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Search results 101 to 200 out of 234 for Pex5

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Type Details Score
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1795023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6881
Specimen Label: GUDMAP:6881
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1795023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1869223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2853323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5000679
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3152723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541239
Age: embryonic day 15.5
Image: GUDMAP:6882
Specimen Label: GUDMAP:6882
Detected: true
Specimen Num: 2
Publication
First Author: Bottelbergs A
Year: 2010
Journal: Glia
Title: Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes.
Volume: 58
Issue: 13
Pages: 1532-43
Publication
First Author: Shepard AR
Year: 2007
Journal: Hum Mol Genet
Title: Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
Volume: 16
Issue: 6
Pages: 609-17
Publication
First Author: Baes M
Year: 1997
Journal: Nat Genet
Title: A mouse model for Zellweger syndrome.
Volume: 17
Issue: 1
Pages: 49-57
Publication
First Author: Huyghe S
Year: 2006
Journal: Endocrinology
Title: Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.
Volume: 147
Issue: 5
Pages: 2228-36
Publication  
First Author: Bottelbergs A
Year: 2012
Journal: J Neuroinflammation
Title: Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system.
Volume: 9
Pages: 61
Publication
First Author: Dirkx R
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts.
Volume: 357
Issue: 3
Pages: 718-23
Publication
First Author: Yakunin E
Year: 2010
Journal: J Neurosci Res
Title: alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders.
Volume: 88
Issue: 4
Pages: 866-76
Publication
First Author: Björkman J
Year: 2002
Journal: Genomics
Title: Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes.
Volume: 79
Issue: 2
Pages: 162-8
Publication
First Author: Huyghe S
Year: 2001
Journal: Biochem J
Title: Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse.
Volume: 353
Issue: Pt 3
Pages: 673-80
Publication
First Author: Tchernev VT
Year: 1997
Journal: Genomics
Title: Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.
Volume: 40
Issue: 1
Pages: 170-4
Publication
First Author: Bettenhausen B
Year: 1995
Journal: Genomics
Title: Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.
Volume: 28
Issue: 3
Pages: 436-41
Publication      
First Author: Copeland NG
Year: 1999
Journal: Database Release
Title: Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data
Publication
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Miyata N
Year: 2012
Journal: Traffic
Title: AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.
Volume: 13
Issue: 1
Pages: 168-83
Publication
First Author: Ito R
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.
Volume: 288
Issue: 2
Pages: 321-7
Publication
First Author: Ramón NM
Year: 2010
Journal: Mol Biol Cell
Title: Interdependence of the peroxisome-targeting receptors in Arabidopsis thaliana: PEX7 facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes.
Volume: 21
Issue: 7
Pages: 1263-71
DO Term
DO Term
GO Term
Publication
First Author: Neufeld C
Year: 2009
Journal: EMBO J
Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Volume: 28
Issue: 6
Pages: 745-54
Publication
First Author: Chang CC
Year: 1999
Journal: J Cell Biol
Title: PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.
Volume: 147
Issue: 4
Pages: 761-74
DO Term
Publication
First Author: Bankston JR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
Volume: 109
Issue: 20
Pages: 7899-904
Publication
First Author: Han Y
Year: 2020
Journal: Channels (Austin)
Title: The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels.
Volume: 14
Issue: 1
Pages: 110-122
Protein Domain
Type: Family
Description: Peroxisomal proteins catalyse metabolic reactions. The import of proteins from the cytosol into the peroxisomes matrix depends on more than a dozen peroxin (PEX) proteins, among which PEX5 and PEX7 serve as receptors that shuttle proteins bearing one of two peroxisome-targeting signals (PTSs) into the organelle. PEX5 is the PTS1 receptor, while PEX7 is the PTS2 receptor. In plants, PEX7 depends on PEX5 binding to deliver PTS2 cargo into the peroxisome, and PEX7 also facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes [, ]. This entry include PEX5 (also known as PTS1R) from animals, fungi and plants. This entry also includes PEX5L from vertebrates. PEX5 binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import [, , ]. Based on subcellular localization and binding properties mammalian PEX5 may function as a regulator in an early step of the PTS1 protein import process []. PEX5L acts as an accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence [, ]. Interestingly, although PEX5 and PEX5L have structurally similar binding at their TPR domains, they bind to different substrates in vivo [].
Publication
First Author: Ito R
Year: 2005
Journal: J Biochem
Title: Identification of Pex5pM, and retarded maturation of 3-ketoacyl-CoA thiolase and acyl-CoA oxidase in CHO cells expressing mutant Pex5p isoforms.
Volume: 138
Issue: 6
Pages: 781-90
Publication
First Author: Otera H
Year: 2002
Journal: Mol Cell Biol
Title: Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.
Volume: 22
Issue: 6
Pages: 1639-55
Publication
First Author: Woodward AW
Year: 2005
Journal: Mol Biol Cell
Title: The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5.
Volume: 16
Issue: 2
Pages: 573-83
Publication
First Author: Braverman N
Year: 1997
Journal: Nat Genet
Title: Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata.
Volume: 15
Issue: 4
Pages: 369-76
Publication
First Author: van den Brink DM
Year: 2003
Journal: Am J Hum Genet
Title: Identification of PEX7 as the second gene involved in Refsum disease.
