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Search results 801 to 900 out of 912 for Nf1

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Type Details Score
HT Experiment
E-GEOD-42603 | The data of differentially regulated exons from mouse testes - wild-type and Dazap1 mutant
Series Id: GSE42603
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
10360836 | -
First Author: Kaufmann D
Year: 1999
Journal: DNA Cell Biol
Title: EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas.
Volume: 18
Issue: 5
Pages: 345-56
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Allele
Nf1<tm1Par> | MGI:2176057
Name: neurofibromin 1; targeted mutation 1, Luis F Parada
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Nf1/Nf1<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Syn1-cre)671Jxm/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+>
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Grin1/Grin1<+> Nf1/Nf1<+>
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Trp53/Trp53<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Mpz-cre)94Imeg/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Pax3-cre)1Joe/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 H2az2/H2az2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Fabp7-cre,-lacZ)3Gtm/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten<+> Tg(Gfap-cre)77.6Mvs/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Dhh-cre)1Mejr/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * C57BL/6NTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Dhh-cre)1Mejr/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+>
Background: involves: C3HeB/FeJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
2898299 | J:48632
First Author: Muller WJ
Year: 1988
Journal: Cell
Title: Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene.
Volume: 54
Issue: 1
Pages: 105-15
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HT Experiment
E-GEOD-29343 | Neurofibromin (Nf1) is required for skeletal muscle development
Series Id: GSE29343
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:5653868 | either: (involves: 129-Nf1<tm1Fcr>) or (involves: 129S/SvEv * C57BL/6J)
Attribute String: Not specified
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Strain
MGI:5651590 | either: (involves: 129-Nf1<tm1Fcr>) or (involves: 129S6/SvEvTac * C57BL/6J)
Attribute String: mutant strain, targeted mutation
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Strain
MGI:3618485 | B6.129S6-Nf1<tm1Fcr>/Nci
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:3618484 | 129-Nf1<tm1Fcr>/Nci
Attribute String: targeted mutation, mutant strain
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Strain
MGI:2161573 | B6.129S6-Nf1<tm1Fcr>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Nf1/Nf1
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1
Background: involves: 129 * 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1
Background: involves: 129 * 129S/SvEv * C3H * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Trp53/Trp53
Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Tg(GFAP-cre)#Gtm/?
Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Tg(Cnp-EGFR)10Nrat/?
Background: involves: 129S/SvEv * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
18984150 | J:143214
First Author: Reilly KM
Year: 2008
Journal: Cell
Title: It takes a (dysfunctional) village to raise a tumor.
Volume: 135
Issue: 3
Pages: 408-10
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Publication
25517743 | J:217735
First Author: Gutmann DH
Year: 2014
Journal: Cancer Cell
Title: NF GEMMs already! The power and promise of mouse tumor models.
Volume: 26
Issue: 5
Pages: 596-9
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Publication
15257284 | J:92164
First Author: Wulf G
Year: 2004
Journal: EMBO J
Title: Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.
Volume: 23
Issue: 16
Pages: 3397-407
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Strain
MGI:5485395 | B6.129-Trp53<tm1Brd> Nf1<tm1Fcr>
Attribute String: mutant strain, targeted mutation, congenic
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Genotype
Genotype
Symbol: Nf1/Nf1
Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hprt1/Hprt1<+> Nf1/Nf1
Background: involves: 129S/SvEv * 129S/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Hprt1/Hprt1<+> Nf1/Nf1
Background: involves: 129S/SvEv * 129S/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Pax3/Pax3<+>
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Tsc1/Tsc1 Tg(GFAP-cre)#Gtm/?
Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Trp53/Trp53<+>
Background: B6.129-Trp53 Nf1
Zygosity: cx
Has Mutant Allele: true
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Publication
1916815 | J:11478
First Author: Xu WM
Year: 1991
Journal: Genomics
Title: The gene for von Recklinghausen neurofibromatosis (NF1) maps to the pericentromeric region of chromosome 17 in Chinese families.
Volume: 10
Issue: 4
Pages: 1090-2
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Publication
10432316 | -
 
