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Search results 101 to 190 out of 190 for Cap1

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0.026s

Categories

Hits by Pathway

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Hits by Category

Type Details Score
GXD Expression
GXD Expression
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Note: Expression was region specific and scattered.
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945015
Age: embryonic day 11.5
Image: g00460 E11.5
Specimen Label: g00460 E11.5
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945015
Age: embryonic day 15.5
Image: g00460 E15.5
Specimen Label: g00460 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Note: Expression was region specific and scattered.
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Note: Expression was region specific and scattered.
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945015
Age: embryonic day 11.5
Image: g00460 E11.5
Specimen Label: g00460 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945015
Age: embryonic day 11.5
Image: g00460 E11.5
Specimen Label: g00460 E11.5
Detected: true
Specimen Num: 1
•
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945015
Age: embryonic day 15.5
Image: g00460 E15.5
Specimen Label: g00460 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
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•
GXD Expression
GXD Expression
   
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Specimen Label: g00460 Adult
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945015
Age: embryonic day 15.5
Image: g00460 E15.5
Specimen Label: g00460 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945015
Age: embryonic day 15.5
Image: g00460 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00460 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 7
Image: g00460 P7
Specimen Label: g00460 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882618
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945015
Age: postnatal day 42
Image: g00460 Adult
Specimen Label: g00460 Adult
Detected: true
Specimen Num: 4
•
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Publication
23439681 | J:197458
First Author: Ingerman E
Year: 2013
Journal: J Cell Biol
Title: Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly.
Volume: 200
Issue: 5
Pages: 619-33
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Publication
18524897 | J:137123
First Author: Iwasato T
Year: 2008
Journal: J Neurosci
Title: Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
Volume: 28
Issue: 23
Pages: 5931-43
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Publication
14630798 | J:152664
First Author: Coppinger JA
Year: 2004
Journal: Blood
Title: Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.
Volume: 103
Issue: 6
Pages: 2096-104
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Publication
25138159 | J:217771
First Author: Crisante G
Year: 2014
Journal: FASEB J
Title: The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
Volume: 28
Issue: 11
Pages: 4792-805
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Publication
6457647 | J:154091
First Author: Gogstad GO
Year: 1981
Journal: Biochim Biophys Acta
Title: Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.
Volume: 670
Issue: 2
Pages: 150-62
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Publication
17021036 | J:114098
First Author: Armentano M
Year: 2006
Journal: Development
Title: COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.
Volume: 133
Issue: 21
Pages: 4151-62
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Publication
22174793 | J:182258
First Author: Taher L
Year: 2011
Journal: PLoS One
Title: Global gene expression analysis of murine limb development.
Volume: 6
Issue: 12
Pages: e28358
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein
A0A3Q4L303
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
A0A3Q4EIE2
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
G3UZ59
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Protein
A0A3Q4EH87
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
A0A3Q4EGE1
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
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Protein
A0A3Q4EBV9
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: true
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Protein
A0A3Q4EHZ1
Organism: Mus musculus/domesticus
Length: 844  
Fragment?: true
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Publication
36264429 | J:347325
First Author: Heinze A
Year: 2022
Journal: Cell Mol Life Sci
Title: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology.
Volume: 79
Issue: 11
Pages: 558
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Publication
20713356 | -
First Author: Bélanger F
Year: 2010
Journal: J Biol Chem
Title: Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase.
Volume: 285
Issue: 43
Pages: 33037-44
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CL Term
CL:4028002 | alveolar capillary type 1 endothelial cell
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Protein
Q9ESD1
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Publication
17635992 | -
First Author: Deeks MJ
Year: 2007
Journal: J Cell Sci
Title: Arabidopsis CAP1 - a key regulator of actin organisation and development.
Volume: 120
Issue: Pt 15
Pages: 2609-18
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Protein
Q9DBC3
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Publication
23706023 | -
First Author: Patterson MJ
Year: 2013
Journal: Antioxid Redox Signal
Title: Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.
Volume: 19
Issue: 18
Pages: 2244-60
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Protein Coding Gene
MGI:1923810 | Prss8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18533109 | -
First Author: Haline-Vaz T
Year: 2008
Journal: Biochem Biophys Res Commun
Title: The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.
Volume: 372
Issue: 4
Pages: 719-24
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Protein Domain
IPR030376 | Cap_mRNA_MeTrfase_1
Type: Family
