Type |
Details |
Score |
Publication |
First Author: |
Lokmane L |
Year: |
2010 |
Journal: |
Development |
Title: |
vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. |
Volume: |
137 |
Issue: |
2 |
Pages: |
347-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paces-Fessy M |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. |
Volume: |
21 |
Issue: |
14 |
Pages: |
3143-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerber SD |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. |
Volume: |
335 |
Issue: |
1 |
Pages: |
106-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daou N |
Year: |
2013 |
Journal: |
Development |
Title: |
A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. |
Volume: |
140 |
Issue: |
24 |
Pages: |
4914-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pitera JE |
Year: |
2008 |
Journal: |
Hum Mol Genet |
Title: |
Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. |
Volume: |
17 |
Issue: |
24 |
Pages: |
3953-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Birol O |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. |
Volume: |
409 |
Issue: |
1 |
Pages: |
139-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nie X |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. |
Volume: |
352 |
Issue: |
1 |
Pages: |
141-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalousova A |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Dachshund homologues play a conserved role in islet cell development. |
Volume: |
348 |
Issue: |
2 |
Pages: |
143-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grote D |
Year: |
2006 |
Journal: |
Development |
Title: |
Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. |
Volume: |
133 |
Issue: |
1 |
Pages: |
53-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hilliard SA |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Mdm2 is required for maintenance of the nephrogenic niche. |
Volume: |
387 |
Issue: |
1 |
Pages: |
1-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muthu V |
Year: |
2019 |
Journal: |
Development |
Title: |
Genomic architecture of Shh-dependent cochlear morphogenesis. |
Volume: |
146 |
Issue: |
18 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mori AD |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. |
Volume: |
297 |
Issue: |
2 |
Pages: |
566-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkinson LJ |
Year: |
2015 |
Journal: |
Kidney Int |
Title: |
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling. |
Volume: |
87 |
Issue: |
5 |
Pages: |
975-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu WX |
Year: |
2010 |
Journal: |
Dev Dyn |
Title: |
Identification of genes controlled by LMX1B in E13.5 mouse limbs. |
Volume: |
239 |
Issue: |
8 |
Pages: |
2246-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maclean G |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. |
Volume: |
238 |
Issue: |
3 |
Pages: |
732-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoo D |
Year: |
2022 |
Journal: |
Elife |
Title: |
Little skate genome provides insights into genetic programs essential for limb-based locomotion. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Weng J |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. |
Volume: |
105 |
Issue: |
16 |
Pages: |
6081-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maga AM |
Year: |
2015 |
Journal: |
Front Physiol |
Title: |
Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. |
Volume: |
6 |
|
Pages: |
92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Racedo SE |
Year: |
2017 |
Journal: |
PLoS Genet |
Title: |
Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. |
Volume: |
13 |
Issue: |
3 |
Pages: |
e1006687 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss AC |
Year: |
2023 |
Journal: |
Development |
Title: |
Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. |
Volume: |
150 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss AC |
Year: |
2020 |
Journal: |
J Pathol |
Title: |
Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. |
Volume: |
252 |
Issue: |
3 |
Pages: |
290-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaminski MM |
Year: |
2016 |
Journal: |
Nat Cell Biol |
Title: |
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. |
Volume: |
18 |
Issue: |
12 |
Pages: |
1269-1280 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2012 |
Journal: |
Development |
Title: |
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. |
Volume: |
139 |
Issue: |
10 |
Pages: |
1863-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lanier J |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. |
Volume: |
238 |
Issue: |
12 |
Pages: |
3065-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osafune K |
Year: |
2006 |
Journal: |
Development |
Title: |
Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. |
Volume: |
133 |
Issue: |
1 |
Pages: |
151-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mugford JW |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. |
Volume: |
333 |
Issue: |
2 |
Pages: |
312-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ide S |
Year: |
2018 |
Journal: |
J Am Soc Nephrol |
Title: |
Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2795-2808 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dasgupta K |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. |
Volume: |
455 |
Issue: |
2 |
Pages: |
434-448 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaiser M |
Year: |
2021 |
Journal: |
Development |
Title: |
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. |
Volume: |
148 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Basta JM |
Year: |
2014 |
Journal: |
Development |
Title: |
Sall1 balances self-renewal and differentiation of renal progenitor cells. |
Volume: |
141 |
Issue: |
5 |
Pages: |
