Type |
Details |
Score |
Publication |
First Author: |
Zhang J |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. |
Volume: |
6 |
|
Pages: |
35986 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jensen P |
Year: |
2004 |
Journal: |
Brain Res Mol Brain Res |
Title: |
A neurogenomics approach to gene expression analysis in the developing brain. |
Volume: |
132 |
Issue: |
2 |
Pages: |
116-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
176
|
Fragment?: |
true |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
371 |
Description: |
Phosphoserine; by WNK1 and WNK4 |
Type: |
modified residue |
End: |
371 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2377
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
788
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2635
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2128
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2626
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2195
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
85
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
200
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
433
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
281
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
67
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
407
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
252
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
238
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Subramanya AR |
Year: |
2006 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. |
Volume: |
290 |
Issue: |
3 |
Pages: |
F619-24 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. |
|
•
•
•
•
•
|
Publication |
First Author: |
Delaloy C |
Year: |
2008 |
Journal: |
Hypertension |
Title: |
Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues. |
Volume: |
52 |
Issue: |
6 |
Pages: |
1149-54 |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chou-Long Huang |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Zeng G |
Year: |
2005 |
Journal: |
Gene |
Title: |
Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter. |
Volume: |
344 |
|
Pages: |
233-9 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
kelch-like 3; targeted mutation 1.1, Eisei Sohara |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Publication |
First Author: |
Lafreniere RG |
Year: |
2004 |
Journal: |
Am J Hum Genet |
Title: |
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates. |
Volume: |
74 |
Issue: |
5 |
Pages: |
1064-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Susa K |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. |
Volume: |
491 |
Issue: |
3 |
Pages: |
727-732 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Klhl3/Klhl3<+> |
Background: |
involves: C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Klhl3/Klhl3 |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki E |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. |
Volume: |
37 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kdr/Kdr<+> Wnk1/Wnk1 |
Background: |
involves: 129S1/Sv * 129S5/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2013 |
Journal: |
Gastroenterology |
Title: |
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. |
Volume: |
145 |
Issue: |
1 |
Pages: |
232-41 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wnk1/Wnk1 Tg(Tek-cre)12Flv/? |
Background: |
involves: 129S5/SvEvBrd * C3H * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wnk1/Wnk1 Edil3/Edil3<+> |
Background: |
involves: 129S5/SvEvBrd * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyd-Shiwarski CR |
Year: |
2022 |
Journal: |
Cell |
Title: |
WNK kinases sense molecular crowding and rescue cell volume via phase separation. |
Volume: |
185 |
Issue: |
24 |
Pages: |
4488-4506.e20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang SS |
Year: |
2007 |
Journal: |
Cell Metab |
Title: |
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. |
Volume: |
5 |
Issue: |
5 |
Pages: |
331-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiga M |
Year: |
2008 |
Journal: |
Kidney Int |
Title: |
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. |
Volume: |
74 |
Issue: |
11 |
Pages: |
1403-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Richards J |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. |
Volume: |
289 |
Issue: |
17 |
Pages: |
11791-806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson FH |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. |
Volume: |
100 |
Issue: |
2 |
Pages: |
680-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang CL |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. |
Volume: |
117 |
Issue: |
11 |
Pages: |
3403-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Al-Qusairi L |
Year: |
2016 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC. |
Volume: |
311 |
Issue: |
2 |
Pages: |
F330-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oi K |
Year: |
2012 |
Journal: |
Biol Open |
Title: |
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. |
Volume: |
1 |
Issue: |
2 |
Pages: |
120-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi D |
Year: |
2014 |
Journal: |
Biosci Rep |
Title: |
WNK4 is the major WNK positively regulating NCC in the mouse kidney. |
Volume: |
34 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen JC |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
WNK4 kinase is a physiological intracellular chloride sensor. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Al-Qusairi L |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. |
Volume: |
28 |
Issue: |
8 |
Pages: |
2431-2442 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CM |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain. |
Volume: |
33 |
Issue: |
1 |
Pages: |
1051-1061 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen B |
Year: |
2023 |
Journal: |
Neurobiol Dis |
Title: |
Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic stroke. |
Volume: |
176 |
|
Pages: |
105936 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rinehart J |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. |
Volume: |
102 |
Issue: |
46 |
Pages: |
16777-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou B |
Year: |
2012 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway. |
Volume: |
302 |
Issue: |
5 |
Pages: |
F533-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. |
Volume: |
275 |
Issue: |
22 |
Pages: |
16795-801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hengl T |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
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Molecular components of signal amplification in olfactory sensory cilia. |
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107 |
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13 |
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6052-7 |
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First Author: |
Fulford L |
Year: |
2016 |
Journal: |
Sci Signal |
Title: |
The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5. |
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9 |
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First Author: |
Abdel Khalek W |
Year: |
2019 |
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J Am Soc Nephrol |
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Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects. |
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30 |
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5 |
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Large MJ |
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2014 |
Journal: |
PLoS Genet |
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The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. |
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10 |
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6 |
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Year: |
2021 |
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Cells |
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6 |
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2013 |
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Am J Physiol Renal Physiol |
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Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. |
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2004 |
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DNA Res |
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Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
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11 |
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3 |
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Villén J |
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2007 |
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Proc Natl Acad Sci U S A |
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Large-scale phosphorylation analysis of mouse liver. |
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104 |
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2004 |
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Genome Res |
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
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Cell |
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A tissue-specific atlas of mouse protein phosphorylation and expression. |
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2009 |
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PLoS Biol |
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7 |
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