First Author: Osada S
Year: 1999
Journal: Biochem J
Title: Expression, DNA-binding specificity and transcriptional regulation of nuclear factor 1 family proteins from rat.
Volume: 342 ( Pt 1)
Pages: 189-98
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Publication
12590132 | -
First Author: Fukuda A
Year: 2003
Journal: J Biol Chem
Title: Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH.
Volume: 278
Issue: 17
Pages: 14827-31
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Protein Domain
IPR009044 | ssDNA-bd_transcriptional_reg
Type: Homologous_superfamily
Description: This superfamily represents a ssDNA-binding transcriptional regulator domain consisting of a helix-swapped dimer of beta(4)-alpha motifs. This domain is found as a C-terminal domain in the transcriptional co-activator PC4 (also known as P15; where it is a dimer of two separate motifs), and in the plant transcriptional regulator PBF-2 (where it is a single chain domain formed by a tandem repeat of two motifs).Transcriptional regulators play a critical role in controlling the level of transcription from specific genes in response to different stimuli. Members of this family of transcriptional regulators, which preferentially bind single-stranded DNA, include PBF-2 from plants, the mammalian nuclear factor 1-X (NF1-X), and positive cofactor 4 (PC4). These proteins are structurally similar, consisting of a helix-swapped dimer of beta(4)-alpha motifs.The plant defence transcription factor PBF-2 is comprised of four p24 subunits that interact through a helix-loop-helix motif to produce a central pore []. PBF-2 functions as part of the plant's defence system in response to the detection of a pathogen. Upon stimulation, PBF-2 induces several signal transduction pathways leading to changes in the expression of defence genes, including the pathogenesis-related (PR) genes.NF1-X is one of several NF1 proteins that function as transcription factors. NF1-X consists of two functionally distinct domains: a conserved N-terminal DNA-binding domain and a C-terminal transcriptional regulatory domain. NF1-X binds to the promoter for the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase gene [].PC4 (or P15) possess the ability to co-activate and suppress transcription via its DNA-binding activity. PC4 has been shown to stimulate transcription in vitrowith diverse activators, including VP16, thyroid hormone receptor, BRCA-1, often involving TFIIA. PC4 and TFIIA are thought to facilitate the assembly of the pre-initiation complex. The repressive activity of PC4 can be alleviated by the transcription factor TFIIH, which protects promoters from PC4 repression []. PC4 consists of two domains: an N-terminal regulatory domain and a C-terminal cryptic DNA-binding domain. The protein acts as a dimer with two ssDNA binding channels running in opposite directions to each other [].
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Publication
10959417 | J:82305
 
First Author: Kane R
Year: 2000
Journal: Adv Exp Med Biol
Title: Transcription factor NF 1 expression in involuting mammary gland.
Volume: 480
Pages: 117-22
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Publication
16869751 | J:116750
 
First Author: Parada LF
Year: 2005
Journal: Cold Spring Harb Symp Quant Biol
Title: Modeling neurofibromatosis type 1 tumors in the mouse for therapeutic intervention.
Volume: 70
Pages: 173-6
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Publication
23424002 | J:316230
First Author: Pong WW
Year: 2013
Journal: Ann Neurol
Title: Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation.
Volume: 73
Issue: 2
Pages: 303-8
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Publication
25877329 | J:223339
First Author: Ratner N
Year: 2015
Journal: Nat Rev Cancer
Title: A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor.
Volume: 15
Issue: 5
Pages: 290-301
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nf1/Nf1 Tg(Tek-cre)1Ywa/?
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1 Tg(Tek-cre)1Ywa/?
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr<+> Nf1/Nf1<+> Trp53/Trp53<+>
Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ
Zygosity: cx
Has Mutant Allele: true
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Publication
9360603 | -
First Author: Brandsen J
Year: 1997
Journal: Nat Struct Biol
Title: C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
Volume: 4
Issue: 11
Pages: 900-3
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Publication
12080340 | -
First Author: Desveaux D
Year: 2002
Journal: Nat Struct Biol
Title: A new family of plant transcription factors displays a novel ssDNA-binding surface.
Volume: 9
Issue: 7
Pages: 512-7
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Publication
15767669 | J:97580
First Author: Chong JA
Year: 2005
Journal: Mol Cell Biol
Title: TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP.
Volume: 25
Issue: 7
Pages: 2632-43
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Publication
7890167 | J:23977
First Author: Raval P
Year: 1995
Journal: Gene
Title: Characterization of the 5' flanking region and gene encoding the mouse interferon-gamma receptor.
Volume: 154
Issue: 2
Pages: 219-23
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Publication
19515240 | J:151415
 
