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Search results 101 to 200 out of 208 for Pgap1

0.037s
Type Details Score
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283722
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1842522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Note: Expression was not detected in the endocrine system.
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:5295949
Assay Type: RNA in situ
Annotation Date: 2011-11-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5295954
Age: embryonic day 8.5
Image: 9b
Note: Highest expression was detected in the dorsal neural folds.
Specimen Label: 9b
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759722
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4426238
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422340
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: ES2584; Specimen S982
Detected: false
Specimen Num: 1
Publication
First Author: Juriloff DM
Year: 1985
Journal: J Craniofac Genet Dev Biol
Title: Genetic and developmental studies of a new mouse mutation that produces otocephaly.
Volume: 5
Issue: 2
Pages: 121-45
Publication
First Author: Adams DJ
Year: 2004
Journal: Nat Genet
Title: Mutagenic insertion and chromosome engineering resource (MICER).
Volume: 36
Issue: 8
Pages: 867-71
Publication
First Author: Zoltewicz JS
Year: 2009
Journal: PLoS One
Title: Wnt signaling is regulated by endoplasmic reticulum retention.
Volume: 4
Issue: 7
Pages: e6191
Publication
First Author: Schwander M
Year: 2007
Journal: J Neurosci
Title: A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.
Volume: 27
Issue: 9
Pages: 2163-75
Publication
First Author: Zoltewicz JS
Year: 1999
Journal: Development
Title: oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1.
Volume: 126
Issue: 22
Pages: 5085-95
Publication
First Author: Feng S
Year: 2017
Journal: Sci Rep
Title: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.
Volume: 7
Issue: 1
Pages: 5282
Publication
First Author: McKean DM
Year: 2012
Journal: Biol Open
Title: Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly.
Volume: 1
Issue: 9
Pages: 874-83
Publication  
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
Publication
First Author: Bulfone A
Year: 2005
Journal: J Neurosci
Title: Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Volume: 25
Issue: 33
Pages: 7586-600
Publication
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
Publication      
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Murakami Y
Year: 2014
Journal: PLoS Genet
Title: Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy.
Volume: 10
Issue: 5
Pages: e1004320
Publication
First Author: Tanaka S
Year: 2004
Journal: J Biol Chem
Title: Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p.
Volume: 279
Issue: 14
Pages: 14256-63
Protein Domain
Type: Family
Description: PGAP1 (Bst1 in yeast) functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body []. Mutations of the PGAP1 gene cause mental retardation, autosomal recessive 42 (MRT42) [].
Publication
First Author: Wong KH
Year: 1984
Journal: Exp Mol Pathol
Title: Hepatic adenylate cyclase and phosphodiesterase activity during acute ethionine intoxication.
Volume: 40
Issue: 1
Pages: 122-34
Protein Domain
Type: Family
Description: The sequences found in this family are similar to PGAP1 (). This is an endoplasmic reticulum membrane protein with a catalytic serine-containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important not only for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body but also for efficient degradation of misfolded GPI-anchored proteins in the ER [, ].
Protein
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
Publication
First Author: Tashima Y
Year: 2006
Journal: Mol Biol Cell
Title: PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins.
Volume: 17
Issue: 3
Pages: 1410-20
Publication
First Author: Maeda Y
Year: 2007
Journal: Mol Biol Cell
Title: Fatty acid remodeling of GPI-anchored proteins is required for their raft association.
Volume: 18
Issue: 4
Pages: 1497-506
Protein Domain
Type: Family
Description: PGAP2, also known as FRAG1, is involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation []. Immediately after attachment of GPI to newly synthesized proteins, inositol-linked palmitate is removed by deacylase PGAP1 in the ER. The inositol-deacylation is essential for subsequent steps in fatty acid remodeling in the Golgi. PGAP3 removes an unsaturated fatty chain at sn-2 and PGAP2 reacylation of sn-2 with stearic acid follows [].
Publication
First Author: Xu J
Year: 2014
Journal: Psychiatry Res
Title: Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice.
Volume: 220
Issue: 3
Pages: 1131-7
Publication
First Author: Lohoff FW
Year: 2010
Journal: Am J Med Genet B Neuropsychiatr Genet
Title: Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.
Volume: 153B
Issue: 3
Pages: 830-6
Protein Domain
Type: Domain
Description: Metallophosphoesterase 1 (MPPE1), also known as PGAP5, acts as a phosphodiesterase removing an ethanolamine phosphate (EtN-P) from mannose 2 of the glycosylphosphatidylinositol (GPI) anchor, thus permitting efficient endoplasmic reticulum (ER) to Golgi transport of GPI proteins[]. Before GPI-anchored proteins exist the ER, two remodeling reaction, inositol deacylation by PGAP1 and removal of the second EtNP by PGAP5, occur in mammalian cells. The MPPE1 gene has been identified as a candidate susceptibility gene for Bipolar disorder [].MPPE1 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain consisting of a double β-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Publication
First Author: Fujita M
Year: 2009
Journal: Cell
Title: GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.
Volume: 139
Issue: 2
Pages: 352-65
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false