1047-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yates LL |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. |
Volume: |
19 |
Issue: |
23 |
Pages: |
4663-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thiagarajan RD |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. |
Volume: |
6 |
Issue: |
2 |
Pages: |
e17286 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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|
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7526429 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1667117 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:7526722 |
Age: |
embryonic day 10.5 |
|
Note: |
Coexpressed with Eya1 in the otic ectoderm. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7526429 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619713 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:7526722 |
Age: |
embryonic day 8.5 |
|
Note: |
Coexpressed with Eya1 in the otic ectoderm. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7526429 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619514 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:7526722 |
Age: |
embryonic day 9.0 |
|
Note: |
Coexpressed with Eya1 in the ventral wall. |
Specimen Label: |
6N |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. |
|
•
•
•
•
•
|
Publication |
First Author: |
Yashima T |
Year: |
2003 |
Journal: |
Acta Otolaryngol |
Title: |
Mutation of the EYA1 gene in patients with branchio-oto syndrome. |
Volume: |
123 |
Issue: |
2 |
Pages: |
279-82 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7526429 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3524722 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7526722 |
Age: |
embryonic day 14.0 |
|
Note: |
Coexpressed with Eya1 in the sensory progenitors at the site of the future organ of Corti. |
Specimen Label: |
4J/K |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7567659 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3559221 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7567674 |
Age: |
embryonic day 13.5 |
|
Note: |
Co-expression with Eya1 and Rbck1 in developing nephrons in outer region of kidney. |
Specimen Label: |
3C Sipl1 kidney |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7567660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-12-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3559221 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7567675 |
Age: |
embryonic day 13.5 |
|
Note: |
Co-expression with Eya1 and Sharpin in developing nephrons in outer region of kidney. |
Specimen Label: |
3C Rbck1 kidney |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2004 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10. |
Volume: |
5 |
Issue: |
3 |
Pages: |
295-304 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7526429 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3524721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7526721 |
Age: |
embryonic day 13.5 |
|
Note: |
Expressed in a broad group of cells in the less mature apical region throughout the thickness of the epithelium including the site of the future organ of Corti, and overlapped with Eya1 domain. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Farabaugh SM |
Year: |
2012 |
Journal: |
Oncogene |
Title: |
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. |
Volume: |
31 |
Issue: |
5 |
Pages: |
552-62 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [, ], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage []. EYA proteins (EYA1-4) are normally expressed early in development [, ]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [].EYA2 plays an important role in hypaxial muscle development together with Six1 and Dach2; in this it is functionally redundant with EYA1 []. EYA2 is a necessary co-factor for many of the metastasis promoting functions of Six1 []. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwang GH |
Year: |
2024 |
Journal: |
Cancer Res |
Title: |
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. |
Volume: |
84 |
Issue: |
6 |
Pages: |
872-886 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh N |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. |
Volume: |
109 |
Issue: |
36 |
Pages: |
14381-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu CT |
Year: |
2012 |
Journal: |
Development |
Title: |
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. |
Volume: |
139 |
Issue: |
13 |
Pages: |
2330-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson C |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis. |
Volume: |
7 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Blanc RS |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate. |
Volume: |
37 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Baxi A |
Year: |
2023 |
Journal: |
Dev Dyn |
Title: |
Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural crest patterning and bone development. |
Volume: |
252 |
Issue: |
10 |
Pages: |
1303-1315 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkerson BA |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea. |
Volume: |
9 |
Issue: |
1 |
Pages: |
9060 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jemc J |
Year: |
2007 |
Journal: |
Annu Rev Biochem |
Title: |
The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. |
Volume: |
76 |
|
Pages: |
513-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tootle TL |
Year: |
2003 |
Journal: |
Nature |
Title: |
The transcription factor Eyes absent is a protein tyrosine phosphatase. |
Volume: |
426 |
Issue: |
6964 |
Pages: |
299-302 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
450
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
502
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
614
|
Fragment?: |
true |
|
•
•
•
•
•
|