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Search results 1 to 100 out of 273 for Abcc9

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: ATP-binding cassette subfamily C member 9 (ABCC9, also known as the sulphonylurea receptor SUR2) is an atypical member of the ABC transporter family. Although it has the requisite domains to function as a transporter, it is a regulator of a potassium channel to which it is directly coupled in a hetero-octameric complex []. Mutations in ABCC9 cause Cantu syndrome (CS), a distinct multiorgan disease, potentially via enhanced KATP channel activity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Fahrenbach JP
Year: 2014
Journal: FASEB J
Title: Abcc9 is required for the transition to oxidative metabolism in the newborn heart.
Volume: 28
Issue: 7
Pages: 2804-15
Publication
First Author: Cooper PE
Year: 2014
Journal: Hum Mutat
Title: CantĂș syndrome resulting from activating mutation in the KCNJ8 gene.
Volume: 35
Issue: 7
Pages: 809-13
Publication
First Author: Fotinou C
Year: 2013
Journal: FEBS J
Title: Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.
Volume: 280
Issue: 4
Pages: 1051-63
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1546  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1533  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
Publication
First Author: Sudhir R
Year: 2020
Journal: Pflugers Arch
Title: Improved adaptation to physical stress in mice overexpressing SUR2A is associated with changes in the pattern of Q-T interval.
Volume: 472
Issue: 6
Pages: 683-691
Publication
First Author: Sukhodub A
Year: 2010
Journal: Pharmacol Res
Title: Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A.
Volume: 61
Issue: 6
Pages: 564-70
Publication
First Author: Sukhodub A
Year: 2011
Journal: J Cell Mol Med
Title: Nicotinamide-rich diet improves physical endurance by up-regulating SUR2A in the heart.
Volume: 15
Issue: 8
Pages: 1703-12
Publication
First Author: Smeland MF
Year: 2019
Journal: Nat Commun
Title: ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9.
Volume: 10
Issue: 1
Pages: 4457
Publication
First Author: McClenaghan C
Year: 2020
Journal: J Clin Invest
Title: Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
Volume: 130
Issue: 3
Pages: 1116-1121
Publication  
First Author: Scala R
Year: 2021
Journal: Cells
Title: Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome.
Volume: 10
Issue: 7
Publication      
First Author: York NW
Year: 2020
Journal: JCI Insight
Title: Kir6.1- and SUR2-dependent KATP over-activity disrupts intestinal motility in murine models of Cantu Syndrome.
Publication  
First Author: Zhang H
Year: 2021
Journal: JCI Insight
Title: Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.
Volume: 6
Issue: 5
Publication
First Author: Ando K
Year: 2022
Journal: Dev Cell
Title: KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling.
Volume: 57
Issue: 11
Pages: 1383-1399.e7
Publication
First Author: Liu Z
Year: 2014
Journal: J Biol Chem
Title: Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.
Volume: 289
Issue: 43
Pages: 29801-16
Publication  
First Author: Liu TY
Year: 2017
Journal: Open Biol
Title: Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Volume: 7
Issue: 1
Publication
First Author: Russell NX
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.
Volume: 325
Issue: 6
Pages: L788-L802
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ye B
Year: 2009
Journal: Circ Res
Title: Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing.
Volume: 105
Issue: 11
Pages: 1083-93
Publication
First Author: Chutkow WA
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle.
Volume: 98
Issue: 20
Pages: 11760-4
Publication
First Author: Stoller D
Year: 2007
Journal: J Mol Cell Cardiol
Title: Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress.
Volume: 43
Issue: 4
Pages: 445-54
Publication
First Author: Aggarwal NT
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice.
Volume: 299
Issue: 6
Pages: H1884-90
Publication
First Author: Kakkar R
Year: 2006
Journal: Circ Res
Title: Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process.
Volume: 98
Issue: 5
Pages: 682-9
Publication
First Author: Stoller D
Year: 2009
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice.
Volume: 297
Issue: 4
Pages: R1144-53
Publication
First Author: Chutkow WA
Year: 2002
Journal: J Clin Invest
Title: Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels.
Volume: 110
Issue: 2
Pages: 203-8
Publication
First Author: Adebiyi A
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.
Volume: 301
Issue: 4
Pages: H1360-8
Publication
First Author: Du Q
Year: 2010
Journal: Biochim Biophys Acta
Title: Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the K(ATP) channel activity.
Volume: 1803
Issue: 3
Pages: 405-15
Publication
First Author: Liang GH
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.
Volume: 300
Issue: 6
Pages: H2088-95
Publication
First Author: Chutkow WA
Year: 1999
Journal: J Biol Chem
Title: Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel.
Volume: 274
Issue: 19
Pages: 13656-65
Publication
First Author: Mohammed Abdul KS
Year: 2014
Journal: Biochim Biophys Acta
Title: Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen.
Volume: 1843
Issue: 11
Pages: 2424-31
GXD Expression      
Probe: MGI:3707809
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733125
Stage: TS25
Assay Id: MGI:3708131
Age: embryonic day 17.5
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3707809
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733127
Stage: TS27
Assay Id: MGI:3708131
Age: postnatal day 1
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707809
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Male
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:3708131
Age: postnatal week 5-8
Specimen Label: Adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: -/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: -/-
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6294979
Age: embryonic day 11.5
Specimen Label: -/-
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult brain
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult heart
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult lung
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult skeletal muscle
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult liver
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult spleen
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult kidney
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185824
Stage: TS24
Assay Id: MGI:6294990
Age: embryonic day 16.5
Specimen Label: E16.5 head
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672824
Stage: TS24
Assay Id: MGI:6294990
Age: embryonic day 16.5
Specimen Label: E16.5 lung
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6294990
Age: embryonic day 16.5
Specimen Label: E16.5 liver
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:6294990
Age: embryonic day 16.5
Specimen Label: E16.5 heart
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult intestine
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult uterus
Detected: false
Specimen Num: 13
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult aorta
Detected: false
Specimen Num: 14
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult bladder
Detected: false
Specimen Num: 15
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:6294990
Age: postnatal adult
Specimen Label: Adult stomach
Detected: false
Specimen Num: 16
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: Control
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: Control
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: NbNbl-NK
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: NbNbl-NK
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6294973
Assay Type: RT-PCR
Annotation Date: 2019-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:6295928
Age: embryonic day 14.5
Specimen Label: NbNbl-NK
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6726521
Assay Type: RT-PCR
Annotation Date: 2021-07-28
Strength: Present
Sex: Male
Emaps: EMAPS:3537527
Stage: TS27
Assay Id: MGI:6726530
Age: postnatal day 2
Image: 1
Specimen Label: PN2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6726521
Assay Type: RT-PCR
Annotation Date: 2021-07-28
Strength: Present
Sex: Male
Emaps: EMAPS:3537528
Stage: TS28
Assay Id: MGI:6726530
Age: postnatal day 28
Image: 1
Specimen Label: PN28
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7281366
Assay Type: RT-PCR
Annotation Date: 2022-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:7281378
Age: embryonic day 13.5
Image: 2
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7281366
Assay Type: RT-PCR
Annotation Date: 2022-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:7281378
Age: embryonic day 13.5
Image: 2
Specimen Label: Mutant
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7486115
Assay Type: RT-PCR
Annotation Date: 2023-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7486117
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/+>
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7486115
Assay Type: RT-PCR
Annotation Date: 2023-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7486117
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/->
Detected: true
Specimen Num: 2