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Search results 1 to 100 out of 672 for Pth1r

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0.093s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:6469659
Assay Type: RNA in situ
Annotation Date: 2020-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6469690
Age: embryonic day 9.5
Image: 7 E9.5 Pth1r
Note: Expression in mandibular arch.
Specimen Label: 7 E9.5 Pth1r
Detected: true
Specimen Num: 1
Publication  
First Author: Daley EJ
Year: 2022
Journal: Endocrinology
Title: Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
Volume: 163
Issue: 7
Publication
First Author: Amano K
Year: 2024
Journal: J Dent Res
Title: Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation.
Volume: 103
Issue: 3
Pages: 308-317
Publication
First Author: Pickard BW
Year: 2006
Journal: Endocrinology
Title: Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.
Volume: 147
Issue: 7
Pages: 3326-32
Publication  
First Author: Yang H
Year: 2019
Journal: Int J Mol Sci
Title: Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Volume: 20
Issue: 15
Publication  
First Author: Amano K
Year: 2016
Journal: Bone
Title: Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.
Volume: 83
Pages: 256-66
Publication
First Author: Kadmiel M
Year: 2017
Journal: PLoS One
Title: Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation.
Volume: 12
Issue: 7
Pages: e0181597
Publication
First Author: Qiu T
Year: 2015
Journal: J Bone Miner Res
Title: PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate.
Volume: 30
Issue: 2
Pages: 309-17
Publication
First Author: Qian J
Year: 2003
Journal: Endocrinology
Title: Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death.
Volume: 144
Issue: 3
Pages: 1053-61
Publication
First Author: Delgado-Calle J
Year: 2017
Journal: J Bone Miner Res
Title: Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor.
Volume: 32
Issue: 3
Pages: 522-535
Publication
First Author: Qiu T
Year: 2010
Journal: Nat Cell Biol
Title: TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.
Volume: 12
Issue: 3
Pages: 224-34
Publication
First Author: Standal T
Year: 2014
Journal: J Endocrinol
Title: gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
Volume: 223
Issue: 2
Pages: 181-90
Publication  
First Author: Swami S
Year: 2023
Journal: JCI Insight
Title: Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice.
Volume: 8
Issue: 5
Publication
First Author: Fan Y
Year: 2016
Journal: FASEB J
Title: Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis.
Volume: 30
Issue: 1
Pages: 428-40
Publication
First Author: Weaver SR
Year: 2021
Journal: J Bone Miner Res
Title: Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth.
Volume: 36
Issue: 5
Pages: 986-999
Publication
First Author: Mahon MJ
Year: 2006
Journal: Mol Endocrinol
Title: A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.
Volume: 20
Issue: 1
Pages: 136-46
Publication
First Author: Izquierdo A
Year: 2006
Journal: Kidney Int
Title: The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes.
Volume: 69
Issue: 12
Pages: 2171-7
Publication
First Author: Atchison DK
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release.
Volume: 303
Issue: 8
Pages: F1157-65
Publication
First Author: Delgado-Calle J
Year: 2018
Journal: FASEB J
Title: MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.
Volume: 32
Issue: 5
Pages: 2878-2890
Publication
First Author: Nishimori S
Year: 2019
Journal: J Clin Invest
Title: Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
Volume: 129
Issue: 12
Pages: 5187-5203
Publication
First Author: Behrmann A
Year: 2020
Journal: Circ Res
Title: PTH/PTHrP Receptor Signaling Restricts Arterial Fibrosis in Diabetic LDLR(-/-) Mice by Inhibiting Myocardin-Related Transcription Factor Relays.
Volume: 126
Issue: 10
Pages: 1363-1378
Publication
First Author: Tsutsumi-Arai C
Year: 2024
Journal: J Dent Res
Title: A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.
Volume: 103
Issue: 1
Pages: 91-100
Publication
First Author: Ide N
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.
Volume: 315
Issue: 5
Pages: F1261-F1270
Publication
First Author: Probst S
Year: 2013
Journal: Differentiation
Title: The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development.
