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Search results 201 to 289 out of 289 for Lipa

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0.034s
Type Details Score
GXD Expression
Probe: MGI:893645
Assay Type: RNA in situ
Annotation Date: 2008-11-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3565128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3814426
Age: postnatal adult
Image: 3h
Note: There was strong expression in the acinar cells.
Specimen Label: 3h
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:893645
Assay Type: RNA in situ
Annotation Date: 2008-11-11
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3565128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3814426
Age: postnatal adult
Note: Expression is very strong in the acinar cells.
Specimen Label: Table I
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Image: MH2838; Specimen C3648
Specimen Label: MH2838; Specimen C3648
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:893645
Assay Type: RNA in situ
Annotation Date: 2008-11-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3586328
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3814426
Age: postnatal adult
Image: 3d
Specimen Label: 3d
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:893645
Assay Type: RNA in situ
Annotation Date: 2008-11-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3814426
Age: postnatal adult
Specimen Label: Table I
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309440
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422823
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH2838; Specimen C3648
Detected: false
Specimen Num: 1
Publication
First Author: Lopez AM
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.
Volume: 454
Issue: 1
Pages: 162-6
Publication
First Author: Shen ZQ
Year: 2017
Journal: Cell Rep
Title: CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma.
Volume: 21
Issue: 8
Pages: 2198-2211
Publication
First Author: Yuan Q
Year: 2013
Journal: J Lipid Res
Title: Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE.
Volume: 54
Issue: 11
Pages: 3078-84
Publication
First Author: Du H
Year: 2005
Journal: Am J Hum Genet
Title: The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy.
Volume: 77
Issue: 6
Pages: 1061-74
Publication
First Author: Wagner C
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.
Volume: 1865
Issue: 8
Pages: 158730
Publication
First Author: Bie J
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Macrophage-specific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice.
Volume: 302
Issue: 10
Pages: E1283-91
Publication
First Author: Aqul A
Year: 2011
Journal: J Neurosci
Title: Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
Volume: 31
Issue: 25
Pages: 9404-13
Publication
First Author: Fischer AW
Year: 2021
Journal: Cell Metab
Title: Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation.
Volume: 33
Issue: 3
Pages: 547-564.e7
Publication
First Author: Zhao T
Year: 2015
Journal: Oncogene
Title: Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal(-/-) mice.
Volume: 34
Issue: 15
Pages: 1938-48
Publication
First Author: Ramirez CM
Year: 2011
Journal: J Lipid Res
Title: Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.
Volume: 52
Issue: 4
Pages: 688-98
Publication
First Author: Lian X
Year: 2005
Journal: Am J Pathol
Title: Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice.
Volume: 167
Issue: 3
Pages: 813-21
Publication
First Author: Zhao T
Year: 2016
Journal: Oncotarget
Title: Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis.
Volume: 7
Issue: 2
Pages: 1529-43
Publication  
First Author: Zhao T
Year: 2022
Journal: JCI Insight
Title: Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
Volume: 7
Issue: 17
Publication
First Author: Huang SC
Year: 2014
Journal: Nat Immunol
Title: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Volume: 15
Issue: 9
Pages: 846-55
Publication
First Author: Kooistra MK
Year: 2012
Journal: Physiol Genomics
Title: Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.
Volume: 44
Issue: 1
Pages: 35-46
Publication  
First Author: Kobayashi K
Year: 2023
Journal: Life Sci Alliance
Title: Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.
Volume: 6
Issue: 10
Publication
First Author: Labialle S
Year: 2014
Journal: EMBO J
Title: The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Volume: 33
Issue: 19
Pages: 2216-30
Publication
First Author: Abdallah BM
Year: 2011
Journal: J Bone Miner Res
Title: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Volume: 26
Issue: 7
Pages: 1457-71
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: lysosomal acid lipase A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Eggert T
Year: 2001
Journal: FEBS Lett
Title: Lipolytic enzymes LipA and LipB from Bacillus subtilis differ in regulation of gene expression, biochemical properties, and three-dimensional structure.
Volume: 502
Issue: 3
Pages: 89-92
GO Term
DO Term
DO Term
DO Term
Allele
Name: lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Lipa/Lipa
Background: involves: 129P2/OlaHsd * CF-1
Zygosity: hm
Has Mutant Allele: true
Protein Domain
Type: Family
Description: Lipoic acid is an organosulphur compound that is an essential coenzyme in several multienzyme complexes, including pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and the glycine cleavage system. Many Gram-positive bacteria, such as Bacillus subtilis, require three proteins for lipoic acid cofactor biosynthesis: LipJ, LipL and LipM [, ]. LipM is a lipoate:protein ligase that transfers an octanoyl moiety from acyl-carrier protein to the GcvH protein of the glycine cleavage system. LipL, an octanoyltransferase, then transfers this moiety from GcvH to other enzyme complexes. LipA inserts the sulphur group to form the active lipoate cofactor.This entry represents the LipM component of this system.
