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Search results 101 to 166 out of 166 for Frs3

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4835022
Age: embryonic day 11.5
Specimen Label: 1H inset
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4835022
Age: embryonic day 14.5
Specimen Label: 2D
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4835022
Age: embryonic day 18.5
Specimen Label: 2J
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:5507802
Assay Type: RNA in situ
Annotation Date: 2013-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5507870
Age: embryonic day 11.5
Image: 3I
Specimen Label: 3I
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5507802
Assay Type: RNA in situ
Annotation Date: 2013-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1707118
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:5508194
Age: embryonic day 11.0
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4835022
Age: embryonic day 14.5
Specimen Label: 1J
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4835022
Age: embryonic day 14.5
Specimen Label: 2B
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4835022
Age: embryonic day 14.5
Specimen Label: 2D
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:4835015
Assay Type: RNA in situ
Annotation Date: 2010-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2778222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4835022
Age: embryonic day 14.5
Specimen Label: 1L & 1N
Detected: true
Specimen Num: 6
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Publication
29155277 | J:258097
 
First Author: Nandi S
Year: 2018
Journal: Neuroscience
Title: Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
Volume: 369
Pages: 192-201
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Publication
19187780 | J:306394
First Author: Minegishi Y
Year: 2009
Journal: FEBS Lett
Title: Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.
Volume: 583
Issue: 4
Pages: 807-14
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Publication
17901128 | J:130043
First Author: Zhang Y
Year: 2008
Journal: Mol Endocrinol
Title: Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
Volume: 22
Issue: 1
Pages: 167-75
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Publication
15569927 | J:94724
First Author: Gotoh N
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
Volume: 101
Issue: 49
Pages: 17144-9
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Publication
26341559 | J:226497
First Author: Brewer JR
Year: 2015
Journal: Genes Dev
Title: Fgfr1 regulates development through the combinatorial use of signaling proteins.
Volume: 29
Issue: 17
Pages: 1863-74
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Pathway
R-MMU-9028731 | Activated NTRK2 signals through FRS2 and FRS3
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Publication
12688531 | -
First Author: Zhou L
Year: 2003
Journal: Mol Biol Rep
Title: Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes.
Volume: 30
Issue: 1
Pages: 15-25
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Protein Coding Gene
MGI:97381 | Ntf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80VU4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein Coding Gene
MGI:97384 | Ntrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88145 | Bdnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P21237
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
P15209
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Publication
11090629 | -
First Author: Dhalluin C
Year: 2000
Journal: Mol Cell
Title: Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.
Volume: 6
Issue: 4
Pages: 921-9
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Publication
20454865 | -
First Author: Koshiba S
Year: 2010
Journal: J Struct Funct Genomics
Title: Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.
Volume: 11
Issue: 2
Pages: 125-41
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Publication
27526776 | -
 
First Author: Sain N
Year: 2016
Journal: Sci Rep
Title: Understanding the molecular basis of substrate binding specificity of PTB domains.
Volume: 6
Pages: 31418
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Protein Domain
IPR038742 | FRS2_PTB
Type: Domain
Description: FRS2 (also called Suc1-associated neurotrophic factor (SNT)-induced tyrosine-phosphorylated target) proteins are membrane-anchored adaptor proteins. They are composed of an N-terminal myristoylation site followed by a phosphotyrosine binding (PTB) domain, which has a PH-like fold, and a C-terminal effector domain containing multiple tyrosine and serine/threonine phosphorylation site. The FRS2/SNT proteins show increased tyrosine phosphorylation by activated receptors, such as fibroblast growth factor receptor (FGFR) and TrkA, recruit SH2 domain containing proteins such as Grb2, and mediate signals from activated receptors to a variety of downstream pathways. The PTB domains of the SNT proteins directly interact with the canonical NPXpY motif of TrkA in a phosphorylation dependent manner, they directly bind to the juxtamembrane region of FGFR in a phosphorylation-independent manner [, ]. This domain can also be found in FRS3 []. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lacking tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This domain is part of the IRS-like subgroup [, ].
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Protein Coding Gene
MGI:1100860 | Frs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62245
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Protein
Q91WJ0
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
15567406 | -
First Author: Uhlik MT
Year: 2005
Journal: J Mol Biol
Title: Structural and evolutionary division of phosphotyrosine binding (PTB) domains.
Volume: 345
Issue: 1
Pages: 1-20
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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