MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [, ]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [].
MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [, ]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [].