Publication
First Author: Tzeng YL
Year: 2005
Journal: Infect Immun
Title: Translocation and surface expression of lipidated serogroup B capsular Polysaccharide in Neisseria meningitidis.
Volume: 73
Issue: 3
Pages: 1491-505
Publication
First Author: Townsend GE 2nd
Year: 2008
Journal: Mol Microbiol
Title: Identification and characterization of KpsS, a novel polysaccharide sulphotransferase in Mesorhizobium loti.
Volume: 68
Issue: 5
Pages: 1149-64
Publication
First Author: Townsend GE 2nd
Year: 2006
Journal: J Bacteriol
Title: Mesorhizobium loti produces nodPQ-dependent sulfated cell surface polysaccharides.
Volume: 188
Issue: 24
Pages: 8560-72
Publication
First Author: Martin N
Year: 2011
Journal: Mol Microbiol
Title: A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
Volume: 80
Issue: 2
Pages: 335-49
Publication
First Author: Christensen QH
Year: 2011
Journal: Mol Microbiol
Title: A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
Volume: 80
Issue: 2
Pages: 350-63
Protein Domain
Type: Family
Description: This family includes export proteins involved in capsule polysaccharide biosynthesis, such as KpsS and LipB . Capsule polysaccharide modification protein lipB/A is involved in the phospholipid modification of the capsular polysaccharide and is a strong requirement for its translocation to the cell surface. The capsule of Neisseria meningitidis serogroup B and of other meningococcal serogroups and other Gram-negative bacterial pathogens, are anchored in the outer membrane through a 1,2-diacylglycerol moiety. The lipA and lipB genes are located on the 3' end of the ctr operon. lipA and lipB do not encode proteins responsible for diacylglycerophosphatidic acid substitution of the meningococcal capsule polymer, but they are required for proper translocation and surface expression of the lipidated polymer [].KpsS is an unusual sulphate-modified form of the capsular polysaccharide in Rhizobium loti (Mesorhizobium loti). Many plants, including R. loti, enter into symbiotic relationships with bacteria that allow survival in nutrient-limiting environments. KpsS functions as a fucosyl sulphotransferase in vitro. The kpsS gene product shares no significant amino acid similarity with previously identified sulphotransferases []. Sulphated cell surface polysaccharides are required for optimum nodule formation but limit growth rate and nodule colonisation in M. loti [].
Publication
First Author: Christensen QH
Year: 2011
Journal: J Biol Chem
Title: A complex lipoate utilization pathway in Listeria monocytogenes.
Volume: 286
Issue: 36
Pages: 31447-56
Protein Domain
Type: Family
Description: Lipoic acid is an organosulphur compound that is an essential coenzyme in several multienzyme complexes, including pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and the glycine cleavage system. Many Gram-positive bacteria, such as Bacillus subtilis, require three proteins for lipoic acid cofactor biosynthesis: LipJ, LipL and LipM [, ]. LipM is a lipoate:protein ligase that transfers an octanoyl moiety from acyl-carrier protein to the GcvH protein of the glycine cleavage system. LipL, an octanoyltransferase, then transfers this moiety from GcvH to other enzyme complexes. LipA inserts the sulphur group to form the active lipoate cofactor.This entry represents the LipL component of this system. It includes Lipoyl-[GcvH]:protein N-lipoyltransferase from Listeria monocytogenes serovar 1/2a () []and Octanoyl-[GcvH]:protein N-octanoyltransferase () from Bacillus subtilis [].
Publication
First Author: Grijalva A
Year: 2016
Journal: Diabetes
Title: Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue.
Volume: 65
Issue: 4
Pages: 967-80
Publication
First Author: Li H
Year: 2005
Journal: J Neuropathol Exp Neurol
Title: Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.
Volume: 64
Issue: 4
Pages: 323-33
Publication
First Author: Holmes RS
Year: 2010
Journal: Comp Biochem Physiol Part D Genomics Proteomics
Title: Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo).
Volume: 5
Issue: 3
Pages: 217-26
Publication
First Author: Zhang H
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.
Volume: 37
Issue: 11
Pages: 2156-2160