Type |
Details |
Score |
Publication |
First Author: |
Traister A |
Year: |
2008 |
Journal: |
Biochem J |
Title: |
Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface. |
Volume: |
410 |
Issue: |
3 |
Pages: |
503-11 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
20 |
Description: |
Palmitoleoyl-protein carboxylesterase NOTUM |
Type: |
chain |
End: |
503 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Kakugawa S |
Year: |
2015 |
Journal: |
Nature |
Title: |
Notum deacylates Wnt proteins to suppress signalling activity. |
Volume: |
519 |
Issue: |
7542 |
Pages: |
187-192 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
328
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Antisense lncRNA Gene |
Type: |
antisense_lncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1.1, Genoway |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST172035, Lexicon Genetics |
Allele Type: |
Gene trapped |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 150, Debora Sinner |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST204303, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST464316, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap E206B10, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1.1, Christine Perret |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 1, The Centre for Phenogenomics |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST23790, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST324389, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST209188, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1b, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST13606A6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST10792F3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST10792F4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap IST12618C12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST14634C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notum/Notum |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notum/Notum |
Background: |
involves: 129S5/SvEvBrd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notum/Notum |
Background: |
C57BL/6NCrl-Notum/Tcp |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Vercauteren I |
Year: |
2002 |
Journal: |
Mol Plant Microbe Interact |
Title: |
An Arabidopsis thaliana pectin acetylesterase gene is upregulated in nematode feeding sites induced by root-knot and cyst nematodes. |
Volume: |
15 |
Issue: |
4 |
Pages: |
404-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Souza A |
Year: |
2014 |
Journal: |
Planta |
Title: |
Identification and functional characterization of the distinct plant pectin esterases PAE8 and PAE9 and their deletion mutants. |
Volume: |
240 |
Issue: |
5 |
Pages: |
1123-38 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family includes protein Notum from animals and pectinacetylesterase (PAE) from plants. Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins. Notum constitutes the first known extracellular protein deacylase [, ]. PAEs catalyse the deacetylation of pectin, a major compound of primary cell walls [, ]. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notum/Notum<+> |
Background: |
involves: 129S5/SvEvBrd * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notum/Notum<+> |
Background: |
C57BL/6NCrl-Notum/Tcp |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Axin2/Axin2 Notum/Notum<+> |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Axin2/Axin2<+> Notum/Notum<+> |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Seldin MM |
Year: |
2018 |
Journal: |
Cell Metab |
Title: |
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. |
Volume: |
27 |
Issue: |
5 |
Pages: |
1138-1155.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kozmik Z |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex. |
Volume: |
73 |
Issue: |
2 |
Pages: |
140-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|