Volume: 85
Issue: 4-5
Pages: 121-30
GXD Expression  
Probe: MGI:6753249
Assay Type: In situ reporter (knock in)
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3657226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7645376
Age: embryonic day 18.5
Note: Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen Label: 2B Control PTH1R
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6753249
Assay Type: In situ reporter (knock in)
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3657226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7645376
Age: embryonic day 18.5
Note: Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen Label: 2B KO PTH1R
Detected: true
Specimen Num: 8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Karperien M
Year: 1994
Journal: Mech Dev
Title: Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes.
Volume: 47
Issue: 1
Pages: 29-42
Publication
First Author: McCuaig KA
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor.
Volume: 91
Issue: 11
Pages: 5051-5
Publication
First Author: Panaroni C
Year: 2015
Journal: J Bone Miner Res
Title: PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.
Volume: 30
Issue: 12
Pages: 2273-86
Publication
First Author: Gardinier JD
Year: 2019
Journal: PLoS One
Title: Loss of the PTH/PTHrP receptor along the osteoblast lineage limits the anabolic response to exercise.
Volume: 14
Issue: 1
Pages: e0211076
Publication
First Author: Fan Y
Year: 2017
Journal: Cell Metab
Title: Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.
Volume: 25
Issue: 3
Pages: 661-672
Publication
First Author: Kobayashi T
Year: 2005
Journal: Dev Dyn
Title: Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation.
Volume: 233
Issue: 3
Pages: 794-803
Publication
First Author: Ramirez MI
Year: 2000
Journal: Am J Respir Cell Mol Biol
Title: Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice.
Volume: 22
Issue: 3
Pages: 367-72
Publication
First Author: Saini V
Year: 2013
Journal: J Biol Chem
Title: Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH.
Volume: 288
Issue: 28
Pages: 20122-34
Publication  
First Author: Dedic C
Year: 2018
Journal: Bone
Title: Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes.
Volume: 116
Pages: 135-143
Publication
First Author: Hirai T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.
Volume: 108
Issue: 1
Pages: 191-6
Publication
First Author: Powell WF Jr
Year: 2011
Journal: J Endocrinol
Title: Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses.
Volume: 209
Issue: 1
Pages: 21-32
Publication
First Author: Bounoutas GS
Year: 2006
Journal: Endocrinology
Title: Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor.
Volume: 147
Issue: 10
Pages: 4674-9
Publication
First Author: Maeda A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Volume: 110
Issue: 15
Pages: 5864-9
Publication
First Author: Rhee Y
Year: 2013
Journal: J Biol Chem
Title: Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes.
Volume: 288
Issue: 41
Pages: 29809-20
Publication
First Author: Calvi LM
Year: 2001
Journal: J Clin Invest
Title: Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.
Volume: 107
Issue: 3
Pages: 277-86
Publication
First Author: Ono N
Year: 2012
Journal: J Cell Physiol
Title: Constitutively active PTH/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation.
Volume: 227
Issue: 2
Pages: 408-15
Publication
First Author: Ono N
Year: 2007
Journal: J Biol Chem
Title: Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption.
Volume: 282
Issue: 35
Pages: 25509-16
Publication
First Author: McCuaig KA
Year: 1995
Journal: Nucleic Acids Res
Title: Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters.
Volume: 23
Issue: 11
Pages: 1948-55
Publication
First Author: Amizuka N
Year: 1997
Journal: Endocrinology
Title: Cell-specific expression of the parathyroid hormone (PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters.
Volume: 138
Issue: 1
Pages: 469-81
Publication
First Author: Joun H
Year: 1997
Journal: Endocrinology
Title: Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene: a new PTH/PTHrP receptor splice variant that lacks the signal peptide.
Volume: 138
Issue: 4
Pages: 1742-9
Publication
First Author: Noonan WT
Year: 2003
Journal: Endocrinology
Title: Altered renal hemodynamics in mice overexpressing the parathyroid hormone (PTH)/PTH-related peptide type 1 receptor in smooth muscle.
Volume: 144
Issue: 11
Pages: 4931-8
Publication
First Author: Tsutsui TW
Year: 2008
Journal: Bone
Title: Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor.
Volume: 42
Issue: 2
Pages: 321-31
Publication
First Author: Marzan CV
Year: 2011
Journal: Dev Biol
Title: Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors.
