Shedding of transmembrane protein 35 (TMEM35) produces a soluble peptide that may modulate neurite outgrowth in the adrenal zona glomerulosa after sodium depletion []. TMEM35 could be required for normal activity of the hypothalamic-pituitary-adrenal axis and limbic circuitry [].TMEM35A, also known as NACHO, acts as a acetylcholine receptor chaperone that mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain [].
