Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Glutaredoxin domain-containing cysteine-rich protein 1 (GRXCR1) contains a region of similarity to glutaredoxin proteins and a cysteine-rich region at its C terminus. It may be involved in regulation of actin filament architecture in hair cell stereocilia []. Mutations of the GRXCR1 gene cause deafness, autosomal recessive, 25 (DFNB25) []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Odeh H |
Year: |
2010 |
Journal: |
Am J Hum Genet |
Title: |
Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. |
Volume: |
86 |
Issue: |
2 |
Pages: |
148-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schraders M |
Year: |
2010 |
Journal: |
Am J Hum Genet |
Title: |
Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment. |
Volume: |
86 |
Issue: |
2 |
Pages: |
138-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lorente-Cánovas B |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells. |
Volume: |
17 |
Issue: |
3 |
Pages: |
e0261530 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
290
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
296
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Woolley GW |
Year: |
1945 |
Journal: |
J Hered |
Title: |
Pirouetting mice. |
Volume: |
36 |
Issue: |
9 |
Pages: |
281-284 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohrman DC |
Year: |
1998 |
Journal: |
Hered Deaf News |
Title: |
Genetic, functional, and morphological analysis of pirouette, a mouse neuroepithelial deafness mutant. |
Volume: |
15 |
|
Pages: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beyer LA |
Year: |
2000 |
Journal: |
J Neurocytol |
Title: |
Hair cells in the inner ear of the pirouette and shaker 2 mutant mice. |
Volume: |
29 |
Issue: |
4 |
Pages: |
227-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Odeh H |
Year: |
2004 |
Journal: |
Audiol Neurootol |
Title: |
Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus. |
Volume: |
9 |
Issue: |
5 |
Pages: |
303-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
DEOL MS |
Year: |
1956 |
Journal: |
Proc R Soc Lond B Biol Sci |
Title: |
The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse. |
Volume: |
145 |
Issue: |
919 |
Pages: |
206-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sidman M |
Year: |
1966 |
Journal: |
Exp Neurol |
Title: |
Hearing and vision in neurological mutant mice: a method for their evaluation. |
Volume: |
16 |
Issue: |
4 |
Pages: |
377-402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karolyi IJ |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. |
Volume: |
12 |
Issue: |
21 |
Pages: |
2797-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
KOCHER W |
Year: |
1960 |
Journal: |
Z Vererbungsl |
Title: |
[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)]. |
Volume: |
91 |
|
Pages: |
114-40 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Erven A |
Year: |
2002 |
Journal: |
Eur J Neurosci |
Title: |
A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil. |
Volume: |
16 |
Issue: |
8 |
Pages: |
1433-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gagnon LH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Spontaneous Mutations to Pirouette |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gagnon LH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Molecular Analysis of the pi-4J Allele |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7435040 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-02-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7435053 |
Age: |
postnatal day 90 |
Image: |
9 |
|
Specimen Label: |
P90 +/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7435040 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-02-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7435053 |
Age: |
postnatal day 90 |
Image: |
9 |
|
Specimen Label: |
P90 -/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1858023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_05 |
|
Specimen Label: |
euxassay_013101_05 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1858023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_06 |
|
Specimen Label: |
euxassay_013101_06 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1858023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_21 |
|
Specimen Label: |
euxassay_013101_21 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1858023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_22 |
|
Specimen Label: |
euxassay_013101_22 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1858023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_23 |
|
Specimen Label: |
euxassay_013101_23 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_04 |
|
Specimen Label: |
euxassay_013101_04 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425469 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1729323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825248 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013101_06 |
|
Specimen Label: |
euxassay_013101_06 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. |
Volume: |
25 |
Issue: |
5 |
Pages: |
1268-1280.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
DICKIE MM |
Year: |
1946 |
Journal: |
J Hered |
Title: |
Linkage studies with the pirouette gene in the mouse. |
Volume: |
37 |
Issue: |
11 |
Pages: |
335-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hagiwara N |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Nonneuronal expression of the GABA(A) beta3 subunit gene is required for normal palate development in mice. |
Volume: |
254 |
Issue: |
1 |
Pages: |
93-101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lane PW |
Year: |
1967 |
Journal: |
J Hered |
Title: |
Linkage groups 3 and XVII in the mouse and the position of the light-ear locus. |
Volume: |
58 |
Issue: |
1 |
Pages: |
21-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, UK, 22-23 September 1996. Hughes DC |
Year: |
1997 |
Journal: |
Br J Audiol |
Title: |
British Society of Audiology short pMapping of the mouse alpha 9 acetylcholine receptor subunit. |
Volume: |
31 |
Issue: |
2 |
Pages: |
73-132 (84 Abstr.) |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodríguez-de la Rosa L |
Year: |
2015 |
Journal: |
Hear Res |
Title: |
Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. |
Volume: |
330 |
Issue: |
Pt A |
Pages: |
62-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bailey DW |
Year: |
1972 |
Journal: |
Mouse News Lett |
Title: |
Located histocompatibility genes. |
Volume: |
47 |
|
Pages: |
18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Potter PK |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. |
Volume: |
7 |
|
Pages: |
12444 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Avenarius MR |
Year: |
2012 |
Journal: |
PhD Thesis - University of Michigan |
Title: |
The Glutaredoxin-like Cysteine-rich Family of Genes, Grxcr1 and Grxcr2, in Stereocilia Development and Function |
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DO Term |
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Allele |
Name: |
glutaredoxin, cysteine rich 1; pirouette |
Allele Type: |
Spontaneous |
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Strain |
Attribute String: |
mutant strain, spontaneous mutation, congenic |
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Strain |
Attribute String: |
mutant stock, spontaneous mutation |
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Strain |
Attribute String: |
congenic, mutant strain, spontaneous mutation |
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Genotype |
Symbol: |
Grxcr1/Grxcr1 |
Background: |
B6.C3-Grxcr1/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Grxcr1/Grxcr1 |
Background: |
involves: C3H |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Avenarius MR |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Grxcr2 is required for stereocilia morphogenesis in the cochlea. |
Volume: |
13 |
Issue: |
8 |
Pages: |
e0201713 |
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