal: Eur Respir J
Title: Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production.
Volume: 37
Issue: 6
Pages: 1482-93
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Publication
16234985 | -
First Author: Ram R
Year: 2006
Journal: J Neurooncol
Title: Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.
Volume: 76
Issue: 3
Pages: 239-48
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Publication
24768818 | -
First Author: Canning P
Year: 2014
Journal: J Mol Biol
Title: Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
Volume: 426
Issue: 13
Pages: 2457-70
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Protein Domain
IPR034299 | DDR1/DDR2
Type: Family
Description: The discoidin domain-containing receptor (DDR) family includes DDR1 and DDR2. DDR family members are receptor tyrosine kinases (RTKs) whose activating ligands are various collagens []. The proteins contain an extracellular discoidin domain, which binds various collagen proteins, and an intracellular tyrosine kinase domain.DDR2 may have a role in wound healing; DDR2 signalling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing []. Increased expression of DDR2 may also be important in the pathogenesis of osteoarthritis [], and there is evidence that the receptor could be implicated in certain forms of cancer - mutations in the DDR2 kinase gene have been detected in ~ 4% of squamous cell lung cancers [].Epithelial discoidin domain-containing receptor 1 (also known as DDR1) is involved in smooth muscle cell migration and matrix metalloproteinase expression []. It is responsible for maintaining the normal structure of skin and kidney epithelia []. The receptor may play a critical role in inducing tumour cell adhesion and invasion []. Itsstructure has been solved [].
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Genotype
Genotype
Symbol: Tg(Comp-tTA)#Yeli/? Tg(tetO-DDR2)#Yeli/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Publication
9659899 | J:47333
First Author: Vogel W
Year: 1997
Journal: Mol Cell
Title: The discoidin domain receptor tyrosine kinases are activated by collagen.
Volume: 1
Issue: 1
Pages: 13-23
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Protein
G3UXE5
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: true
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Protein
Q6NZR6
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
B0V2H8
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
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Protein
D6RII6
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Publication
22019896 | J:180270
First Author: Olaso E
Year: 2011
Journal: Am J Pathol
Title: Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages.
Volume: 179
Issue: 6
Pages: 2894-904
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Publication
24787381 | J:217038
First Author: Yan Z
Year: 2014
Journal: Biochim Biophys Acta
Title: Discoidin domain receptor 2 facilitates prostate cancer bone metastasis via regulating parathyroid hormone-related protein.
Volume: 1842
Issue: 9
Pages: 1350-63
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Publication
25130389 | J:216173
First Author: Ren T
Year: 2014
Journal: J Pathol
Title: Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia.
Volume: 234
Issue: 4
Pages: 526-37
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Protein
Q62371
Organism: Mus musculus/domesticus
Length: 854  
Fragment?: false
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Protein
Q03146
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
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Protein
Q544T2
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
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Protein
Q05BN5
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: true
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Protein
O35407
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
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