Volume: 349
Issue: 2
Pages: 125-36
GXD Expression      
Probe: MGI:3693776
Assay Type: RT-PCR
Annotation Date: 2007-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1771322
Stage: TS22
Assay Id: MGI:3693775
Age: embryonic day 14.5
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:3693776
Assay Type: RT-PCR
Annotation Date: 2007-01-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1771322
Stage: TS22
Assay Id: MGI:3693775
Age: embryonic day 14.5
Specimen Label: Runx2-/-
Specimen Num: 2
GXD Expression    
Probe: MGI:6194857
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194890
Age: embryonic day 16.5
Image: 4
Specimen Label: a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6194857
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194890
Age: embryonic day 16.5
Image: 4
Specimen Label: b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6194857
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194890
Age: embryonic day 16.5
Image: 4
Specimen Label: c
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6194857
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194890
Age: embryonic day 16.5
Image: 4
Specimen Label: d
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3043195
Assay Type: Northern blot
Annotation Date: 2004-06-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1802526
Stage: TS26
Assay Id: MGI:3043285
Age: embryonic day 18.5
Image: 9
Specimen Label: +/+
Specimen Num: 1
GXD Expression    
Probe: MGI:3043195
Assay Type: Northern blot
Annotation Date: 2004-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1802526
Stage: TS26
Assay Id: MGI:3043285
Age: embryonic day 18.5
Image: 9
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6273184
Assay Type: RT-PCR
Annotation Date: 2019-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273022
Stage: TS22
Assay Id: MGI:6273234
Age: embryonic day 14.5
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6273184
Assay Type: RT-PCR
Annotation Date: 2019-01-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273022
Stage: TS22
Assay Id: MGI:6273234
Age: embryonic day 14.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7384287
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273023
Stage: TS23
Assay Id: MGI:7384291
Age: embryonic day 15.5
Image: 6
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7384287
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273023
Stage: TS23
Assay Id: MGI:7384291
Age: embryonic day 15.5
Image: 6
Specimen Label: wt
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7384287
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273023
Stage: TS23
Assay Id: MGI:7384291
Age: embryonic day 15.5
Image: 6
Specimen Label: wt
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7384287
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273023
Stage: TS23
Assay Id: MGI:7384291
Age: embryonic day 15.5
Image: 6
Specimen Label: wt
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3846634
Assay Type: RNA in situ
Annotation Date: 2009-06-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3846695
Age: embryonic day 15.5
Image: 9J,K
Note: Intense expression in mesenchymal cells that morphologically resemble chondrocytes.
Specimen Label: 9J,K
Detected: true
Specimen Num: 38
GXD Expression  
Probe: MGI:4415933
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1912823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827511
Age: embryonic day 14.5
Image: euxassay_011503_02
Specimen Label: euxassay_011503_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4415933
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1912823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827511
Age: embryonic day 14.5
Image: euxassay_011503_03
Specimen Label: euxassay_011503_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4415933
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1912823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827511
Age: embryonic day 14.5
Image: euxassay_011503_20
Specimen Label: euxassay_011503_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4415933
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1912823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827511
Age: embryonic day 14.5
Image: euxassay_011503_21
Specimen Label: euxassay_011503_21
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:7730808
Assay Type: RNA in situ
Annotation Date: 2024-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1613319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7734966
Age: embryonic day 11.5
Specimen Label: 1B
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:3620984
Assay Type: RNA in situ
Annotation Date: 2006-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3262622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3621142
Age: embryonic day 14.5
Image: 3H
Note: Expression is in early hypertrophic chondrocytes.
Specimen Label: 3H
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3846634
Assay Type: RNA in situ
Annotation Date: 2009-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1742020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3846695
Age: embryonic day 12.5
Image: 9L,M
Note: Expression begins in the middle of condensing mesenchymal cells that form the humerus, ulna and radius.
Specimen Label: 9L,M
Detected: true
Specimen Num: 39
GXD Expression
Probe: MGI:3846634
Assay Type: RNA in situ
Annotation Date: 2009-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3262523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3846695
Age: embryonic day 15.5
Image: 9N,O
Note: Expression restricted to chondrocytes adjacent to hypertrophic chondrocytes and to the perichondrium.
Specimen Label: 9N,O
Detected: true
Specimen Num: 40