Volume: 72
Issue: 2
Pages: 471-7
Publication
First Author: Marzioch M
Year: 1994
Journal: EMBO J
Title: PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes.
Volume: 13
Issue: 20
Pages: 4908-18
Protein Domain
Type: Family
Description: Peroxisomal proteins catalyse metabolic reactions. The import of proteins from the cytosol into the peroxisomes matrix depends on more than a dozen peroxin (PEX) proteins, among which PEX5 and PEX7 serve as receptors that shuttle proteins bearing one of two peroxisome-targeting signals (PTSs) into the organelle. PEX5 is the PTS1 receptor, while PEX7 is the PTS2 receptor. In plants, PEX7 depends on PEX5 binding to deliver PTS2 cargo into the peroxisome, and PEX7 also facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes [, ]. This entry represents PEX7 from animals, fungi and plants. In plants it plays important roles in embryonic development, seedling establishment, and vegetative growth []. Budding yeast PEX7 homologue, Pas7, is necessary for import of thiolase (a PTS2-containing protein) []. In humans PEX7 has been linked to several diseases, such as Rhizomelic chondrodysplasia punctata 1 (RCDP1) []and Peroxisome biogenesis disorder 9B (PBD9B) [].
Publication
First Author: El Magraoui F
Year: 2014
Journal: PLoS One
Title: The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.
Volume: 9
Issue: 8
Pages: e105894
Publication
First Author: Zolman BK
Year: 2005
Journal: Plant Cell
Title: Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22.
Volume: 17
Issue: 12
Pages: 3422-35
Protein Domain
Type: Family
Description: Peroxisomal proteins, called peroxins, participate in the process of peroxisome assembly. Specific amino acid sequences (PTS or peroxisomal targeting signal) at the C terminus (PTS1) or N terminus (PTS2) are present in peroxisomal matrix proteins, which signals them to be imported. The protein receptors Pex5 and Pex7 accompany their cargoes (containing a PTS1 or a PTS2 amino acid sequence, respectively) into the peroxisome. Ubiquitination appears to be crucial for the export of Pex5 from the peroxisome to the cytosol. The monoubiquitination of the PTS1-receptor Pex5p is catalyzed by the E2 enzyme Pex4.Pex22 anchors Pex4 to the peroxisome membrane [, ]. Moreover, Pex4 requires the interaction with Pex22 to display full activity []. The N-terminal portion of Pex22 has a membrane anchoring function, whereas the C-terminal domain harbours its biological activity. The soluble C-terminal domain of Pex22 is essential for peroxisomal biogenesis and efficient monoubiquitination of the import receptor Pex5 [].
Protein Domain
Type: Family
Description: This entry represents the PEX5-related proteins (PEX5L, also known as TRIP8b) from vertebrates. It acts as an accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence [, ]. Interestingly, although PEX5L and PEX5 have structurally similar binding at their TPR domains, they bind to different substrates in vivo [].
Protein Domain
Type: Family
Description: Peroxisome biogenesis factor 1, also known as peroxin-1 or PEX1, is a component of the peroxisomal protein import machinery. In addition to its role in import, PEX1 together with PEX6, mediates the ATP-dependent relocation and recycling of the peroxisomal targeting signal-1 (PTS1) import receptor PEX5 from the peroxisomal membrane to the cytosol [, , ].
Publication
First Author: Birschmann I
Year: 2005
Journal: FEBS J
Title: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p.
Volume: 272
Issue: 1
Pages: 47-58
Publication
First Author: Platta HW
Year: 2005
Journal: Nat Cell Biol
Title: Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.
Volume: 7
Issue: 8
Pages: 817-22
Publication
First Author: Rosenkranz K
Year: 2006
Journal: FEBS J
Title: Functional association of the AAA complex and the peroxisomal importomer.
Volume: 273
Issue: 16
Pages: 3804-15
Publication
First Author: Williams C
Year: 2006
Journal: Biochim Biophys Acta
Title: Pex13p: docking or cargo handling protein?
Volume: 1763
Issue: 12
Pages: 1585-91
Publication
First Author: Stein K
Year: 2002
Journal: Mol Cell Biol
Title: Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import.
Volume: 22
Issue: 17
Pages: 6056-69
Protein Domain
Type: Family
Description: Peroxin-13 (Pex13), located in the peroxisomal membrane, is a component of the peroxisomal translocation machinery with peroxin-14 and peroxin-17. Both termini of peroxin-13 are oriented to the cytosol. It is required for peroxisomal association of peroxin-14 []. Both human and budding yeast Pex13 bind to the PTS1 signal recognition factor Pex5. However, they bind to Pex5 through different binding sites []. In budding yeasts, Pex13 is also involved in the PTS2 signal recognition through its interaction with Pex7 [].
Publication
First Author: Koller A
Year: 1999
Journal: J Cell Biol
Title: Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane.
Volume: 146
Issue: 1
Pages: 99-112
Publication
First Author: Williams C
Year: 2012
Journal: EMBO J
Title: Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.
Volume: 31
Issue: 2
Pages: 391-402
Protein
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 639  
Fragment?: false