First Author: Pitulescu ME
Year: 2009
Journal: BMC Biochem
Title: TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.
Volume: 10
Pages: 16
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Publication
25117714 | J:214594
First Author: Ozawa T
Year: 2014
Journal: Cancer Cell
Title: Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma.
Volume: 26
Issue: 2
Pages: 288-300
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Publication
25822087 | J:231792
First Author: Zhao Z
Year: 2015
Journal: Nat Genet
Title: Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Volume: 47
Issue: 5
Pages: 539-43
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Publication
1505963 | J:1707
First Author: Legius E
Year: 1992
Journal: Genomics
Title: NF1-related locus on chromosome 15.
Volume: 13
Issue: 4
Pages: 1316-8
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Publication
17297459 | J:125503
First Author: Le LQ
Year: 2007
Journal: Oncogene
Title: Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.
Volume: 26
Issue: 32
Pages: 4609-16
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Publication
21305617 | J:172839
First Author: Hambardzumyan D
Year: 2011
Journal: Glia
Title: Genetic modeling of gliomas in mice: new tools to tackle old problems.
Volume: 59
Issue: 8
Pages: 1155-68
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Publication
23055477 | J:190909
First Author: Gutmann DH
Year: 2012
Journal: J Neurosci
Title: Neurofibromatosis type 1: modeling CNS dysfunction.
Volume: 32
Issue: 41
Pages: 14087-93
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Publication
22898602 | J:191819
First Author: Ward AF
Year: 2012
Journal: Blood
Title: Targeting oncogenic Ras signaling in hematologic malignancies.
Volume: 120
Issue: 17
Pages: 3397-406
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Publication
26904939 | J:270438
First Author: Wu J
Year: 2016
Journal: Cell Rep
Title: Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.
Volume: 14
Issue: 8
Pages: 1979-90
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Publication
32461556 | J:292348
First Author: Lõhmussaar K
Year: 2020
Journal: Nat Commun
Title: Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Volume: 11
Issue: 1
Pages: 2660
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Publication
34428430 | J:314108
First Author: Jecrois ES
Year: 2021
Journal: Dev Cell
Title: Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.
Volume: 56
Issue: 20
Pages: 2871-2885.e6
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Publication
35066574 | J:321223
First Author: Mo J
Year: 2022
Journal: Oncogene
Title: Neurofibromin and suppression of tumorigenesis: beyond the GAP.
Volume: 41
Issue: 9
Pages: 1235-1251
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Publication
38458648 | J:346085
 
First Author: Perrino MR
Year: 2024
Journal: Life Sci Alliance
Title: C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.
Volume: 7
Issue: 5
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Strain
MGI:5787928 | B6.Cg-Tg(Mx1-cre)1Cgn Nf1<tm1Fcr> Pten<tm1Hwu>
Attribute String: congenic, mutant strain, transgenic, targeted mutation
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Genotype
Genotype
Symbol: Nf1/Nf1 Trp53/Trp53 Tg(GFAP-cre)25Mes/?
Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Pten/Pten Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1 Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kitl/Kitl Nf1/Nf1
Background: involves: 129 * 129S/SvEv * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nf1/Nf1 Prss56/Prss56<+>
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Protein
P11031
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
7935463 | J:47441
First Author: Kikuchi A
Year: 1994
Journal: Mol Cell Biol
Title: ralGDS family members interact with the effector loop of ras p21.
Volume: 14
Issue: 11
Pages: 7483-91
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Publication
11689004 | J:72589
First Author: Scheepers A
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose.
Volume: 288
Issue: 4
Pages: 969-74
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Publication
35986378 | J:337179
First Author: Anastasaki C
Year: 2022
Journal: Acta Neuropathol Commun
Title: Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling.
Volume: 10
Issue: 1
Pages: 120
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Publication
29760048 | J:264284
First Author: Untch BR
Year: 2018
Journal: Cancer Res
Title: Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers.
Volume: 78
Issue: 16
Pages: 4642-4657
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Publication
28584132 | J:244142
First Author: Montero-Conde C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.
Volume: 114
Issue: 25
Pages: E4951-E4960
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Publication
28455524 | J:274550
First Author: Schreiber J
Year: 2017
Journal: Sci Rep
Title: Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models.
Volume: 7
Issue: 1
Pages: 1256
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Publication
33331896 | J:338790
First Author: Cui Y
Year: 2021
Journal: Hum Mol Genet
Title: Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
Volume: 29
Issue: 23
Pages: 3793-3806
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Publication
37712888 | J:344359
First Author: Wilson AF
Year: 2023
Journal: Hum Mol Genet
Title: A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells.
Volume: 32
Issue: 24
Pages: 3342-3352
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Publication
12955085 | J:85531
First Author: Johansson EM
Year: 2003
Journal: Oncogene
Title: The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy.
Volume: 22
Issue: 38
Pages: 6061-70
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Publication
10958940 | J:66628
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