Description: Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 is a S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs []. It methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA to produce m7GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. It may be involved in the interferon response pathway []. This group also includes , which is thought to be inactive as it lacks the conserved Lys active site in position 367.
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Protein Domain
IPR025816 | RrmJ-type_MeTrfase
Type: Domain
Description: This domain is found in cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1, which is a S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs []. It methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA to produce m7GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. It may be involved in the interferon response pathway []. This group also includes , which is thought to be inactive as it lacks the conserved Lys active site in position 367.
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Publication
37436893 | J:338205
First Author: Dohnalkova M
Year: 2023
Journal: Cell Rep
Title: Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Volume: 42
Issue: 7
Pages: 112786
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Publication
9792810 | J:50496
First Author: Wagenfeld A
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization.
Volume: 251
Issue: 2
Pages: 545-9
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Publication
22945801 | J:226742
First Author: Peche VS
Year: 2013
Journal: Cell Mol Life Sci
Title: Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.
Volume: 70
Issue: 3
Pages: 527-43
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Publication
25464902 | J:226868
First Author: Kosmas K
Year: 2015
Journal: Eur J Cell Biol
Title: CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds.
Volume: 94
Issue: 1
Pages: 32-45
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Publication
20043279 | J:232314
First Author: Planès C
Year: 2010
Journal: EMBO Mol Med
Title: ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.
Volume: 2
Issue: 1
Pages: 26-37
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Publication
25157135 | J:216399
First Author: Gong Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation.
Volume: 111
Issue: 36
Pages: E3766-74
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Publication
11604420 | J:131211
First Author: Palmgren S
Year: 2001
Journal: J Cell Biol
Title: Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin.
Volume: 155
Issue: 2
Pages: 251-60
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Publication
21637813 | -
First Author: Decroly E
Year: 2011
Journal: PLoS Pathog
Title: Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.
Volume: 7
Issue: 5
Pages: e1002059
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Publication
27170751 | -
First Author: Zeng C
Year: 2016
Journal: J Virol
Title: Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.
Volume: 90
Issue: 15
Pages: 6675-6685
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Publication
21931546 | -
First Author: Nga PT
Year: 2011
Journal: PLoS Pathog
Title: Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes.
Volume: 7
Issue: 9
Pages: e1002215
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Publication
26041874 | -
First Author: Lehmann KC
Year: 2015
Journal: J Gen Virol
Title: Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.
Volume: 96
Issue: 9
Pages: 2643-2655
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Publication
32709886 | -
First Author: Viswanathan T
Year: 2020
Journal: Nat Commun
Title: Structural basis of RNA cap modification by SARS-CoV-2.
Volume: 11
Issue: 1
Pages: 3718
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Publication
2022266 | -
First Author: Katz E
Year: 1991
Journal: Fertil Steril
Title: Increased circulating levels of bromocriptine after vaginal compared with oral administration.
Volume: 55
Issue: 5
Pages: 882-4
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Protein Domain
IPR046438 | NIV_2_O_MTASE
Type: Domain
Description: Positive-stranded RNA (RNA) viruses that belong to the order Nidovirales infect a wide range of vertebrates (families Arteriviridae and Coronaviridae) or invertebrates (Mesoniviridae and Roniviridae). Examples of nidoviruses with high economic and societal impact are the arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) and the zoonotic coronaviruses (CoVs) causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and Covid-19 (SARS-CoV-2) in humans.The 3'-terminal region of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (NSP) 16 in CoV and implicated in methylation of the 5' cap structure of nidoviral mRNAs. Assembly of a cap1 structure at the 5' end of viral mRNA assists in translation and evading host defense. The cap structure consists of a 7-methylguanosine (m7G) linked to the first nucleotide of the RNA transcript through a 5'-5' triphosphate bridge. The CoV NSP16 methyltransferase forms an obligatory complex with NSP10 to efficiently convert client mRNA species from the cap-0 ((me7)G(0)pppA(1)) to the cap-1 form ((me7)G(0)pppA(1m)) by methylating the ribose 2'-O of the first nucleotide of the nascent mRNA using S-adenosyl methionine (SAM) as the methyl donor [, , , ].The nidovirus 2'-O-MTase domain exhibits the characteristic fold of the class I MTase family, comprising a β-sheet flanked by α-helices and loops. The nidovirus 2'-O-MTase domain harbors a catalytic K-D-K-E tetrad that is conserved among 2'-O-MTases [, , ].
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Publication
36356648 | J:331719
 
First Author: Yang HM
Year: 2023
Journal: Metabolism
Title: Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.
Volume: 138
Pages: 155343
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Publication
27126641 | J:242426
First Author: Li Q
Year: 2016
Journal: Mamm Genome
Title: Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.
Volume: 27
Issue: 5-6
Pages: 179-90
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Publication
27712628 | -
 
First Author: Snijder EJ
Year: 2016
Journal: Adv Virus Res
Title: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing.
Volume: 96
Pages: 59-126
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